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Tuesday, April 14, 2009

Stem Cells Offer Potential Multiple Sclerosis Treatment

Cells that produce myelin can be generated from human embryonic stems cells

MONDAY, April 13 (HealthDay News) -- Oligodendrocytes generated from human embryonic stem cells that produce myelin offer novel possibilities for basic and clinical research into treatments for multiple sclerosis, but the process is more protracted than in mouse cells, according to a study published online April 10 in Development.

Bao-Yang Hu, of the University of Wisconsin in Madison, and colleagues used human embryonic stem cells to see if a process already achieved in mouse embryonic stem cells, which turns them into oligodendrocytes, could be replicated in human cells.

Although the process was more protracted than in mice embryonic stem cells, the researchers were able to develop oligodendrocytes from human embryonic stem cells using the same technique of exposure to the sonic hedgehog protein. The process took 14 weeks in human cells versus two weeks in mouse cells, and whereas the growth factor FGF2 promoted oligodendrocyte production in mouse embryonic stem cells, it stalls the process in human embryonic stems cells, the investigators found.

"This was quite a surprise given that this is exactly how we direct mouse embryonic stem cells to become oligodendrocytes. But we have discovered an unexpected twist in the cell's response to the same external factor," said Su-Chun Zhang, M.D., one of the study's authors, in a statement. "It nevertheless explains why so many research groups have failed to persuade human neural stem cells to become oligodendrocytes for the past decade."

Source: Modern Medicine

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1 comment:

Ray mumme said...

Stem Cell Research is the future and the direction that we should be going.
Embryonic Stem Cells on one hand has shown great result in the test tube, but when injected into living beings have proven not to proliferate but do just the opposite. Plus we have many ethical issues with going in this direction.

With Adult Stem Cells, stem cells already present in your bone marrow scientist have shown great results, to date. All the private money sector is going in this direction of research.

This is an excerpt from a peer review publication showing applications of Adult Stem Cells that produce therapeutic benefit for human patients.

Saccardi R et al., Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact
on disease activity and quality of life, Blood 105, 2601-2607, 15 March 2005
Burt RK et al., “Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation:
getting closer to a cure?”, Blood 99, 768-784, 1 February 2002
Mancardi GL et al.; “Autologous hematopoietic stem cell transplantation suppresses Gd-enhanced MRI
activity in MS”; Neurology 57, 62-68; July 10, 2001
Rabusin M et al.; “Immunoablation followed by autologous hematopoietic stem cell infusion for the
treatment of severe autoimmune disease”; Haematologica 85(11 Suppl), 81-85; Nov. 2000
Burt, RK and Traynor, AE; “Hematopoietic Stem Cell Transplantation: A New Therapy for Autoimmune
Disease”; Stem Cells17, 366-372; 1999
Burt RK et al.; “Hematopoietic stem cell transplantation of multiple sclerosis, rheumatoid arthritis, and
systemic lupus erythematosus”; Cancer Treat. Res. 101, 157-184; 1999

For the full study please email me are for other adult stem cell break throughs. at