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Thursday, April 16, 2009

Rebif or Avonex®? — Comparative efficacy

Superior relapse outcomes versus Avonex
  • In the head-to-head EVIDENCE study, patients who received Rebif 44 mcg tiw (n=339) had a 30% reduced risk of relapse compared with patients who received Avonex (n=338) over an average of 64 weeks (P=0.002)[1]

Significantly reduced risk of relapse with Rebif 44 mcg vs Avonex over an average of 64 weeks
Significantly reduced risk
Results from the EVidence of Interferon Dose-response: European North American Comparative Efficacy (EVIDENCE) study.
Adapted from Panitch et al, 2005.[1]
For full study design and description, click here.

Superior MRI outcomes versus Avonex

  • A significantly greater percentage of Rebif 44 mcg tiw patients had no new T2 active lesions vs Avonex patients over an average of 64 weeks (58% vs 38%; P<0.001)[1]

Proportion of patients with no new T2 active lesions over an average of 64 weeks
Significantly reduced risk of relapse with Rebif 44 mcg vs Avonex
Adapted from Panitch et al, 2005.[1]
For full study design and description, click here.
The exact correlation between MRI findings and the current or future clinical status of patients, including disability progression, is unknown.
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