Neurology. 2008 Sep 24. [Epub ahead of print]

Rovaris M, Riccitelli G, Judica E, Possa F, Caputo D, Ghezzi A, Bertolotto A, Capra R, Falautano M, Mattioli F, Martinelli V, Comi G, Filippi M.

OBJECTIVE: Although in benign multiple sclerosis (BMS) locomotor disability is absent or only minimal, subclinical cognitive impairment seems to occur in many cases. Diffusion tensor (DT) MRI enables us to quantify the extent of "actual" tissue damage, which goes undetected when using conventional MRI. Against this background, we investigated the extent of structural brain damage underlying cognitive dysfunction in BMS, with the ultimate aim to move a first step toward a more reliable definition of this disease phenotype.

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