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Disclaimer: 'MS Views and News' DOES NOT endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.

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Friday, December 2, 2011

Risk factors for CCSVI found to be similar to those for developing MS


By ELLEN GOLDBAUM
Published: December 1, 2011
The first study to investigate risk factors for the vascular condition called CCSVI (chronic cerebrospinal venous insufficiency) in volunteers without neurological disease has identified what the researchers call a remarkable similarity between this condition and possible or confirmed risk factors for multiple sclerosis (MS).
The UB study investigated associations between CCSVI and demographic, clinical and environmental risk factors in a large control group of volunteers who did not have known central nervous system disease.
“Our results suggest that risk factors for CCSVI in this group of volunteers are remarkably similar to those of possible or confirmed importance to MS, but we do not yet understand the whole story,” says Robert Zivadinov, professor of neurology in the UB School of Medicine and Biomedical Sciences, and senior author on the study.
Published on Nov. 30  in PLoS One, the current study of 252 volunteers “was designed to help provide scientists and the MS patient community with new information that, combined with the results of studies that are still ongoing at UB, will ultimately help explain CCSVI and its relationship to MS,” according to Kresimir Dolic, lead author on the study. Dolic, a radiologist from the Department of Radiology, University Hospital, Split, Croatia, was a visiting fellow at the Buffalo Neuroimaging Analysis Center, part of UB’s Department of Neurology, where the study was conducted.
CCSVI refers to impaired blood flow from the central nervous system to the periphery. It has been hypothesized that this narrowing of veins restricts blood flow from the brain, altering brain drainage, and  may contribute to brain tissue injury that is associated with MS.

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Thursday, December 1, 2011

Caffeine, Headaches and Multiple Sclerosis

Stuart Says: and GOLLY - do I know about Headaches.. I am so glad to have found this:


By Julie Stachowiak, Ph.D., About.com Guide   November 30, 2011



About a week and a half ago, I eliminated caffeine from my world. That's right, I stopped drinking my beloved coffee.


I took such a drastic step because I have been getting migraine headaches - sometimes full-blown, grit-your-teeth-in-pain ones, and other times, just really uncomfortable ones. All of these headaches were combined with nausea and many of them also came with sensitivity to light. People with multiple sclerosis are much more prone to migraines and headaches in general, than the rest of the population, but they are usually treated the same way. I have tried migraine meds before. While they did work, they knocked me out or made me feel "off."


I also knew that these headaches were directly related to something I was eating or drinking. I would be fine until I ate something or drank anything besides water. About 75% of the time, as soon as I consumed something, I would have a major headache. I made an appointment with an allergist, who told me that my symptoms were not those of an allergy and that he couldn't help me (besides telling me not to eat things that seemed to bother me).


One night, I decided to do a little digging around and found the book by David Buchholz, Heal Your Headache: The 1-2-3 Program for Taking Charge of Your Pain. Sure enough, Dr. Buchholz, a Johns Hopkins physician, says that many migraines are caused by food triggers. He presents a diet plan to follow that eliminates all triggers for 4 months (then you can add them back in if they don't bother you). Caffeine is number one on his list of triggers and he does say that people with migraines should NEVER add caffeine back to their diet.



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Novartis MS Pill Gilenya Rejected by U.K. Health-Cost Agency *** RIDICULOUS***


By Makiko Kitamura
Dec. 1 (Bloomberg) -- Novartis AG’s multiple sclerosis pill Gilenya failed for a second time to gain the backing of the U.K.’s health-cost agency, denting the company’s ambitions to turn the drug into a multibillion-dollar-a-year blockbuster.
Novartis failed to show that Gilenya would be cost effective compared with existing options available even after the drugmaker proposed a discount, the National Institute for Health and Clinical Excellence said in a statement today. NICE said in August the annual cost for the medicine, also known as fingolimod, was about 19,196 pounds ($30,134).
Gilenya, approved in Europe in March as the first oral treatment for MS, is among the products that Basel, Switzerland- based Novartis is counting on to fuel sales growth as patents start to expire on the company’s best-selling treatments, including the hypertension pill Diovan.
“While Novartis submitted evidence that shows fingolimod can reduce relapses, our independent committee has not been convinced that it is a cost effective treatment option,” Andrew Dillon, chief executive of NICE, said in the statement.
NICE advises the state-run National Health Service on which medicines represent value for money as the U.K. government works to save as much as 20 billion pounds a year on medical expenses.

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No Cerebral or Cervical Venous Insufficiency in US Veterans With Multiple Sclerosis

Information provided from Mike B., in Az



Source

Medical Service (Drs Marder and Stüve), and Radiology Division (Dr Gupta), VA North Texas Health Care System, and Department of Neurology, University of Texas Southwestern Medical Center at Dallas (Drs Marder, Greenberg, Frohman, and Stüve), Dallas; and Baton Rouge Neurology Associates, Baton Rouge General Medical Center, Baton Rouge (Dr Awad), and Department of Neurology, Ochsner Clinic Foundation, New Orleans (Dr Bagert), Louisiana.

Abstract

OBJECTIVE:

To determine if chronic cerebral venous insufficiency exists in patients with multiple sclerosis (MS) using ultrasonography and 4-dimensional color Doppler ultrasonography examination and unverified criteria proposed by Zamboni et al.

DESIGN:

Patients with MS and clinically isolated syndrome were matched by age and sex with subjects with migraine or no neurological disease. All subjects underwent gray-scale, color, and spectral Doppler ultrasonography examination of the internal jugular veins (IJVs), vertebral veins, and deep cerebral veins for stenosis, absence of signal, and reflux.

SETTING:

Academic MS center. Patients  All patients with MS fulfilled revised McDonald criteria for the diagnosis of MS. Patients with clinically isolated syndrome exhibited a typical transient focal neurological deficit and had magnetic resonance imaging lesions typical of MS. Control subjects were recruited from the VA migraine clinic or staff.

MAIN OUTCOME MEASURES:

Five parameters of venous outflow used by Zamboni et al were examined: (1) IJV or vertebral vein reflux, (2) deep cerebral vein reflux, (3) IJV stenosis, (4) absence of flow in IJVs or vertebral veins, and (5) change in cross-sectional area of the IJV with postural change.

RESULTS:

There was no significant difference in the number and type of venous outflow abnormalities in patients with MS compared with controls.

CONCLUSION:

This study does not support the theory that chronic cerebral venous insufficiency exists in MS.

PMID:
 
21825217
 
[PubMed - as supplied by publisher]



..



ON DECEMBER 14th, 2011


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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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Wednesday, November 30, 2011

AANN, ARN, and IOMSN Release Nursing Management of the Patient with Multiple Sclerosis in the Clinical Practice Guideline Series


Released: 11/30/2011 9:00 AM EST
Source: Association of Rehabilitation Nurses
Newswise — Glenview, IL— November 2011 —The American Association of Neuroscience Nurses (AANN), the Association for Rehabilitation Nurses (ARN) and the International Organization of Multiple Sclerosis Nurses (IOMSN) are proud to announce the newest addition to the respected AANN Clinical Practice Guideline series, Nursing Management of the Patient with Multiple Sclerosis. The publication was supported by an educational grant from TEVA Neuroscience.
Nursing care of patients with MS and their families or care partners has evolved from a focus on interventions during periods of crisis to a focus on symptom management, wellness, prevention of disease worsening, and empowerment. The goal of this guideline is to offer evidence-based recommendations on nursing activities that have the potential to maximize outcomes for adults with MS.
This guideline is the second collaborative publication in the AANN Clinical Practice Guideline series, which has produced more than ten guidelines to date. The publication promotes evidence-based practice across the continuum of care. A team of 26 nurse volunteers from AANN, ARN, and IOMSN developed, authored, and reviewed the content offered in the document.



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Tuesday, November 29, 2011

Canadian Researchers to study role of inflammation in MS


Date: Tuesday Nov. 29, 2011 9:24 AM ET
TORONTO — A group of Canadian researchers has received funding to try to figure out what role inflammation plays in progressive multiple sclerosis.


New research, led by Dr. Peter Stys from the University of Calgary's Hotchkiss Brain Institute, is going to look at damage that occurs in MS prior to inflammation.


The work, being done in collaboration with scientists at several other institutions, is being funded by the Multiple Sclerosis Society of Canada and the Multiple Sclerosis Scientific Research Foundation.


The society and foundation have awarded a $3.8-million grant to the researchers looking at this issue.
To date science has attributed the damage done in the disease to autoimmune attacks, but this research team wants to see whether the inflammation process is triggered by an underlying degenerative process.


About 10 per cent of people with MS are diagnosed with the primary progressive form of the disease.


Secondary progressive MS is more common; it begins as relapsing remitting MS, but within 10 years half of the people diagnosed with relapsing MS go on to develop secondary progressive.


There are seven licensed disease modifying treatments for relapsing MS in Canada, but little progress has been made in managing primary progressive MS or secondary progressive MS without relapses.


"We urgently need research that tackles the challenges unique to the progressive forms of MS," says Karen Lee, vice-president of research, MS Society of Canada.


Read more: http://www.ctv.ca/CTVNews/Health/20111129/multiple-sclerosis-inflammation-111129/#ixzz1f9P8IwPg





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Disclaimer:  'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
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