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Tuesday, December 2, 2008

Switching first-line disease-modifying therapy after failure

Switching first-line disease-modifying therapy after failure: impact on the course of relapsing-remitting multiple sclerosis.

Gajofatto A, Bacchetti P, Grimes B, High A, Waubant E.

Multiple Sclerosis Center, Department of Neurology, University of California, San Francisco, California, USA; Department of Neurological and Vision Sciences, University of Verona, Verona, Italy.

Background - Options for non-responders to relapsing-remitting multiple sclerosis (RRMS) first-line disease-modifying therapies (DMT) are limited. We explored whether switching first-line DMT is effective.MethodsPatients with RRMS who first received interferon-beta (IFNB) or glatiramer acetate (GA) were classified in three categories: DMT change because of suboptimal response, DMT change because of other reasons, and no DMT change during follow-up.

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