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Disclaimer: 'MS Views and News' DOES NOT endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.

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Friday, January 27, 2012

Phase 3b Trial Evaluates Tysabri as MS Treatment for Secondary Progressive MS (SPMS)





Biogen Idec and Elan Corporation announced a global Phase 3b study that is being conducted to evaluate the effectiveness of Tysabri as a treatment for secondary-progressive multiple sclerosis (SPMS).

The Ascend study is part of an ongoing commitment of both Biogen Idec and Elan to find ways to improve the well-being of patients with multiple sclerosis. Ascend (A Study to Characterize the Efficacy of Natalizumab on Disability in SPMS) is a double-blind, placebo-controlled study with SPMS patients being randomized to receive either Tysabri 300 mg or placebo intravenously every four weeks for 96 weeks. A global study, Ascend is expected to enroll approximately 850 patients in 15 countries.

Study participants will be between the ages of 18 and 58, with a diagnosis of SPMS for at least two years; an Expanded Disability Status Scale (EDSS) score between 3.0 and 6.5, MS Severity Score of four or higher; documented, confirmed evidence of disease progression, independent of clinical relapses during the one-year prior to enrollment; and naïve to Tysabri treatment.

“The Ascend trial is investigating whether treatment with Tysabri may prevent worsening in walking, hand movement and daily functioning in these patients,” explains Aaron Miller, MD, member of the Ascend advisory board.

"One hypothesis behind the development of SPMS is that disease progression is a result of chronic inflammation in the brain tissue trapped behind the blood-brain-barrier. This causes destruction of the myelin sheath, which protects the coating around nerve fibers, as well as the progressive loss of nerve cells, which can lead to disability in MS patients,” says Richard Reynolds, professor of Cellular Neuroscience, Imperial College, London. “Preliminary data suggest that Tysabri may hinder this inflammation in the brain and reduce SPMS-related disease progression; therefore, further investigation of this hypothesis is warranted."

Release Date: Jan. 26, 2012
Source: Biogen Idec 
via DDmag




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Wednesday, January 25, 2012

Nutrition for the Brain and Nervous System



Multiple sclerosis (MS) is a chronic, degenerative disease of the nerves in your brain and spinal column, caused through a demyelization process.
Myelin is the insulating, waxy substance around the nerves in your central nervous system.
When the myelin is damaged by an autoimmune disease or self-destructive process in your body, the function of those nerves deteriorate over time, resulting in a number of symptoms, including:
  • Muscle weakness
  • Imbalance, or loss of coordination
  • Astigmatism and vision loss
  • Tremors
MS may progress steadily, or acute attacks may be followed by a temporary remission of symptoms.
In the video above, Dr. Terry Wahls tells the inspiring story of how she reversed multiple sclerosis after seven years of deterioration on the best conventional treatments available — simply by changing her diet!
Nutrition for Your Brain and Central Nervous System
Through her research into MS, Dr. Wahls discovered that, for some unknown reason, in addition to the commonly known symptoms, MS patients’ brains also tend to shrink. This roused her curiosity, and led her to research other diseases that have similar brain shrinkage, namely Huntington’s, Parkinson’s and Alzheimer’s Disease. One common denominator is poorly functioning mitochondria. Mitochondria are like little ‘batteries’ in your cells that manage the energy supply to the cell, and unless you consume the correct nutrients, eventual mitochondrial malfunction is the obvious result.
She discovered that three nutrients in particular are essential for proper mitochondrial function:
1. Animal-based omega-3 fat
2. Creatine
3. Coenzyme Q10 (CoQ10) or better yet the reduced version known as Ubiquinol.

Read more: http://www.care2.com/greenliving/dietary-tips-for-treating-multiple-sclerosis.html#ixzz1kV5qVU3p


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MS industry insiders are candid in predicting significant changes and growth as novel therapies enter the market


PRESS RELEASE - Jan. 24, 2012, 8:10 a.m. EST
Industry Insiders Predict Significant Changes in Multiple SclerosisAccording to a new report from Intellent, MS industry insiders are candid in  predicting significant changes and growth as novel therapies enter the
market and prices of current therapies are reduced

CHICAGO, Jan. 24, 2012 /PRNewswire via COMTEX/ -- In a new report detailing the Multiple Sclerosis landscape, industry insiders are candid in revealing specific areas of the market where more efficacious current therapies with better safety profiles are in demand. Due to the high cost of current therapies and the invasive nature of interferons, there are many unmet needs in the space. The growth of the market in the next few years is likely to increase exponentially.
The new report examines the current opinions of experts in the field concerning MS treatment options, while also reviewing potential drug treatments in Phase III clinical trials. Combining key opinion leader (KOL) input with a drug development pipeline (including key market drivers and challenges), this report provides readers with a comprehensive view of the MS therapeutic landscape.
The new report features extensive research collected first hand, with transcripts from interviews with industry thought leaders. According to several in the field, there are multiple opportunities for growth in the space as new treatments are developed: "This is an exciting time to be treating patients with multiple sclerosis; exciting in the sense that we have an increasing number of drugs. And it seems like we will probably have at least one a year for the foreseeable future..."

Continue reading

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Merck KGaA Gets EC Approval For Rebif Use Extension For Early Multiple Sclerosis



1/25/2012 2:57 AM ET
(RTTNews) - Merck KGaA (MKGAY.PK: News) said the European Commission or EC has approved extension of the indication of Rebif, a treatment for relapsing forms of multiple sclerosis or MS. This EC approval, based on REFLEX study results, is for the use of Rebif 44 micrograms three times weekly in patients who have experienced a single demyelinating event, an early sign of the disease, and who are at high risk of converting to MS.

Annalisa Jenkins, Head of Global Drug Development and Medical at the Merck Serono division. "Multiple sclerosis has an initial stage when clinical manifestations are not pronounced but irreversible neurological damage is taking place. Throughout the European Union, neurologists will now be able to prescribe Rebif for patients with early signs of this devastating disease."

The new labelling for Rebif is valid immediately in all 27 member states of the European Union. The company still invests in discovering and developing treatment options in this area, including active life-cycle management initiatives for Merck's foundation therapy, Rebif, as well as strengthening its existing and establish new collaborations to advance research and bring innovative solutions to patients living with MS.

CONTINUE Reading



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Monday, January 23, 2012

Synthetic Cannabis prescription drug (Sativex(R)) looks for FDA OK



Story Image
In this undated photo provided by GW Pharmaceuticals, a sample of the drug Sativex is shown. Sativex contains marijuana’s two best known components_delta 9-THC and cannabidiol_and already has been approved in Canada, New Zealand and eight European countries for relieving muscle spasms associated with multiple sclerosis. (AP Photo/ GW Pharmaceuticals)
Updated: January 22, 2012 7:33PM
 

SAN FRANCISCO — A quarter-century after the U.S. Food and Drug Administration approved the first prescription drugs based on the main psychoactive ingredient in marijuana, additional medicines derived from or inspired by the cannabis plant itself could soon be making their way to pharmacy shelves, according to drug companies, small biotech firms and university scientists.
A British company, GW Pharma, is in advanced clinical trials for the world’s first pharmaceutical developed from raw marijuana instead of synthetic equivalents— a mouth spray it hopes to market in the U.S. as a treatment for cancer pain. And it hopes to see FDA approval by the end of 2013.
Sativex contains marijuana’s two best known components — delta 9-THC and cannabidiol — and already has been approved in Canada, New Zealand and eight European countries for a different usage, relieving muscle spasms associated with multiple sclerosis.
FDA approval would represent an important milestone in the nation’s often uneasy relationship with marijuana, which 16 states and the District of Columbia already allow residents to use legally with doctors’ recommendations. The U.S. Drug Enforcement Administration categorizes pot as a dangerous drug with no medical value, but the availability of a chemically similar prescription drug could increase pressure on the federal government to revisit its position and encourage other drug companies to follow in GW Pharma’s footsteps.
“There is a real disconnect between what the public seems to be demanding and what the states have pushed for and what the market is providing,” said Aron Lichtman, a Virginia Commonwealth University pharmacology professor and president of the International Cannabinoid Research Society. “It seems to me a company with a great deal of vision would say, ‘If there is this demand and need, we could develop a drug that will help people and we will make a lot of money.’”

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NextGen Sciences Launches its 82 Protein Cerebrospinal Fluid (CSF) CNS Disease Biomarker Assay



London, UK and Ann Arbor, Michigan, US (PRWEB) January 2012

NextGen Group plc (AIM:NGG) is pleased to announce that its US-subsidiary NextGen Sciences Inc, a leader in biomarker discovery, measurement and qualification, has launched an expanded cerebrospinal fluid (CSF) multiple protein (multiplex) assay, csfdiscovery82, for central nervous system (CNS) biomarker discovery and qualification


The new assay simultaneously measures 82 human CSF proteins that are thought to have potential as biomarkers in CNS diseases, particularlyAlzheimer'sParkinson'smultiple sclerosis and ALS diseases. 


The launch of csfdiscovery82 demonstrates the acceleration in NextGen Sciences strategy of becoming a leading player in the growing CNS biomarker market.

Read more: Click Here




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