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Disclaimer: 'MS Views and News' DOES NOT endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.

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Wednesday, September 28, 2011

ACTH for Multiple Sclerosis is gaining popularity

Questcor, the maker of ACTH said it now estimates that new, paid prescriptions of Acthar for the treatment of certain symptoms of multiple sclerosis rose 160% over those in the third quarter last year to about 850. In addition, Questcor shipped 2,750 vials of Acthar, which also is used to treat other conditions, up 45% from last year's quarter.



Acthar (repository corticotropin injection) is natural source ACTH (adrenocorticotropic hormone) in 16% gelatin to provide a prolonged release after intramuscular or subcutaneous injection.
Acthar is currently approved in the U.S. for the treatment of acute exacerbations of multiple sclerosis in adults, and as monotherapy for the treatment of infantile spasms in infants and children under 2 years of age. It is also indicated to induce a diuresis or a remission of proteinuria in the nephrotic syndrome without uremia of the idiopathic type or that due to lupus erythematosus, as well as indicated for the treatment of several other diseases and disorders. For a full list of approved indications, please see the Acthar prescribing information.


Questcor is dedicated to supporting patients at each step of the treatment process. With this in mind, Questcor personnel created the Acthar Support and Access Program (A.S.A.P.).

The Acthar Support & Access Program (A.S.A.P.) does the following:

  • Contacts the patient's insurance company
  • Investigates benefits and facilitates any prior authorizations if necessary
  • Routes the prescription to the appropriate specialty pharmacy for fulfillment
  • Ships Acthar and the necessary supplies next day for overnight delivery to the patient's home or alternate location under the appropriate temperature-controlled conditions


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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.

Scientists Find a way to rapidly produce functional cells that restore myelin

Sept 26, 2011



Process paves way for research, possible treatments of multiple sclerosis and more

Scientists at Case Western Reserve University School of Medicine found a way to rapidly produce pure populations of cells that grow into the protective myelin coating on nerves in mice. Their process opens a door to research and potential treatments formultiple sclerosiscerebral palsy and other demyelinating diseases afflicting millions of people worldwide.


The findings will be published in the online issue of Nature Methods, Sunday, Sept. 25, at 1 p.m. EST.
"The mouse cells that we utilized, which are pluripotent epiblast stem cells, can make any cell type in body," Paul Tesar, an assistant professor of genetics at Case Western Reserve and senior author of the study, explained. "So our goal was to devise precise methods to specifically turn them into pure populations of myelinating cells, called oligodendrocyte progenitor cells, or OPCs."
Their success holds promise for basic research and beyond.


"The ability of these methods to produce functional cells that restore myelin in diseased mice provides a solid framework for the ability to produce analogous human cells for use in the clinic," said Robert H. Miller, vice dean for research at the school of medicine and an author of the paper.
Tesar worked with CWRU School of Medicine researchers Fadi J. Najm, Shreya Nayak, and Peter C. Scacheri, from the department of genetics; Anita Zaremba, Andrew V. Caprariello and Miller, from the department of neurosciences; and with Eric. C. Freundt, now at the University of Tampa.
Myelin protects nerve axons and provides insulation needed for signals to pass along nerves intact. Loss of the coating results in damage to nerves and diminished signal-carrying capacity, which can be expressed outwardly in symptoms such as loss of coordination and cognitive function.


Scientists believe that manipulating a patient's own OPCs or transplanting OPCs could be a way to restore myelin.


And, they have long known that pluripotent stem cells have the potential to differentiate into OPCs. But, efforts to push stem cells in that direction have resulted in a mix of cell types, unsuitable for studying the developmental process that producesmyelin, or to be used in therapies.



READ MORE


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On the 4th Wednesday of each month  
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"MS Views and News" is a 501©(3) Not-for-Profit organization as recognized by the Internal Revenue Service 
.. All contributions are tax deductible to the fullest extent allowed by law 
.===========================================================
Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.

Monday, September 26, 2011

Clinical Successes and New Technologies Revive Gene Therapy


With some of the safety kinks worked out, gene-based treatments are making more progress.

Clinical Successes and New Technologies Revive Gene Therapy
Effective gene delivery includes direct DNA delivery, genetically engineered autologous cells, and specifically targeted gene modification or insertion. [© Gernot Krautberger - Fotolia.com]


The prospect of curing human diseases by replacing a disease-related gene with a normal version remains the ultimate goal of gene therapy. But in its early days, attempts at gene therapy met with unpredictable and occasionally fatal outcomes. The field sustained a serious setback in 2000 following the death of 18-year old Jesse Gelsinger after receiving gene therapy to treat orinthine trascarbamlase deficiency (OTCD), a rare metabolic disorder that prevents the body from breaking down ammonia.
Gene therapy took another blow in September 2003, when the FDA placed a temporary halt on all gene therapy trials using retroviral vectors in blood stem cells. The agency was responding to the development of a leukemia-like disorder that developed in a three-year-old boy following successful gene therapy for to X-linked severe combined immunodeficiency disease (X-SCID). Subsequently, the disease developed in three children, one of whom died from it.
Now, bolstered by the development of enabling technologies and recent clinical successes, gene therapy is making a significant comeback. Effective gene delivery has been established in multiple formats including direct DNA delivery, genetically engineered autologous cells, and specifically targeted gene modification or insertion.


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"MS Views and News" is a 501©(3) Not-for-Profit organization as recognized by the Internal Revenue Service 
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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.

For people with MS, exercise can be very beneficial to overall health and may even help ease symptoms.


Information found here was provided by Barbara S., in Delray Beach
Regular exercise is a good idea for anyone. But for the approximately 400,000 Americans living with multiple sclerosis, there are even more specific benefits.
Actually, doctors used to recommend that people living with MS avoid exercise entirely due to fear of aggravating symptoms. But now there is a great deal of evidence to suggest that regular exercise not only improves quality of life for people with multiple sclerosis, but that it may also help ease symptoms and minimizethe risk of certain complications down the road.
Tanuja Chitnis, MD, assistant professor of neurology and director of the Partners Pediatric MS Center at Massachusetts General Hospital for Children, says that making exercise "part of a healthy lifestyle, with two or three sessions per week" is a good idea for most people living with MS. And, she adds, specific exercises can help people address particular mobility issues. She recommends seeking out the help of a physical therapist to help determine which exercises would be most beneficial for you.
Before starting any MS exercise program, however, be sure to consult your doctor about what type of regimen is best for you.
The Benefits of Exercise for MS Patients
Getting active can help relieve a number of symptoms and complications that are commonly associated with MS. These include:
Fatigue
Being extra tired is a common complaint among people with multiple sclerosis. Exercise, including yoga, can help combat this. A recent study examined the fatigue levels ,,, 
Continue reading by clicking here
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On the 4th Wednesday of each month  
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"MS Views and News" is a 501©(3) Not-for-Profit organization as recognized by the Internal Revenue Service 
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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.