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Disclaimer: 'MS Views and News' DOES NOT endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, for your personal knowledge and to keep you informed of current health-related issues. It is not a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.

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Friday, September 17, 2010

MS gene revealed by chance

By Elise Stolte, Edmonton Journal September 17, 2010

A surprise discovery by a young researcher at the University of Alberta has opened a new area of research into multiple sclerosis.
PhD student Allison Kraus, 26, was studying the gene calnexin under her supervisor Marek Michalak.

They discovered that when they disabled the gene in mice, the animals had mobility issues -- trouble walking and paralysis in their back legs -- similar to what patients with multiple sclerosis and other related diseases often experience.

Looking closer, they found that silencing the gene had caused the protective sheath, or myelin, around the mouse nerves to deform, which disrupted the nerve signals and caused the mobility issues. Those same deformations are found in humans with multiple sclerosis and other related diseases.

"It was actually a very exciting finding," said Michalak. "This really was from curiosity-driven research. It would not have been predictable.

"This is an example of taking risks and winning."

The U of A researchers are still far from finding new treatments for MS, but they are closer to understanding what might cause the disease, said Michalak. The lab's next step will be to take nerve samples from human subjects and confirm that the deformities found in the lab mice and humans are the same. If that is the case, this would be a big discovery that would change how scientists think about MS, he said.


Continue to read



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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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Not Sure if you are affected by Spasticity?

For many of us with Multiple Sclerosis we live with Pain. Sometimes this pain is caused by Muscle cramps. Others may have stiffness or having difficulty moving your arms or legs, don't know how you will get out of bed and so much more ...

If you are not sure if this could be Spasticity, then please look and respond to this Spasticity screening questionnaire..

Having MS and/or  Spasticity may not mean giving up on things you like-to or want-to do in life...



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"Providing You with 'MS Views and News'is what we do"
Keep Informed and up-to-date with information concerning
 Multiple Sclerosis when registered at
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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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About ITB Therapy for Spasticity


When you choose Medtronic ITB TherapySM (Intrathecal Baclofen Therapy), you are joining thousands of others who depend on this technology to loosen overly tight muscles, which may minimize spasticity-related pain. The key is a surgically placed pump that continuously delivers medication to your spinal cord fluid.

What Is It?


ITB Therapy (the baclofen pump) is a precise, targeted treatment proven to reduce severe spasticity.1-9

Our Baclofen Pump


The Medtronic SynchroMed® pump is a programmable, battery-powered medical device that stores and delivers a prescription medication called Lioresal®Intrathecal (baclofen injection). It is surgically placed in the abdomen. A thin, flexible silicone tube called a catheter is inserted near the spine and connected to the pump.

CONTINUE Reading from the Medtronic website - to learn of benefits vs risks, Questions and answers..

Click the other tabs on their website for Getting or Living with the Therapy.


Share what you are reading here (from Stu's Views & M.S. News)  with others who might be affected by Spasticity.


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"Providing You with 'MS Views and News'is what we do"
Keep Informed and up-to-date with information concerning
 Multiple Sclerosis when registered at
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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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Treatment Options for Severe Spasticity


People with spasticity can treat their condition in many ways: rehabilitation, medication, injection therapy, even surgery. There is also Medtronic ITB TherapySM (Intrathecal Baclofen Therapy), also called the baclofen pump, which may be helpful for reducing your severe spasticity.
There is currently no cure for severe spasticity. However, there are a number of treatment options available for managing your symptoms. They include:

Rehabilitation Therapy

Rehabilitation therapy usually takes place in a clinic, a hospital, or at home. It can include any combination of physical, occupational, or speech therapy.

Oral Medication

Oral medications may help some people treat the symptoms of spasticity.

Neurosurgeries

Neurodestructive surgical procedures include selective dorsal rhizotomy, in which the dorsal (sensory) nerve roots are severed.

Injection Therapy

Injection therapy is usually intended for specific muscle groups (for example, one hand, one foot, one shoulder).

Orthopedic Surgery

Orthopedic surgeries include soft tissue procedures like tendon transfers and osteotomies (cutting a bone to change its alignment).

ITB Therapy (Baclofen Pump)

Medtronic ITB Therapy, also called the baclofen pump, is an adjustable, reversible treatment for severe spasticity. A surgically placed pump and catheter deliver liquid baclofen (Lioresal® Intrathecal) directly to the fluid around the spinal cord, where it’s needed most.

More About Treatment Options

Learn more about treatment options for severe spasticity by listening to a Medtronic Movement for Living presentation.

OUR Next posting will be about the ITB Therapy... Visit this Blog to read


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"Providing You with 'MS Views and News'is what we do"
Keep Informed and up-to-date with information concerning
 Multiple Sclerosis when registered at
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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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Spasticity and Multiple Sclerosis

Stuart Says: If you awake most nights with leg cramps in the backs of your thighs, your calves and or your feet and toes, then I suggest that you read the information found here and then on the subsequent posts that will follow this, on topics such as treatment options...Visit our (this) blog to read-up on Spasticity.


ABOUT SEVERE SPASTICITY
Source: Medtronic

Living with severe spasticity poses difficult physical challenges. Tight, stiff muscles can get in the way of daily activities. Fortunately, there is a therapy from Medtronic that can minimize severe spasticity in some individuals.
 

Definition

Spasticity is often described as tight, stiff muscles or spasms that may make movement, posture, and balance difficult. It may affect your ability to move one or more of your limbs, or to move one side of your body. Sometimes spasticity is so severe that it gets in the way of daily activities, sleep patterns, and caregiving.

Causes

Spasticity is caused by damage or injury to the part of the central nervous system (the brain or spinal cord) that controls voluntary movement. This damage disrupts important signals between the nervous system and muscles, creating an imbalance that increases muscle activity or spasms.

Risk Factors

Severe spasticity is associated with the following conditions:

Symptoms

Symptoms of spasticity may include:1
  • Increased muscle tone
  • Overactive reflexes
  • Involuntary movements, which may include spasms (brisk and/or sustained involuntary muscle contraction) and clonus (series of fast involuntary contractions)
  • Pain
  • Decreased functional abilities and delayed motor development
  • Difficulty with care and hygiene
  • Abnormal posture
  • Contractures (permanent contraction of the muscle and tendon due to severe persistent stiffness and spasms)
  • Bone and joint deformities

Diagnosis

Spasticity is typically diagnosed after the onset of a neurological condition. Your doctor will review your medical history and perform a physical evaluation. Your doctor may consider medications you have taken and whether there is a history of neurological or muscular disorders in your family. To confirm the diagnosis, tests can be performed to evaluate arm and leg movements, muscular activity, passive and active range of motion and ability to perform self-care activities.1

Reference

  1. WebMD Pain Management Health Center. Pain Management: Spasticity. Available at: www.webmd.com. Accessed August 15, 2008.



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"Providing You with 'MS Views and News'is what we do"
Keep Informed and up-to-date with information concerning
 Multiple Sclerosis when registered at
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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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Thursday, September 16, 2010

New focus on the immune system's ability to both unleash and restrain its attack on disease

Discovery Highlights Promise of New Immune System-Based Therapies

ScienceDaily (Sep. 15, 2010) — A new focus on the immune system's ability to both unleash and restrain its attack on disease has led Dana-Farber Cancer Institute scientists to identify cells in mice that prevent the immune system from attacking the animals' own cells, protecting them from autoimmune diseases such as multiple sclerosis, type 1 diabetes, and lupus.


CLICK here to continue


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"Providing You with 'MS Views and News'is what we do"
Keep Informed and up-to-date with information concerning
 Multiple Sclerosis when registered at
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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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Wednesday, September 15, 2010

Immunosuppresant vs. Myelin Repair: What is the difference?

Posted by: Megan Rechin - Tuesday, September 14th, 2010


    Multiple sclerosis is a complicated neurodegenerative disease for many reasons. For one, no one
knows exactly what causes MS to happen in seemingly healthy people. Or, why it affects people to varying degrees and extents. But as with most diseases, ideas are hypothesized from all different perspectives to develop a cure or treatment. One of the hypothesized

 treatments that are being tried out currently is the immunosuppressant drug.

    An immunosuppressant drug is a substance that blocks certain factors in the immune system that contribute to the inflammatory response in the human body. For example, when someone receives an organ transplant, they are put on an immunosuppressant so their immune system does not attack the new organ, as a result of an inflammatory response. These drugs are also used to treat severe cases of MS.

    On the market right now there are a broad range of immunosuppressant drugs. And, although a few have shown some sort of benefit to people with MS, there are many more that produce high side effects and intensify the susceptibility of infection. A lot of the immunosuppressant drugs are given along with the warning that they can have toxic side effects including hair loss, nausea, infertility and lung scarring. During clinical trials these drugs have had some benefit for people with very severe MS, but most patients believe that these small benefits may not outweigh the side effects. That is why, though there may be some good prospect with the immunosuppressant drugs, the MRF chose to research myelin repair instead.


Continue reading from the Myelin Repair Foundation website's


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"Providing You with 'MS Views and News'is what we do"
Keep Informed and up-to-date with information concerning
 Multiple Sclerosis when registered at
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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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