Pubmed
Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis
The role of genes in the pathogenesis of MS is complex. The authors found an association between a gene called Atg5 and MS, suggesting that it may contribute to inflammation in MS.
authors: Alirezaei M, Fox HS, Flynn CT, Moore CS, Hebb AL, Frausto RF, Bhan V, Kiosses WB, Whitton JL, Robertson GS, Crocker SJ
source: Autophagy. 2009 Feb 5;5(2).
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, USA.
Multiple sclerosis (MS) is an inflammatory central nervous system (CNS) disorder characterized by T cell-mediated demyelination. In MS, prolonged T cell survival and increased T cell proliferation have been linked to disease relapse and progression.
Recently, the autophagy-related gene 5 (Atg5) has been shown to modulate T cell survival. In this study, we examined the expression of Atg5 using both a mouse model of autoimmune demyelination as well as blood and brain tissues from MS cases.
Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis
The role of genes in the pathogenesis of MS is complex. The authors found an association between a gene called Atg5 and MS, suggesting that it may contribute to inflammation in MS.
authors: Alirezaei M, Fox HS, Flynn CT, Moore CS, Hebb AL, Frausto RF, Bhan V, Kiosses WB, Whitton JL, Robertson GS, Crocker SJ
source: Autophagy. 2009 Feb 5;5(2).
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, USA.
Multiple sclerosis (MS) is an inflammatory central nervous system (CNS) disorder characterized by T cell-mediated demyelination. In MS, prolonged T cell survival and increased T cell proliferation have been linked to disease relapse and progression.
Recently, the autophagy-related gene 5 (Atg5) has been shown to modulate T cell survival. In this study, we examined the expression of Atg5 using both a mouse model of autoimmune demyelination as well as blood and brain tissues from MS cases.
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