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Saturday, August 11, 2012
Thursday, August 9, 2012
Wednesday, August 8, 2012
Researchers have discovered that one or more substances produced by a certain type of immune cell may be involved in the progression of multiple sclerosis (MS), an autoimmune disease affecting the brain and spinal cord, may be involved caused by. The finding might lead to new, targeted treatments for those suffering from MS.
Leading researcher, Robert Lisak, M.D., a professor of neurology at Wayne State explained that B cells belong to a subset of circulating white blood cells (lymphocytes), which become immunoglobulin (antibodies) producing plasma cells when mature. However, B cells also seem to play a role in controlling other lymphocytes, particularly T cells, and help to regulate a healthy immune system.
The B cells attack the brain and spinal cord in patients with MS, which could be due to the fact that the nervous system and the meninges, the covering of the brain and spinal cord, produce substances that attract the B cells. Once within the meninges or central nervous system, the activated B cells secrete one or several substances that damage oligodendrocytes, i.e. cells that produce myelin, a protective substance, yet which do not seem to affect the immunoglobulins. The scientists observed that B cells seem to be more active in MS patients. This may explain whey these cells produce toxic substances and partially why they are attracted by the nervous system and the meninges.
Most of the brain is split into gray areas that contain neurons, and white areas, where neurons send their axons just like electrical cables carry messages, in order to communicate with other neurons and transfer messages from the brain to the muscles. The white parts of the brain have their particular color because the oligodendrocytes produce myelin, the axons' coating/insulation similar to that to the plastic coating of electrical cables, which is rich in cholesterol. Myelin accelerates communication along the axons, making it more reliable, yet when this coating degrades or is attacked, it can lead to 'leakages' or messages being sent to the wrong receptor during communication from the brain to other body parts. The team noted that oligodendrocytes also appear to play a role in other activities, which are vital for the nerve cells and their axons.
Londonderry, New Hampshire (PRWEB) August 07, 2012
Sharon had told the media she was quitting her gig on "America's Got Talent" because NBC had "discriminated" against Jack Osbourne by dropping him from an upcoming reality show called, "Stars Earn Stripes" ... in which celebrities compete in various military-style physical challenges.
And to make matters worse, Sharon had claimed Jack was notified by e-mail ... just two days before production was set to begin.
But NBC claims Sharon is blowing the whole thing out of of proportion -- but admits the network decided to NOT ask Jack to participate as a contestant after going through vigorous medical screening.
I recently watched an interview with Meredith Vieira and her husband,Richard Cohen,an Emmy and Peabody-award winning former television producer,journalist and reporter who has had MS since 1973,when,at that time,the standard practice of "diagnose and adios"was all that was offered: "Go home and rest,there's nothing the medical profession can do for you.Good luck."
Since then,he has become an advocate for our disease,raising awareness and asking for research contributions,and expertly using his own experiences as a guideline for those who are battling this illness themselves.Through his skillful writing--he authored a compelling memoir called"Blindsided"(he has been legally blind since never fully recovering from optic neuritis)with such honesty and eloquence,never veering from the sobering truth of his debillitating condition-as well as an ongoing online column for AARP magazine,called Chronically Upbeat--Cohen has become a lifeline to others navigating through the rough waters of chronic illness,and is now a powerful voice for those seeking guidance.
We need his voice.
But don't call him brave or heroic,just determined to live life fully and to help fellow MS sufferers do the same.Cohen says:"There are no medals,no merit badges or awards given for coping; only a life lived well,with meaning and purpose,that are their own rewards."
Here are some other suggestions:
Stay connected.Healthy relationships and family support will sustain you.
(He and Meredith have been married for 26 years and have 3 children).
If you want your kids to become happy and secure adults,don't keep secrets at home. Be open and direct with them;they are smarter than you are, and will intuitively know when you are not being truthful.
A sense of humor always helps.Note the absurdity of it all,and laugh about it-try not to take it too seriously,and realize that progressive diseases progress.Make your peace with that as best you can.
Good advice from a wise man!
Tuesday, August 7, 2012
Monday, August 6, 2012
Sunday, August 5, 2012
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