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Saturday, December 4, 2010

Environmental toxin acrolein may help cause multiple sclerosis


Researchers from Purdue University have discovered that an environmental toxin may aid in the cause of multiple sclerosis.
The study's lead researcher is Riyi Shi, a medical doctor and professor of neuroscience and biomedical engineering in Purdue University's Department of Basic Medical Sciences, School of Veterinary Medicine, Center for Paralysis Research and Weldon School of Biomedical Engineering. Shi and his team of researchers have found that a certain environmental toxin could be held partially responsible for causing multiple sclerosis (MS).
The toxin, acrolein, is found in air pollutants like auto exhaust and tobacco smoke. It is also created inside the body when nerve cells are damaged.
Nerve cells are insulated with myelin, and when a person has MS, the myelin is dismantled and the nerve fibers are damaged. Researchers believe acrolein is responsible for the dismantling of the myelin as well as inducing the creation of free radicals, which are compounds that cause further injury to tissues that are already damaged due to trauma or disease.
"Only recently have researchers started to understand the details about what acrolein does to the human body," said Shi. "We are studying its effects on the central nervous system, both in trauma and degenerative diseases such as multiple sclerosis."
To see if the researchers were correct about acrolein's effects, Shi and his team of researchers used a disease much like MS to elevate the acrolein in the spinal cord tissues of mice by nearly 60 percent.
To neutralize acrolein and temporarily halt the onset of MS, Shi used the drug hydralazine, which is an FDA-approved medication normally used to treat hypertension. Previous studies conducted by Shi and his team have shown that hydralazine prevents acrolein from causing neuronal death.
For this particular study, researchers concluded that a connection existed between acrolein and MS because the elevated acrolein levels within the mice were reduced by 50 percent when given hydralazine. According to Shi, this study is the first concrete laboratory evidence showing a link between acrolein and MS.
"The treatment did not cause any serious side effects in the mice," said Shi. "The dosage we used for hydralazine in animals is several times lower than the standard dosing for oral hydralazine in human pediatric patients. Therefore, considering the effectiveness of hydralazine at binding acrolein at such low concentrations, we expect that our study will lead to the development of new neuroprotective therapies for MS that could be rapidly translated into the clinic."
In addition, the researchers have also discovered the specific chemical signature of hydralazine, which could lead to synthetic alternatives with less side effects.
The abstract can be found here.
Article Source: MS Trust.org


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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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Four times as many women are deprived of vitamin D in the north-east of Scotland as in the south of England, according to a new study


22 November 2010 - BBC
Vitamin D, which helps the body absorb calcium, is created naturally in the body by exposure to the sun.
The study compared the amount of sunlight to which women were exposed.
In Aberdeen, 40% women had below minimum recommended amounts of the vitamin during the winter, compared to 10% in Surrey.
During the summer, 9% of women in the north-east of Scotland still lacked vitamin D.
Scientists from the universities of Aberdeen and Surrey compared sunlight exposure among 500 women in the two locations.
The participants, who were all between the ages of 55 and 70, were asked to wear a badge with a film that detected the amount of UVB rays to which they were exposed daily.
The study found those in Scotland received half as much sun as their southern counterparts and were "significantly" more deprived of UVB rays.
But in Scotland the sunshine is only strong enough to provide vitamin D between April and September, and Scots have been advised to top up their levels with a healthy diet.

'Strike the balance'

The researchers said the findings highlighted the need for better public advice on ways to boost vitamin D levels during the winter months.
Low levels can lead to rickets - a rare disease that causes the softening and weakening of bones in children - and has been linked to multiple sclerosis.
Dr Helen Macdonald, from the University of Aberdeen's Institute of Medical Sciences, said: "We cannot assume that winter requirements of vitamin D are met by the stores accumulated over summer if people do not get enough sunlight to make sufficient vitamin D.
"Dietary sources of vitamin D are important but the vitamin D status in the current diet of women in the UK is unlikely to be adequate.
"We need to look at appropriate guidelines regarding safe sunlight exposure, to strike the balance between ensuring adequate protection from the sun and obtaining vitamin D from UVB rays."
Last year, schoolboy Ryan McLaughlin took a petition to the Scottish Parliament which called on ministers to produce new guidelines on vitamin D supplements for children and pregnant women, along with an awareness campaign about the issue.
Ryan, whose mother Kirsten has been diagnosed with MS, had has some success in his campaign, with the Scottish government issuing leaflets in September advising people how to avoid vitamin D deficiency.
The latest study has been published in the Osteoporosis International journal.
Article Source: MS Trust.org


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Friday, December 3, 2010

Searching for articles and information on CCSVI, MS Pain and other topics relating to Multiple Sclerosis


Use the search box, found on this blog:  http://wwwmsviewsandrelatednews.blogspot.com - to enter a keyword of anything to do with Multiple Sclerosis.

The Search Box is found on the right side of the page, just above the 'MS Views and News' logo.

Mostly all that is known of multiple sclerosis, can be found in this blog and then cross references you to the source for the information.

USE "Stu's Views and MS News" as Your source for ms information...

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Multiple Sclerosis Study Uncovers Early Impact Of Gilenya

TreatmentTrends®, Multiple Sclerosis Study Uncovers Early Impact Of Gilenya On Perceptions And Anticipated Use Of Products Within The MS Market
December 2nd, 2010

BioTrends recently published TreatmentTrends®: Multiple Sclerosis, a syndicated biannual report that provides a comprehensive view of the current and expected future management ofmultiple sclerosis (MS) based on primary research fielded with 103 neurologists in the U.S. A parallel report covering the European market (EU5) will be published later this month. These reports cover the use of disease-modifying agents (DMAs) for the treatment of MS, as well as attitudes and perceptions toward these products, advantages and disadvantages, ideal patient types, barriers to growth, and expected future use. In addition, respondents were queried about their awareness of and interest in MS-related DMA and symptomatic products in development.



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Keep Informed and up-to-date with information concerning
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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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Wednesday, December 1, 2010

Potential Treatment for Progressive Multifocal Leukoencephalopathy (PML)

Received from Gerson G in South Florida
November 30, 2010

Cytheris Announces Publication of Clinical Case Study Combining Recombinant Human Interleukin-7 (CYT107) with Antiviral Agent CMX001 as Potential Treatment for Progressive Multifocal Leukoencephalopathy (PML)

Combination Therapy with Two Investigational Agents, Cytheris’ CYT107 and Chimerix’s CMX001, Indicates Potential for Clearing the JC Virus that Causes PML, a Rare and Usually Fatal Neurological Disease

PARIS---Cytheris SA, a clinical-stage biopharmaceutical company focused on research and development of new therapies for immune modulation, today announced the publication of a case study report based on successful treatment of Progressive Multifocal Leukoencephalopathy (PML) with combination therapy consisting of two investigational agents, Cytheris’ recombinant human interleukin-7 (CYT107) and CMX001, an investigational, oral broad-spectrum antiviral drug (Chimerix, Research Triangle Park, NC) in the Journal of Antimicrobial Chemotherapy. The combination therapy succeeded in eradicating the polyomavirus JC, the virus that causes PML, in less than two weeks following initiation of CYT107 treatment, and four weeks following the introduction of CMX001.

Progressive Multifocal Leukoencephalopathy (PML) is a rare and usually fatal neurological disease caused by the polyomavirus JC. The virus, first identified in 1971, multiplies in and destroys oligodendrocytes, which are cells of the brain that produce the myelin sheath surrounding neurons. Symptoms include loss of vision, impaired speech, paralysis, cognitive decline and weakness. There is no known cure for PML.

CONTINUE READING from Businesswire


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NPR NEWS: Panel Clarifies Advice On Vitamin D Intake


Before reading, please remember that all people are different and that for those of us that ARE Vitamin D deficient, we need to speak with our own doctors  before taking in other recommendations

November 30, 2010
A government-organized panel of doctors goes against recent advice to increase vitamin D intake. Their new study says most Americans get plenty of vitamin D in their regular routine and diet — and supplements can even be harmful. NPR's Guy Raz talks with one of the doctors on the panel that released the report — bone specialist Clifford Rosen.
Copyright © 2010 National Public Radio®. For personal, noncommercial use only. See Terms of Use. For other uses, prior permission required.
ROBERT SIEGEL, host:
There's new guidance today from the Institute of Medicine on the use of a popular nutritional supplement: Vitamin D. Vitamin D has been flying off the shelves in the past several years thanks to doctors' warnings that we are all Vitamin D deficient. Well, now comes news that we are consuming too much Vitamin D and too much calcium in supplements.
GUY RAZ, host:
If it all sounds confusing to you, it was also a surprising conclusion for Dr. Clifford Rosen. He was on an independent panel of medical researchers that determined the Vitamin D craze has gone a bit too far. And he's with us in the studio now.
Dr. Rosen, first of all, it has practically an article of faith that most Americans don't have high enough Vitamin D levels in their blood. That's not true, you say?
Dr. CLIFFORD ROSEN (Maine Medical Center Research Institute): We don't think that's true. That certainly was an article of faith, and many of us believed it. I certainly did coming into the Institute of Medicine committee.
I published studies showing low Vitamin D in Maine women, particularly during the winter months. So I was relatively convinced and was supporting Vitamin D supplementation.
RAZ: Now, some doctors recommend an average of 1,000, up to 3,000 units per day. Your panel recommends 600 units per day per adult. How did you come to that conclusion?
Dr. ROSEN: Well, we looked at what the dietary intake and this was both Canada and the United States. So this was a joint effort.


CONTINUE READING or LISTEN to this story, by clicking here


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Tuesday, November 30, 2010

Maintaining an active lifestyle essential for people living with MS

November 30, 2010

Multiple Sclerosis is "the single biggest disabler of young, healthy adults," says Edmonton neurologist and University of Alberta associate clinical professor Dr. Brad Stewart. "Medication can cut down on relapses. Some drugs will cut down on disability. Some will have an impact on quality of life."

But Stewart, like many experts, says exercise also plays a crucial role in improving life for people with MS.

"Exercise improves the fatigue level, probably better than any drug out there," Stewart says. "Tai chi and yoga, for instance, have a markedly positive impact on patients' balance and on improving their level of fatigue."

"Exercise is good for all of us and is specifically good for MS patients," says neurologist Dr. Virender Bhan, an associate professor and director of the MS research unit at Dalhousie University, who has cared for MS patients for two decades.

"We recommend that our patients should be as active as possible, keeping in mind that they need to be safe, whatever the activity," says Trudy Campbell, one of only three nurse practitioners in Canada specializing in working with multiple sclerosis patients.

"Exercise, learning strategies to cope with stress, adequate nutrition, maintaining an ideal body weight and family support all play a role in living with MS," she says.

As part of her research projects, Memorial University postdoctoral fellow and physiotherapist Michelle Ploughman worked with numerous older individuals who have had MS for more than 20 years. "They talked about what they have done to manage their condition and their quality of life now," she says. "I met people in their seventies and eighties who were still contributing to their community, providing telephone support to others with MS and remaining as active as possible. Their lives were not always rosy, but certainly the people who were doing best followed the trend of resilience, taking charge and staying active."



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Sunday, November 28, 2010

"Here I Am and This is What I Think of CCSVI" - An 'MS' (Multiple Sclerosis) Patient's Story

Written by: Marcel Gignac - Published November 28, 2010

Wow.. it is hard to believe that a week ago today I celebrating by eating steak and lobster in New York State. Of course the reason for celebrating was the fact that I was actually eating the steak and lobster and not trying to force another Ensure into me. For me, drinking an Ensure is no different than trying to gag down that glow-in-the-dark shit they give you for x-rays.

So how does it happen? How does one go from the hobbling dead to eating steak and lobster?


I am still trying to figure that out. It never could have happened without the help of amazing friends, family and even strangers that I will never know nor be able to repay. My family and I can never thank them enough. But just to say I had help and leave it as that is the ultimate in understatements. My trying to stay alive was a logistical nightmare that I would never have survived on my own. My problems were never just about trying to raise funds.

So, before we go any further... 1 year ago I wrote that CCSVI was not a cure but was a key. I stand by that.



CLICK HERE to continue reading Marcel's story



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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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