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Wednesday, May 23, 2018

Sativex Can Improve Driving Ability of MS Patients, Study Says

May 22, 2018

Sativex, a cannabis-based anti-spasticity medicine commercialized as oromucosal spray by GW Pharmaceuticals, improves the driving ability of patients with multiple sclerosis (MS), according to researchers.

Sativex and driving




















Driving is an important task to help MS patients maintain the activities of daily living, including their independence, social interactions and access to work, healthcare, family and shopping.
However, MS is associated with physical, sensory and cognitive disabilities, like muscle spasticity or visual and auditory impairment, that may affect the daily living functions of patients.
Some MS treatments also are known to negatively affect the driving ability of patients. Disease-modifying drugs (DMDs), corticosteroids, and other medicines used to manage symptoms like depression, anxiety, pain and muscle spasticity, affect patients’ driving performance, including wakefulness, coordination, reaction times, and concentration.
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Tuesday, May 15, 2018

#CMSC2018 – Julie Roberts, Country Music Singer and MS Advocate, Performing at CMSC Meeting

Julie Roberts, a country music singer and multiple sclerosis (MS) patient advocate, will perform at the upcoming Consortium of Multiple Sclerosis Centers (CMSC)’s annual meeting, the association announced.
Additionally, Julie will be presenting at the MS Views and News educational program on May 29th at the Nashville Marriott Airport, as showing here. to attend this event, RSVP here.   
Roberts, diagnosed with MS while making her second recording in 2005, will also attend #CMSC sessions to learn more about potential and current treatments, and ongoing research in the disease. The conference runs from May 30 to June 2 in Nashville.
She is set to perform at the meeting’s opening John F. Kurtzke Memorial Lecture and Luncheon on Wednesday, and again at its awards reception on Friday, June 1.
Her first single, “Break Down Here,” was a Billboard Top 20 Hot Country Song and she has sold millions of albums.
Roberts says she met her diagnosis with years of denial, refusing to pursue any treatment.
“I thought if I ignored my MS it would go away,” she said in a press release. Then another disaster struck.
Record-shattering rainfall flooded Nashville in early May 2010, inundating the Roberts family home and killing 26 people across Tennessee and neighboring Kentucky. Roberts and her family were rescued by boat, after frightening hours that led to an awakening.
“The flood rescue made me realize that I needed to manage my MS, adopt a healthy and positive lifestyle, and show others that the disease does not define who you are or stop you from pursing your dreams,” she said.
She now encourages patients to find a neurologist and healthcare team they trust and feel comfortable with to ensure the care they need.
“Julie Roberts is living proof of the mission of the CMSC and its Annual Meeting – to present MS healthcare teams with the latest information and tools to provide optimum care to those living with MS,” said June Halper, chief executive officer of CMSC. “We are excited to have Julie at our conference to entertain and share her MS journey with our attendees.”
In Roberts’ latest album, “I Think You Know,” produced by Shooter Jennings,  she sings about love, loss, roots, and redemption. She also has a biography,  “Beauty in the Breakdown, Choosing to Overcome,”  set for release in September.
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Doctor Discussion Guide: Newly Diagnosed with MS

Learning you have multiple sclerosis can be alarming and frightening. Here are some questions to ask your doctor about your new diagnosis to help you…

Receiving a multiple sclerosis (MS) diagnosis can leave you feeling overwhelmed and scared. But it’s important to remember that you’re not alone. The Multiple Sclerosis Foundation estimates that there are more than 2.5 million people living with MS around the world.
It’s normal to have a lot of questions about your new diagnosis. Getting your questions answered and learning about your condition can help you feel more at ease.
Here are some questions to ask your doctor during your next appointment.

What Symptoms Will I Experience?

Chances are, it was your symptoms that helped your doctor diagnosis you in the first place. Not everyone experiences the same symptoms, so it can be difficult to predict how your disease will progress or exactly what symptoms you will feel. Your symptoms will also depend on the location of the affected nerve fibers.
Common signs and symptoms of MS include:
  • numbness or weakness, usually affecting one side of the body at a time
  • painful eye movement
  • vision loss or disturbances, usually in one eye
  • extreme fatigue
  • tingling or “prickly” sensation
  • pain
  • electric shock sensations, often when moving the neck
  • tremors
  • balance issues
  • dizziness or vertigo
  • bowel and bladder issues
  • slurred speech
While the exact course of your disease can’t be predicted, 85 percent of those with MS have relapsing-remitting multiple sclerosis (RRMS). RRMS is characterized by a relapse of symptoms followed by a period of remission that can last months or even years. These relapses are also called exacerbations or flare-ups.

What Are My Treatment Options?

There’s currently no cure, but there are many effective medications available to treat MS. The three main goals for treatment are to:
  • modify the disease course by slowing MS activity for longer periods of remission
  • treat attacks or relapses
  • manage symptoms
Disease-modifying therapies (DMTs) approved by the Food and Drug Administration can effectively decrease the number of relapses and slow progression of your disease. Some DMTs are given by a medical professional through an intravenous infusion, while others are given by injection at home.


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Saturday, May 12, 2018

Novartis announces FDA approval of Gilenya® as the first disease-modifying therapy for pediatric relapsing multiple sclerosis

 New approval for Gilenya (fingolimod) addresses strong unmet need for younger patients, who often experience more frequent relapses than adults with multiple sclerosis (MS)(1)

- In a landmark controlled Phase III study of children and adolescents (ages 10 to less than 18) with relapsing forms of MS (RMS), Gilenya reduced the annualized relapse rate by approximately 82% vs. interferon beta-1a injections (p< 0.001)(2)

- Gilenya is the most prescribed oral once-daily MS disease-modifying treatment, with a global exposure of more than 231,000 patients since its initial approval for adults with RMS(3)
 
NEWS PROVIDED BY
May 11, 2018, 18:35 ET
EAST HANOVER, N.J., May 11, 2018 /PRNewswire/ -- Novartis today announced that the US Food and Drug Administration (FDA) has approved Gilenya® (fingolimod) for the treatment of children and adolescents 10 to less than 18 years of age with relapsing forms of multiple sclerosis, making it the first disease-modifying therapy indicated for these patients2.
 
This approval expands the age range for Gilenya, which was previously approved for patients aged 18 years and older with RMS. Gilenya was granted Breakthrough Therapy designation by the FDA in December of 2017 for this pediatric indication.
 
"We now finally have an FDA-approved treatment for children and adolescents with relapsing MS," said Dr. Brenda Banwell, Chief of the Division of Neurology at Children's Hospital of Philadelphia, who served as co-Principal investigator of the pivotal study that supported the pediatric approval. "Repeated relapses are more common in young people with MS than in adults, so this is heartening news for patients and their families."

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Thursday, May 10, 2018

Dealing with Dizziness and Vertigo When You Live with MS

Many people with MS experience episodes of dizziness, which can make you feel lightheaded or off-balance. Some also have episodes of vertigo. Vertigo is the false sensation of whirling or spinning of yourself or the world around you. According to one report, about 20 percent of people with MS experience vertigo.
Dizziness and vertigo contribute to balance problems, which are common in people with MS. Ongoing dizziness and vertigo can interfere with daily tasks, increase the risk of falls, and can even become disabling.

What vertigo feels like

Vertigo is an intense sensation of spinning, even if you’re not moving. It’s similar to what you feel on a twirling amusement park ride. The first time you experience vertigo can be very unsettling, even frightening.
Vertigo may be accompanied by nausea and vomiting. It can continue for hours, or even days. Sometimes, dizziness and vertigo are accompanied by vision problems, tinnitus or hearing loss, or trouble standing or walking.

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Causes of dizziness and vertigo in MS
The lesions that result from MS make it difficult for nerves within the central nervous system to send messages to the rest of the body. This causes MS symptoms, which vary according to the location of the lesions. A lesion or lesions in the brain stem or cerebellum, the area of the brain that controls balance, may cause vertigo.
Vertigo can also be a symptom of a problem with the inner ear. Other possible causes of dizziness or vertigo include certain medications, blood vessel disease, migraine, or stroke. Your doctor can help you rule out other possible causes of vertigo.

Self-help measures


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Wednesday, May 9, 2018

How YOU Can Help Me Use My Voice as a Courageous Warrior

MS Patient Story
Written By: Cathy Chester - An Empowered Spirit

I never intended to share so much of myself with readers when I first created An Empowered Spirit, to reveal my hidden feelings, experiences, hopes, and dreams. I know it’s something good writers are supposed to do but it was difficult for me. Then I read a book that forever changed me, Elizabeth Lesser’s “Broken Open.” Her words gave me the courage to be frank, open and honest in my writing. In return, I’ve been rewarded with readers who tell me that my work as a health advocate has helped them feel less alone, more empowered and forever grateful.   
“Every catastrophe can hand us exactly what we need to awaken into who we really are.” ~Elizabeth Lesser
I’m about to break myself open again for a good reason. 
courageous
 I recently relocated to a new area of N.J. where I know almost no one. Being a freelance writer can be a lonely profession, so in my quest to meet new people I joined a wonderful organization called B.I.G. (Believe Inspire Grow) whose mission is, among other things, to help women live the way they were meant to live by providing inspiration, tools, community, and a whole lot more. I’ve met many wonderful, inspiring women and attended some fascinating and informative presentations.
READ MORE


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AAN Issues New Guidelines on Disease-Modifying Therapies in MS, Including Switching, Stopping and Pregnancy

30th April 2018

The new guideline aims to help clinicians choose among as many as two dozen potential therapies which, it is hoped, will delay disease progression, and help more patients avoid fearsome consequences like severe disability and reduce life expectancy. But doctors also face the challenge of limited follow-up for many of these drugs, one of which was recently voluntarily removed from the market due to side effects.
A new practice guideline published by the American Academy of Neurology on April 23 attempted to sort out recommendations among an explosion of drugs for multiple sclerosis which are considered to be disease-modifying therapies (DMTs) which have been approved in recent years. The guideline, which discussed clinical questions such as choice of therapies, as well as strategies including switching or stopping DMTs, was published during the Academy’s annual meeting in Los Angeles.
The guideline discussed 17 FDA-approved medications, and also made a weak recommendation regarding off-label use of six other drugs. (Patients may also have to take other drugs to treat their symptoms, which DMTs are not intended to address).
The cornucopia of new medications, at least seven of which have only been approved since 2010, has its origin in immune strategies.
“If you trace it back to the very first FDA-approved medicine, interferon in 1993, the scientists knew MS had something to do with the immune system,” said Alexander Rae-Grant, MD, professor of medicine at the Cleveland Clinic Lerner College of Medicine, and lead author on the article.
Another older drug, glatiramer acetate, was approved in 1996. “It is like a molecular mimic; it confuses the immune system into attacking the medicine, because it looks like myelin,” the substance that surrounds nerve cells, said Rae-Grant. “We know everything there is to know about that medicine.

“Since then, we’ve become much more targeted in our approach, and we’ve adapted some medications used in cancer populations, as well as rheumatology,” he added.
Head-to-Head Clinical Trials Urgently Needed
But much less is known about some of the newer medications, leading the members of the guideline committee to make recommendations about the need for clinical trials in areas like comparative effectiveness and pregnancy-related issues. And prior to just last year, with the approval of ocrelizumab, there was no DMT for the primary progressive form of MS. (A classification system for several varieties of MS was revised in 2016).
The uncertainty some clinicians may experience is illustrated by the voluntary withdrawal from the market of one drug, daclizumab, which was initially referred to in the guideline, according to Rae-Grant (daclizumab was first approved in 1997 for transplant patients).
Neurologists are hopeful that the new therapies will be life-changing for some patients. Perhaps the most feared consequences of MS are severe disability and a somewhat reduced life expectancy.
“It used to be that about half of the patients would not be able to walk independently after about 25 years. But we don’t have a lot of long-term data on the MS population,” noted Rae-Grant.
“If we go back to earliest therapies, some cohorts have been followed for 20 years. But some of the new DMTs have only been available for two-to-five years, and disease progression is typically measured by relapses which occur over two to three years,” explained Ruth Ann Marrie, MD, PhD, professor at the University of Manitoba in Winnipeg, and co-author on the article. “So it’s difficult to say what a new therapy is going to do for somebody 20 years from now.”
But neurologists are hopeful that patients will experience some long-term benefits, including a delay of progression. In determining how to do that, the experts debated questions like whether to prescribe the strongest therapies first, or to switch to them if less potent drugs stop working.

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Tuesday, May 8, 2018

Scientists Look at Regrowing Myelin as a Potential MS Treatment

A recent study showed the promise of remyelination, which could help reverse some of the damage done to the body by multiple sclerosis.


Have you heard of remyelination? It might be important if you have multiple sclerosis.
recent study in mice demonstrated the potential in remyelination, which is the growth of lost myelin.
The ability to regrow myelin could reverse the damages caused by multiple sclerosis (MS).
Simple gestures such as picking up the phone, walking, eating, and drinking require messages from the brain to the muscles and nerves. Messages throughout the body are sent via nerve synapses. When these synapses are unable to connect, the messages fail.
Nerves are protected by a fatty myelin sheath. As MS attacks and progresses, it destroys these sheaths and leaves the body vulnerable.
MS can be a progressive disease and its course can be ruthless.
Once the damage is done, there’s been no hope of reversal. But now this recent look at growing myelin shows some potential for humans.
Continue Reading


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Monday, May 7, 2018

Predicting Clinical Outcomes for Multiple Sclerosis Patients: Cutting-Edge Research at Hadassah

April 17, 2018
Groundbreaking research from Hadassah Hospital helps study clinical outcomes for newly diagnosed Multiple Sclerosis patients.
More than two million people--two to three times more women--have multiple sclerosis (MS)--the leading cause of neurological disability among young adults.  What is their prognosis?
“We don’t really know what an individual’s prognosis will be when we first diagnose the disease,” relates Dr. Adi Vaknin, Senior Neurologist at Hadassah Hospital Ein Kerem. That is because there is so much heterogeneity in outcomes, she explains. While 15 to 20 percent of MS patients do very well, 50 to 70 percent need strong medicines to live a quality life. It is this uncertainty that has led Prof. Vaknin to start a biobank with which to study clinical outcomes for newly diagnosed patients. By identifying a set of proteins (biomarkers) within an individual’s peripheral blood, Dr. Vaknin and her research team have been able to predict, for example, a patient’s response to interferon, a common treatment for MS.
  Dr. Adi Vaknin
The past 15 years have seen the development of very effective medications to treat MS. Currently, Dr. Vaknin reports, there are 10 medications available, but their effectiveness varies from person to person. “There is also a limited time window to start treatment,” Dr. Vaknin says, “because if you miss that window, some of the medicines are not very effective.” There are, however, two new medications on the market, she notes, specifically designed to treat progressive MS.
One common thread in MS is the degeneration of myelin, the sheath that protects the nerve fibers.  Dr. Vaknin is researching the ability of certain proteins, found in the fluid surrounding the brain, to renew damaged myelin. Being able to rebuild myelin in MS patients is only in the research stage--though she estimates that “it will happen in the next five years.”
In the meantime, what advice does Dr. Vaknin have for those who suffer with MS? She recommends 2,000 units per day of Vitamin D--particularly found to be effective in preventing the occurrence of the disease in any offspring. Dr. Vaknin also suggests exercise and a healthy diet--and no smoking. She adds living a less stressful life to the list, but acknowledges that this “is not so easy to do.”  
Source

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Sunday, May 6, 2018

#AAN2018 — Ocrevus Lowers Immune Response to Vaccines in Relapsing MS, Phase 3 Trial Shows

Treatment with Ocrevus (ocrelizumab) is linked to a reduced immune response to vaccinations in patients with relapsing multiple sclerosis (MS), according to a Phase 3 trial.
These results were recently presented at the 2018 American Academy of Neurology (AAN) Annual Meeting in Los Angeles in a presentation titled, “Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis.
Genentech’s Ocrevus is an approved MS therapy that targets the CD20 protein located on the surface of B-cells, targeting the cells for destruction. B-cells are immune system cells involved, for example, in the production of antibodies necessary to fight off infection.
At the AAN meeting, researchers reported that in MS patients, treatment with Ocrevus decreased the ability of B-cells to activate other immune cells, improving the rate of MS attacks. Penn Medicine neurologist Amit Bar-Or, MD, presented these findings, which showed that interactions between different classes of immune cells, such as B- and T-cells, promote MS attacks.
Vaccination against infections is an important part of the management of patients with MS. So, in a second study (NCT02545868), researchers investigated the impact treatment with Ocrevus has on patient response to vaccines.
Read More

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