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Thursday, August 14, 2008
High-dose cyclophosphamide shows promise for aggressive Multiple Sclerosis
Date: 13 August 2008
High-dose cyclophosphamide, aimed at immune system ablation, is a safe and well-tolerated treatment for aggressive multiple sclerosis that can markedly reduce disease activity and disability, according to the results of a small, open-label trial.
In an earlier study of 13 patients with severe refractory multiple sclerosis, treatment with high-dose cyclophosphamide followed by granulocyte colony-stimulating factor often stabilized or improved disability. The current study investigated the safety and efficacy of this treatment further by examining clinical and radiologic features not previously studied and by including a longer follow-up period.
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