Published: July 29, 2009
Reviewed by Zalman S. Agus, MD; Emeritus Professor
University of Pennsylvania School of Medicine.
WHEELING, W.Va., July 29 -- Regular neurocognitive screening and MRI scans may be able to spot patients with so-called benign multiple sclerosis who will soon develop significant disabilities, researchers said.
Among 63 patients diagnosed with benign MS at baseline, 29% developed disabling symptoms during mean follow-up of five years, reported Maria Pia Amato, MD, of the University of Florence, Italy, and colleagues online in Neurology.
They found that T1-weighted brain lesion volume detected on MRI scans, the number of neurocognitive tests failed at baseline, and male gender, were each significantly predictive of disease progression.
A model combining all three predictors distinguished those who progressed with an accuracy of 82%, the researchers reported.
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