According with Elaine Delack, RN it is:
In layman's terms, Ramagopalan and associate scientists report that persons having the HLA-DRB1*1501 gene are more likely to develop MS than those who don't have this gene. Those people who have two copies of this gene have even a greater risk of MS. Ramagopalan et al found that if vitamin D was given to cells that had two copies of this gene (HLA-DRB1*1501) that this would increase the activity of this gene even more.
Thus, their findings show that vitamin D will increase the gene expression activity of the HLA-DRB1*15 and this would put a person at greater risk of developing MS since increased HLA-DRB1*15 expression predisposes a person to the risk of developing MS.
Yet they state in their conclusion of their study that vitamin D would decrease the risk. This is not correct based on their study findings and instead supplementation with vitamin D could actually potentiate the development of MS.
Their findings that vitamin D can increase the HLA-DRB1*15 protein production which would increase a person's risk of developing MS is congruent with the trends that are seen in MS. MS is predominantly a Caucasian disease and the more fair-skinned persons have a higher incidence. Vitamin D serum levels are higher in light skinned persons than in darker skinned persons due to the melanin that inhibits the production of vitamin D in the darker skinned persons.
Elaine
If you have questions or comments for Elaine, you can write to her at:
elaine@edmsllc.com OR leave a comment , below...
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