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Thursday, October 15, 2009

Research being conducted to learn if: MS is a chronic cerebral spinal venous insufficiency

Info provided by SammyJo in Ca.


2009 MRI CCSVI Pilot Study with MRA and SWI
In the last few years, I have been proposing that venous damage in multiple sclerosis is implicated by increased iron content in the basal ganglia and thalamus. But the interest and association of MS with veins dates back to Fog (1) in 1964 with a major decade's long effort to convince people of the role of the mechanical effects of changes in venous flow by Schelling (2).

However, the excitement comes from a proof of concept that MS is a chronic cerebral spinal venous insufficiency (CCSVI) by Paolo Zamboni and his team (3). This exciting work done with ultrasound and followed by a corrective surgical procedures shows that we should have been looking outside the box (brain) to find the problem in the brain.

There is a great deal of evidence in both atherosclerosis and chronic venous disease that changes in shear stress can cause a biological response that is very similar to what we see in MS (see for example the work by John Bergan (4)). In fact, it is a logical explanation as to why the entire brain is affected in MS, why the disease tracks backward along the venous drainage system, and why it emanates from the white matter near the ventricles in the drainage of territory of the medullary veins. If the thalamostriate system is affected with increased iron content along the venous system as I believe it is, then this all falls into place. CCSVI may just be the etiological source we have all been looking for. If so it provides great hope for MS patients worldwide and we cannot and should not wait years for funding to allow us to demonstrate this point. We need to establish an international protocol to attack this as the torch bearers for people suffering from MS.

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2 comments:

Christian said...

The University of Buffalo put out a press release ont he BNAC CTEVD study yesterday. It is in it's entirety here: http://www.buffalo.edu/ubreporter/2009_10_14/ms_study

Heil Luthringer Foundation said...

There are 6000 people who live in Buffalo with MS. I garduated from UB in Nursing and have MS. I thhink UB is spot on in its research and its support for MS. I have Hope that we can find a cause and cure for MS, Love for the researchers putting their hearts and souls in their work, and Faith in God. GO UB!!!