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Friday, July 2, 2010

Research News on Oral MS Therapies

 The National MS Society and
MS LEARN ONLINE present...
Research News on Oral Therapies

A new Feature Presentation:
 

A video webcast that explores:
  • Oral therapies currently in clinical trials
  • Oral therapies on the horizon
  • Who are they for and what are they?
     
Click here to view the webcasts, or copy into your browser: http://www.nationalmssociety.org/multimedia-library/ms-learn-online/index.aspx
 
 
 
If you have a pop-up blocker, you will need to disable it prior to participating in a MS Learn Online webcast



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Brain atrophy responsible for depression in people battling multiple sclerosis

Study finds hippocampus is affected by imbalance in neuroendocrine system

Adding to all that ails people managing their multiple sclerosis is depression ― for which MS sufferers have a lifetime risk as high as 50 percent.

Yet despite its prevalence, the cause of this depression is not understood. It's not related to how severe one's MS is, and it can occur at any stage of the disease. That suggests it is not simply a psychological reaction that comes from dealing with the burden of a serious neurologic disorder.
Now, in the first such study in living humans, researchers at UCLA suggest a cause, and it's not psychological, but physical: atrophy of a specific region of the hippocampus, a critical part of the brain involved in mood and memory, among other functions.

Reporting in the early online edition of the journal Biological Psychiatry, senior study author Dr. Nancy Sicotte, a UCLA associate professor of neurology, Stefan Gold, lead author and a postdoctoral fellow in the UCLA Multiple Sclerosis Program, and colleagues used high-resolution magnetic resonance imaging to identify three key sub-regions of the hippocampus that were found to be smaller in people with MS when compared with the brains of healthy individuals.

The researchers also found a relationship between this atrophy and hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, a complex set of interactions among three glands. The HPA axis is part of the neuroendocrine system that controls reactions to stress and regulates many physiological processes. It's thought that this dysregulation may play a role in the atrophy of the hippocampus and the development of depression.

"Depression is one of the most common symptoms in patients with multiple sclerosis," Gold said. "It impacts cognitive function, quality of life, work performance and treatment compliance. Worst of all, it's also one of the strongest predictors of suicide."


Continue from Eureka Alerts

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Progressive forms of Multiple Sclerosis may have new and viable treatment options

July 1, 1:31 PMLima Multiple Sclerosis ExaminerLori Friend



Dr. Saud A Sadiq, of the Multiple Sclerosis Research Center of New York(MSRCNY), has this to say about their new findings, "We have opened an avenue of treatment for an otherwise untreatable form of MS. This is exciting news because it's the first time a treatment has been shown to be effective in the late stages/progressive forms of MS."
The MSRCNY and the International Multiple Sclerosis Management Practice(IMSMP) put together what is called a retrospective, open-label, chart review case study of MS patients and intrathecal methotrexate(ITMTX).
The study followed 87 patients with secondary-progressive MS and 34 patients with primary- progressive MS for about 8 treatments of the ITMTX along with a one year follow-up after that 8th treatment or their last treatment.
The patients were given Expanded Disability Status Scale (EDSS) evaluations which showed stability or improvement in 89% in the secondary-progressive patients and 82% in the primary-progressive.  There were significant improved means EDSS post-treatment scores within the 1st group, but they found the 2nd group didn't show as much of a change as the 1st group post-treatment.

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Thursday, July 1, 2010

Social Security is still a prime target for cuts

For 75 years, seniors have been able to count on Social Security benefits, even in the toughest times. That's why I'm so concerned about the deficit commission's meeting next week.
The commission has been charged with balancing the nation's budget – and, under pressure to find cuts in federal spending, Social Security is a prime target.
Social Security didn't cause the deficit – these benefits shouldn't be cut to fix it.
Over the next few months, the National Commission on Fiscal Responsibility will continue meeting to develop recommendations on how to cut the federal deficit, and the risk to Social Security couldn't be higher.
Many members of the commission support cuts to Social Security benefits, including co-chair Alan Simpson, an outspoken critic of the program.
After a lifetime of hard work contributing to Social Security, you, your family and your friends deserve every cent you've earned.
I know you care about America's financial security – and so do we. But our leaders in Washington should crack down on earmarks and wasteful government spending – not Social Security.
Thank you for joining us in this fight. Together we can keep Social Security strong for today's seniors, and generations to come.
Sincerely,
Barry Jackson
Senior Manager, Grassroots



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Polar MS resources and Cooling Products

Polar MS Resources

Wednesday, June 30, 2010

Montel Williams lobbies State of New York to legalize medical marijuana

June 29, 2010

Montel Williams, the former talk show host who now suffers from multiple sclerosis, is making the rounds here at the State Capitol today in hopes of encouraging the legalization of medical marijuana in New York.

Williams, who uses marijuana to ease the effects of his condition, noted 14 states and the District of Columbia have passed MM laws, and many other state legislatures are now considering it.

It's questionable whether the New York measure will make it through, and officials including Mayor Bloomberg have issued strenuous objections to its passage.

I had a chance to chat briefly with Williams, who says he's not giving up hope.



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German pharmaceuticals and chemicals company Merck KGaA is banking on an experimental multiple sclerosis (MS) pill to lift operating margins


(Reuters) - German pharmaceuticals and chemicals company Merck KGaA is banking on an experimental multiple sclerosis (MS) pill to lift operating margins at its embattled drugs unit, it said on Wednesday.

Earnings before interest, tax and special items at its Merck Serono prescription drugs unit could rise to 25 percent of sales in the long term, up from 22.4 percent in the first quarter, analysts at Exane BNP Paribas quoted the unit's head, Elmar Schnee, as saying in remarks confirmed by a Merck spokesman.

Merck resubmitted the U.S. application for its MS pill cladribine on June 8, trying to catch up with Novartis AG in the race to bring to market the first oral treatment against the debilitating disease.

If key pipeline drugs such as cladribine get rejected by regulators the margin could be 20 percent in the long term, Schnee said.

CONTINUE READING


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Cancer Drug Shows Promise for Treating a Wide Range of Inflammatory Diseases

ScienceDaily (June 30, 2010) — Those looking for a new treatment for a range of inflammatory diseases like arthritis, multiple sclerosis, inflammatory bowel disease, and lupus may need to look no further than a drug already available for treating cancer.


In a research report published in the July 2010 print issue of the Journal of Leukocyte Biology, Japanese scientists use mice to show that bortezomib, currently used to treat cancers that affect white blood cells, induces cell death only in harmful (active and proliferating) T cells, leaving the rest unharmed. If the results prove true in humans, it offers hope that this drugs or others similar to it might be used to treat inflammatory diseases without the side effects of current drugs that affect all T cells equally.


"Unfortunately, there are a lot of people who are suffering from autoimmune and inflammatory disease," said Koichi Yanaba, M.D., Ph.D., a scientist from the Department of Dermatology at Nagasaki University Graduate School of Biomedical Sciences who was involved in the research. "We believe that this new-type remedy for autoimmune and inflammatory disease could successfully treat them in the near future."


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UNIVERSAL HEALTH CARE PROGRAM, evidently is not for "everybody"

Send  this one on every time you receive it, it seems to take some people  longer to "wake up than others!"  
 
 FINALLY SOMEONE ASKED HIM THE  QUESTION! ON "ABC-TV"  - by  Charlie Gibson.   
 He loves  Obama. DURING THE "NETWORK  SPECIAL ON HEALTH CARE".... OBAMA WAS ASKED:
  
 
 "MR PRESIDENT WILL YOU AND  YOUR FAMILY GIVE UP YOUR CURRENT HEALTH CARE PROGRAM AND  JOIN THE NEW 'UNIVERSAL HEALTH CARE PROGRAM' THAT THE REST OF US  WILL BE ON ????"   

  THERE WAS A STONEY  SILENCE AS OBAMA IGNORED THE QUESTION AND CHOSE NOT TO ANSWER  IT !!! IN ADDITION, A NUMBER OF  SENATORS WERE ASKED THE SAME QUESTION AND THEIR RESPONSE  WAS."WE WILL THINK ABOUT IT." AND THEY DID. IT  WAS ANNOUNCED TODAY ON THE NEWS THAT THE "KENNEDY HEALTH CARE  BILL" WAS WRITTEN INTO THE NEW HEALTH CAREREFORM INITIATIVE  ENSURING THAT THAT CONGRESS WILL BE  100% EXEMPT !
SO, THIS GREAT NEW  HEALTH CARE PLAN THAT IS GOOD FOR YOU AND ME BUT IS NOT GOOD ENOUGH  FOR OBAMA, HIS FAMILY OR CONGRESS!!!

WE (THE AMERICAN  PUBLIC/PEOPLE) NEED TO STOP THIS PROPOSED DEBACLE ASAP !!!!   THIS IS TOTALLY WRONG !!!!!

PERSONALLY, I CAN ONLY  ACCEPT A UNIVERSAL HEALTH CARE OVERHAUL THAT EXTENDS TO EVERYONE...  NOT JUST US LOWLY CITIZENS.... WHILE THE WASHINGTON "ELITE"  KEEP RIGHT ON WITH THEIR GOLD-PLATED HEALTH CARE  COVERAGES.

If you don't pass this  around, may you enjoy his Plan

!

  
WHAT???   The Republic has a  CONSTITUTION???
 
 Amendment  28

Congress shall make no law that applies to the  citizens of the United States that does not apply equally to  the Senators or Representatives, and Congress shall make no law  that applies to the Senators or Representatives that does not  apply equally to the citizens of the  United States  .
 
Imagine  what would happen if everybody passed this  around


FIND A WAY to SHARE this information with others you know.
Comments welcomed !!!


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Monday, June 28, 2010

Meat, Sausage and other foods can heighten risks of Multiple Sclerosis

June 27, 2010 - BY Debbie Nicholson

Opinion from examination of information from seven EU countries introduced today by German epidemiologist Dr. Klaus Lauer, at the 20th Meeting of the European Neurological Society (ENS) in Berlin, Germany, stated that the facts presented as of currently are not affirmed informal link, but is an expressive implication that a link possibly does exist and needs to be completely researched.

Research data had implied that particular industrial manufacture foods such as chocolate, jam, margarine and sausage, corresponds statistics with heightened chances of multiple sclerosis. 

During the “ecological study”, the epidemiological examination of information gathered of major regions or population groups, information on industrial food manufacturing in seven countries were analyzed for likely MS relationships with reversed results.

A major heightened occurrence was found associated with MS and the dispersion of raw vegetable oils, fats, butter, cheese, condensed milk, canned vegetables and more. 

Continue reading from All Voices.com

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