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Disclaimer: 'MS Views and News' DOES NOT endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.

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Saturday, November 27, 2010

"On Stage Live" variety show aids fight against multiple sclerosis


First, his sister-in-law was diagnosed. Then his brother. And then his wife, Cindy, was diagnosed with multiple sclerosis.
By that point, Teddy Davis and his family had a choice: They could plunge their heads deeply into the sand, or they could make a clear-eyed assessment of the situation and then do something about it.
“So, it was like, OK, there’s no point in just sitting around and watching all this happen,” he explained. “Let’s make a difference, let’s see if we can find a cure for this disease. They need money? OK, let’s see if we can raise some money.”
Davis, who lives in Aspen, organized On Stage Live three years ago. It’s a variety show with proceeds going to multiple sclerosis research. On Friday, Nov. 26, On Stage Live 2010 will come to Grand Junction’s Avalon Theatre.
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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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Friday, November 26, 2010

FDA extends priority review of Merck KGaA's MS pill


FRANKFURT, Nov 26 (Reuters) - The U.S. drugs watchdog will take more time to decide over Merck KGaA's (MRCG.DE) multiple sclerosis (MS) pill, the German company said on Friday, two months after drawing a rejection from European regulators.
The U.S. Food and Drug Administration (FDA) extended its review period for cladribine pills as a therapy for relapsing forms of (MS) by three months to Feb. 28, 2011, Merck said.
"The FDA extended the review period to provide additional time for a full review of additional information provided under the new drug application," the company added.
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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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Wednesday, November 24, 2010

Newfoundland enrolling patients in 'liberation' therapy study


The Canadian Press

Date: Wednesday Nov. 24, 2010 
ST. JOHN'S, N.L. — Multiple sclerosis patients in Newfoundland and Labrador have begun enrolling in an observational study of so-called liberation therapy.

The province's Health Department says 10 patients have enrolled in the study, eight of whom will undergo the procedure.
The department says it expects 30 patients will be needed to complete the study.

The provincial government announced in September that it would spend $320,000 to fund the study.

Liberation therapy, developed by Italian doctor Paolo Zamboni, involves widening constricted neck veins to improve blood flow from the brain.

The purpose of the study is to help determine the impact, if any, liberation therapy has on the mental and physical status of patients with multiple sclerosis.

The treatment has not yet undergone clinical trials in Canada, prompting some multiple sclerosis patients to seek it in clinics overseas.

Source: CTV News


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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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Assessing Cognitive Dysfunction in Patients With Multiple Sclerosis

Information provided by (our Ask the MS Nurse): Cherie C. Binns RN BS MSCN



SAN ANTONIO—The Mini-Mental Status Examination (MMSE) is not sufficiently sensitive to identify cognitive dysfunction in a small sample of patients with multiple sclerosis (MS), researchers reported at the 24th Annual Meeting of the Consortium of Multiple Sclerosis Centers. Thus, patients with MS should undergo an objective cognitive screening test, according to Corey Burchette, PsyD, of the Multiple Sclerosis Center, Neurology Center of Fairfax in Virginia, and colleagues.

Detecting Cognitive Impairment in MS
The study evaluated the effectiveness of two proposed cognitive screening test batteries in comparison to a full neuropsychologic evaluation in a group of 10 patients with MS (mean age of 41 and mean of 17 years of education). Both batteries included the MMSE, a verbal fluency test, Boston Naming test, and Trail Making Test (parts A and B). One also included the Beck Depression Inventory and Hopkins Verbal Learning Test, while the second battery included the Geriatric Depression Scale and Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) Word List Memory test.

All 10 participants in the pilot study scored above the cutoff for memory measures on the MMSE, while 30% scored above the cutoff on the cognitive screening test. The brief cognitive screening test provides reasonable sensitivity and specificity and includes a number of core components of mental functioning, noted the investigators.

The cognitive screening test was able to detect the measurable memory impairments demonstrated by the full neuropsychologic evaluation, according to the researchers. Furthermore, the test detected a higher degree of cognitive impairment than was found on the full neuropsychologic evaluation, they said.

How Effective Is the MMSE?

CLICK here to continue reading

and Click Here for Additional Information on This Topic

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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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Research Findings Suggest new cause, possible treatment for multiple sclerosis


Purdue University    - Nov 23, 2010

WEST LAFAYETTE, Ind. - Researchers have found evidence that an environmental pollutant may play an important role in causing multiple sclerosis and that a hypertension drug might be used to treat the disease.

The toxin acrolein was elevated by about 60 percent in the spinal cord tissues of mice with a disease similar to multiple sclerosis, said Riyi Shi, a medical doctor and a professor of neuroscience and biomedical engineering in Purdue University's Department of Basic Medical Sciences, School of Veterinary Medicine, Center for Paralysis Research and Weldon School of Biomedical Engineering.

The research results represent the first concrete laboratory evidence for a link between acrolein (pronounced a-KRO-le-an) and multiple sclerosis, he said.

"Only recently have researchers started to understand the details about what acrolein does to the human body," Shi said. "We are studying its effects on the central nervous system, both in trauma and degenerative diseases such as multiple sclerosis."

The compound is an environmental toxin found in air pollutants including tobacco smoke and auto exhaust. Acrolein also is produced within the body after nerve cells are damaged. Previous studies by this research team found that neuronal death caused by acrolein can be prevented by administering the drug hydralazine, an FDA-approved medication used to treat hypertension.
The new findings show that hydralazine also delays onset of multiple sclerosis in mice and reduces the severity of symptoms by neutralizing acrolein.


 IMAGE: This drawing depicts how the environmental pollutant acrolein may damage nerve insulation called myelin in multiple sclerosis. "A " represents the normal structure of nerve fibers and myelin; "B " represents how...
Click here for more information.

"The treatment did not cause any serious side effects in the mice," Shi said. "The dosage we used for hydralazine in animals is several times lower than the standard dosing for oral hydralazine in human pediatric patients. Therefore, considering the effectiveness of hydralazine at binding acrolein at such low concentrations, we expect that our study will lead to the development of new neuroprotective therapies for MS that could be rapidly translated into the clinic."


















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Keep Informed and up-to-date with information concerning
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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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Of the MS Symposium, a Recent message from an MS Patient in Miami

Stuart -- You are to be commended for hosting the best MS program that Bunny & I have attended.  All the speakers were knowledgeable & interesting.  I am program chair for the Rotary Club of Miami Dadeland-Pinecrest, which meets for breakfast every Monday, 7:30-8:30, at the Dadeland Marriott Hotel in Kendall.  If you ever have the desire to get up early & drive south, I would be happy to schedule you to present a program to the club next year.  You and "MS Views and News" are a treasure for South Florida & the MS community.
Ron Lieberman
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"Providing You with 'MS Views and News'is what we do"
Keep Informed and up-to-date with information concerning
 Multiple Sclerosis when registered at
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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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Novel compounds to promote remyelination in multiple sclerosis

ABSTRACT:

Multiple sclerosis (MS) is a chronic degenerative and debilitating disease of the central nervous system (CNS) characterized by inflammation and demyelination. Despite the improved relapse management provided by immune modulating treatments, progression of the handicap in MS patients remains because of progressive and irreversible axonal degeneration. 


Based on these observations, early neuroprotection and myelin repair strategies should be considered as additional therapeutic requirements for MS patients. Importantly, experimental evidence indicate that new myelin sheaths in MS lesions are formed by oligodendrocyte progenitor cells (OPC) present throughout the adult CNS or newly generated from adult stem cells present in the subventricular zone (SVZ). However this process may be limited because of insufficient OPC recruitment or impaired maturation process. Several growth factors have been shown to affect OPCs survival and proliferation such as platelet-derived growth factor (PDGF), neurotrophin-3 and glial growth factor-2 while insulin-like growth factor (IGF1) and T3 hormone promote their maturation. Mimicking action of theses growth factors with a drug is one of the challenges we addressed.

We previously identified a new class of cholesterol-oxime compounds for their neuroprotective activities. Among these compounds, olesoxime (TRO19622) has been shown to accelerate axon regeneration and remyelination in the peripheral nervous system after sciatic nerve crush




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"Providing You with 'MS Views and News'is what we do"
Keep Informed and up-to-date with information concerning
 Multiple Sclerosis when registered at
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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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Tuesday, November 23, 2010

An MS Patient's Story: Multiple Sclerosis Not to Stop 'Don' from Skydiving for his 80th birthday...

As we approach the last quarter of our lives, none will escape problems with health:  mental, physical or emotional.  We all face adversities.  It is how we deal with them that is what defines who we are.

I tell people with incurable diseases that the most important letters in their lives are T-R-Y.  If you don’t try, you will never know what you can accomplish.

“Bedridden” and there is a glass of water out of reach, you must try to get that glass!  If you get an inch closer daily, you might eventually get it.  But if you don’t try, the end game is… YOU GAVE UP!  Once you accept defeat, you are defeated and will never progress beyond that point.  There is no such thing as a good fight – only “FIGHT”. 

M.S. has limitations but you will never know those real limits unless you test them.
M.S. feeds on hopelessness and depression because these limitations become magnified.
Being alive does not mean you are living.
Attack each new day with a smile.  Don’t let your illness turn it into a frown.
Remember this philosophy pertains to all with incurable diseases.  So, spread the word.

On November 28, I will parachute (this is not a stunt) with five friends to give Multiple Sclerosis and all incurable diseases visibility, to prove that perceived limitations of age and illness must be tested, never accepted.

Also on November 28th  I will turn 80 years young.  Are you young enough to help?

Written By:         Donald R. Kaufman
Email Address:  drk2lhp@aol.com


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MS Views and News/Stuart Schlossman, wishes a Happy Birthday to 'Don' and good wishes for a successful jump...


Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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Advocacy information from The Consortium of MS Centers


AdvocacyPrintE-mail
The Advocacy page provides resources and tools to ensure that patients' needs and wishes are taken seriously
and their best interests are put first.  Advocates must be skilled go-betweens, educators, troubleshooters,
negotiators, and proactively vocal in tricky situations. In the role of patient advocate, the healthcare team
must walk a fine line between paternalism and interest protection.  Respecting patients as partners, and
promoting their perspective is an essential part of advocacy (Mitchell & Bournes, 2000).
  1. Advocacy in Multiple Sclerosis
    A White Paper prepared by CMSC
    Published: 2010
    (click here to view the pdf)
  2. Social Security Disability and MS: The Impact of the MS Listing
    Jamie R. Hall
    Posted: May 2010
    (click here to view the pdf)
  3. Social Security Disability: A PrimerJamie R. Hall
    (click here to view the pdf)
  4. What You Need To Know About Social Security Disability Insurance (SSDI)
    David Spero, RN
    Posted: April 2003
    (click here to view the pdf)
  5. The New Americans with Disabilities Act is Here!
    Peter Fischer
    Posted: September 2010



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"Providing You with 'MS Views and News'is what we do"
Keep Informed and up-to-date with information concerning
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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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