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Friday, August 12, 2011

Encouraging Data on Daclizumab


Biogen Idec (BIIB - Analyst Report) and Abbott Labs (ABT -Analyst Report) recently presented positive top-line data on their multiple sclerosis candidate, daclizumab. Biogen and Abbott Labs presented data from a phase IIb study – SELECT.


The global, randomized, double-blind, placebo-controlled, one-year, dose-ranging study was conducted to evaluate the safety and efficacy of daclizumab in 600 patients with relapsing-remitting multiple sclerosis (RRMS).


Two doses (150 mg or 300 mg every four weeks) of daclizumab were evaluated. Results showed that daclizumab reduced the annualized relapse rate by 54% in the 150 mg dose and 50% in the 300 mg dose arm compared to placebo.


Key secondary endpoints were also achieved by the candidate. The study also investigated daclizumab’s effect on disability progression as measured by the expanded disability status scale (EDSS) as a tertiary endpoint. Results showed that daclizumab reduced the risk of sustained disability progression at one year by 57% and 43% in the 150 mg and 300 mg dose arms, respectively. Biogen and Abbott Labs are currently analyzing the data further and expect to present detailed results at an upcoming medical meeting


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