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Disclaimer: 'MS Views and News' DOES NOT endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.

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CHAMPIONS TACKLING MS - AWARDS Dinner, Honoring Aaron Boster, MD and Jon e. Glaser, DDS - now open for registration. Visit www.events.msvn.org

Saturday, December 22, 2012

Lymphocyte clue to multiple sclerosis drug response


By Eleanor McDermid, Senior medwireNews Reporter

Patients with rapid recovery of CD4-positive T cells after alemtuzumab treatment formultiple sclerosis (MS) are at risk for disease progression or relapse, research suggests.

The difference was apparent from 3 months after treatment, implying the potential for individualized treatment protocols based on CD4+ counts, say lead researcher Neil Robertson (Cardiff University, UK) and colleagues.

"The association between disease activity and early lymphocyte recovery is not surprising, as MS is primarily a cell-mediated disorder," they write in Neurology. "However, this relationship has not been demonstrated in vivo before."

The researchers assessed 56 patients (40 women) given alemtuzumab 12 mg daily for 5 days to treat symptoms of MS. They observed an initial "profound depletion" of lymphocyte subsets, followed by gradual recovery.

CD19+ cells were the first to recover, reaching the 25th percentile of average pretreatment levels at 3-6 months after treatment. These were followed by CD8+ cells, which reached a similar level after 6-9 months.

Patients' average CD4+ cell counts remained below the 25th of pretreatment levels for up to 24 months of follow up (they received a second alemtuzumab course 12 months after initial treatment). However, recovery of CD4+ cells differed between patients who did and did not exhibit disease activity during follow up.



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Visualization And Holistic Management Program Conquers Multiple Sclerosis: Law of Attraction Guru Natalie Ledwell Exposes Self-Healing Techniques To Beat Chronic Disease


Visualization And Holistic Healing Beat Multiple Sclerosis: Law Of Attraction Guru Natalie Ledwell Reveals The Power To Overcome Chronic Disease With Self-Healing Practices With Medical Wonder Betty Iams


San Diego, CA (PRWEB) December 20, 2012

Mind Movies co-founder and Law of Attraction guru,Natalie Ledwell, announced the release of an episode of The Inspiration Show featuring medical miracle Betty Iams. Iams shares her incredible story of overcoming chronic disease and creating a supportive online community for thousands of individuals. Iams has a website that aims to increase awareness on the powerful effects of natural health care and visualization.
Iams was diagnosed with primary progressive multiple sclerosis when she was 58 years old. Multiple sclerosis generally is considered untreatable and incurable. Determined to fight the neurological damage caused by the disease, Iams turned to natural treatment and self-healing strategies.
“My mother was also diagnosed with MS, so I was terrified when I first received the news,” says Iams. “I had to transform my entire lifestyle before I could begin the healing process.”
Iams turned to the work of various personal development and health experts to learn holistic practices to combat disease. Iams began a consistent exercise routine, mediated daily and visualized herself at optimal health. She also discovered Mind Movies as an effective tool for recovery.
“Mind Movies is wonderful because it is not just reading affirmations off a piece of paper,” shares Iams. “It is exciting, and motivating, everything I put in my Mind Movie came true.”
Iams started the website titled “Betty’s House” in the beginning stages of her disease and released consistent reports of her progress and health. She published personal stories of her journey, the holistic practices she was utilizing and encouraged other individuals to do the same.
“I was not sure exactly what would happen when I created the site, but I was determined to create an inspirational community where others could receive free information and support,” says Iams.
18 years after the diagnosis of Multiple Sclerosis, Iams lives symptom free and doctors can no longer find any trace of evidence that she ever had the disease. Iams continues to run the website “Betty’s House" to spread her knowledge of self-healing. Iams has also written multiple books with powerful advice for overcoming chronic disease.
Over 1 million people worldwide have already received Natalie Ledwell’s free pre-made Mind Movies, which are dynamic moving video vision boards that help viewers visualize and achieve their desires and goals faster and easier than they ever thought possible.

Quote startI had to transform my entire lifestyle before I could begin the healing process.Quote end

To find out more about Mind Movies and to download 6 free pre-made Mind Movies, 
About Mind Movies:
Founded in 2007, Mind Movies’ mission is to help empower people from all over the world to visualize their goals and manifest their greatest dreams and desires. Mind Movies has touched the lives of over 1 million people around the world and is headquartered in downtown San Diego, California.
Company Contact Information:
Mind Movies
Media Relations
113 West G Street #122
San Diego, CA 92101
http://mindmoviestv.com


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"Stu's Views & MS News" / 'MS Views and News' DOES NOT endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly
.

Thursday, December 20, 2012

Ocala Florida - February 16, 2013 - Treatment Strategies, MS Relapse information and Therapeutic Symptom Management in Multiple Sclerosis


The MS Views and News organization invites you to an informative MS education program

Treatment Strategies, MS Relapse information and
 Therapeutic Symptom Management in Multiple Sclerosis


Presented By:

Lance Kim, MD - Neurology
MS Treatment Strategies, Options and Nutrition
and
Susan Dorne, OT
Therapeutic Symptom Management – Promoting Independence


Date: Saturday February 16, 2013

11:00am - Registration
11:30am – Program Begins
With Complimentary Lunch


Location:
Hilton Ocala - 3600 SW 36th Ave. 34474


~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
*** R.S.V.P. Required ***
To obtain a confirmation number:
RSVP to: stuart@msviewsandnews.org
If you do not have email, call: (954) 684-1683
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Program Sponsored with an Education Grant from:
QUESTCOR PHARMACEUTICALS


With Exhbit Displays from: Questcor (Acthar Gel), Acorda (Ampyra), DMR Wheelchair and Scooters, Bioness (L300 Walk Aide), Avanir (Neudexta), Novartis ( Gilenya),




.

Wednesday, December 19, 2012

New molecular test in clinical trials could help physicians identify multiple sclerosis earlier


December 18, 2012 2:47 pm by  | 

About 400,000 Americans have multiple sclerosis, a chronic central nervous system disease that can cause blurred vision, poor coordination, slurred speech, numbness and paralysis, among other things.
Despite the serious symptoms, diagnosis is often tricky because symptoms vary and can be hard for physicians to interpret. Gaithersburg, Maryland company DioGenix Inc. started up in 2008 to commercialize work on a lab test that could improve the diagnostic process.
Now, to fund a 150-patient clinical trial that has just begun enrolling, DioGenix has completed a $1.5 million Series B from existing investors including life science seed fund Nerveda LLC. The trial will validate its test, MS Precise, for early identification and diagnosis of multiple sclerosis.
Multiple sclerosis is characterized by scarring of the myelin sheath in nerve cells that disrupts the transmission of messages from the brain and causes inflammation. Because MS signs and symptoms are also characteristic of other nervous system disorders, the disease is typically diagnosed through a deductive process that includes medical history, physical exams, an MRI and analysis of spinal fluid.
The analysis of spinal fluid typically looks for evidence of general inflammation that’s not seen in the blood, DioGenix CEO Larry Tiffany said. But even that can’t give a definitive diagnosis and produces false positives. According to the Multiple Sclerosis Foundation, diagnosis is correct 90-95 percent of the time.
DioGenix’s lab test takes the cerebral spinal fluid test a step further, looking for gene mutations in certain spots within the B-cell genome that research has suggested are driven specifically by MS. Tiffany said the team thinks the specificity of the test could help clinicians distinguish MS from other immune-mediated neurological diseases that share similar biological features. It may also someday be able to help physicians identify more aggressive cases of MS.
In a recent study, the test outperformed the current method of analysis in patients suspected of having MS, according to the company. A more confident diagnosis would hopefully lead to better use of prescription of MS drugs, which suppress or alter the immune system and shouldn’t be used by people without the condition.
DioGenix’s test is an extension of the work of Dr. Nancy Monson’s team at the University of Texas Southwestern Medical Center. A blood test based on the same technology is also in development.
[Multiple sclerosis photo from BigStockPhotos]

Article Source: MedCity News
 

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Learn More of ACTHAR Gel - for MS relapse

Learn more about Acthar

As a member of the Questcor Community, you’ll receive:
·         Information about Acthar (repository corticotropin injection), an alternative to steroids
o    Helps speed recovery from MS relapses
o    Helps your body produce its own natural steroid hormones
o    Used for over 30 years—one of the first medications approved by the FDA for the treatment of MS relapses
Ask your healthcare provider if Acthar is right for you.
·         Monthly emails that can help you become MS informed, not misinformed
·         Access to stories, featuring personal journeys of people with MS
·         Tips and tools to help you become relapse-ready
·         Access to a free support service for people starting Acthar
·         Opportunities to attend educational events



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How to Get Into the Brain - Understanding the Human Brain


Published on Dec 19, 2012


Ryan Watts and Mark Dennis explain how they found a way for medicines to cross the blood-brain barrier, and how Genentech supports groundbreaking science


WATCH THIS INFORMATIVE VIDEO on YouTube





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Diagnosing Multiple Sclerosis


There is no single test that is proof-positive for diagnosing multiple sclerosis. However, there are accepted criteria for making the diagnosis, but even this system is imperfect.
Since diagnosing MS can be very difficult, a neurologist who specializes in treating MS should evaluate your symptoms. As many as 10% of people diagnosed withmultiple sclerosis actually have some other condition that mimics MS. Examples of other conditions that masquerade as MS include inflammation in the blood vessels, multiple strokes, vitamin deficiency, lupus, or a brain infection. Sometimes stress-related disorders can lead to a misdiagnosis of MS.

How Is a Diagnosis of Multiple Sclerosis Made?

An accurate diagnosis of multiple sclerosis is based on your medical history and a neurological exam (an exam of the function of the brain and spinal cord) using various tests. A lot depends on the skill of the doctor in asking the right questions to uncover information and to properly evaluate the signs and symptoms of a malfunctioning brain or spinal cord.
In addition to a thorough medical history and exam, a variety of specialized procedures are helpful in accurately diagnosing MS. These include imaging techniques, such as MRIspinal taps or lumbar punctures (examination of the cerebrospinal fluid that runs through the spinal column), evoked potentials (electrical tests to help determine if MS has affected a person's nerve pathways), and lab analysis of blood samples.

What Are the Accepted Criteria for a Diagnosis of Multiple Sclerosis?

  • Multiple sclerosis usually begins between 20 and 50 years of age
  • Symptoms and signs indicating disease of the brain or spinal cord
  • Evidence of two or more lesions -- or abnormal areas on the brain -- from a MRI scan
  • Objective evidence of disease of the brain or spinal cord on doctor's exam
  • Two or more episodes lasting at least 24 hours and occurring at least one month apart
  • No other explanation for the symptoms

What Does an MRI Show?

MRI is the best test to view the changes caused by multiple sclerosis. The precise image produced by MRI gives the neurologist clear evidence of inflammation in the deep parts of the brain or spinal cord that is characteristic of MS.
However, abnormal spots on the brain MRI can be caused by other conditions, so before making a diagnosis your doctor will consider all information including your symptoms and scan results. Similar lesions can be seen in older people or people with high blood pressure and diabetes.
Also, a normal MRI does not absolutely rule out a diagnosis of MS. About 5% of patients who are confirmed to have MS on the basis of other criteria, do not have lesions in the brain on MRI. These people may have lesions in the spinal cord or may have lesions that cannot be detected by MRI.

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Talking to Your Family About Multiple Sclerosis


A chronic and unpredictable disease such as multiple sclerosis has a significant impact not only on you but also on your loved ones. You are not the only one who suffers. Your partner and children must also cope with the disease and the changes it may bring.
If you have little or no physical disability, your family life may not change at all. But there may be times when you will need to change your family activities, choosing ones that are less physically demanding and time-consuming.
The most important thing to do is to communicate openly about your emotions and about issues related to MS. It is especially important for you to explain to your loved ones how MS affects you. Some symptoms of MS are not apparent to others, and family members depend on you to tell them when a problem occurs.

Children of Those With Multiple Sclerosis

Children are often worried about you and fear you will become disabled or will die. Frustration may arise when you are unable to keep up with them or to make commitments the way other parents can. Some children may also feel ashamed and embarrassed to go out in public with a parent who requires assistance with a cane or uses a wheelchair. The best way to handle these concerns is to talk about them. Ask your children questions about what they are thinking. Try to alleviate some of their concerns.

What to Tell Your Children About Multiple Sclerosis

Talking openly with your children about multiple sclerosis helps relieve their anxiety about your health. Children of all ages are very intuitive and know when something is different or has changed. Talking with your child opens the lines of communication and helps to reduce fear and stress.

When parents are reluctant to talk to their children about the disease, kids misinterpret silence as an indication that the situation is so bad that it cannot be discussed. Parents who can talk with their children about MS convey a message of trust, confidence, and strength.

When responding to questions or concerns, take into consideration your child's age and maturity level, and don't overwhelm them with information they cannot understand. If you have more than one child, it may be helpful to talk to them individually so that you can tailor your discussion to their level of understanding.

You may want to ask them how they would like to learn about MS -- reading a book alone or with you, watching a video, or going with you to a doctor's visit.

FOR Children's Reactions to Multiple Sclerosis, click here



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Sleep Problems and MS


Sleep problems, or disorders, are conditions that prevent a person from getting restful sleep and as a result, cause daytime sleepiness. There are about 80 different types of sleep disorders and about 70 million Americans suffer from them. The inability to fall asleep or to stay asleep, called insomnia, is the most common sleep disorder.
Many people with multiple sclerosis complain of insomnia or broken sleep patterns, yet sleep problems may not directly be the result of the disease itself. Many sleep problems occur because of secondary factors such as stressspasticityinactivity, or depression that people with MS often have. Other symptoms of sleep problems may be caused by the location of MS lesions within the brain.
People with MS often have trouble staying asleep because of spasticity, especially in the legs, or an increased need to go to the bathroom at night because of bladder problems. Talk to your doctor about what is keeping you up at night; there may be medications he or she can prescribe to improve the problem.

How Can I Get a Good Night's Sleep With Multiple Sclerosis?

If you have multiple sclerosis, one of the most important ways to ensure a good night's sleep is to create a consistent bedtime routine. Here are some tips to get you sleeping soundly.
  • Relax in the evening before going to bed. Try to not rehash the day's problems or worry about tomorrow's schedule.
  • Go to bed when you're tired. Try to be consistent about the time you go to bed.
  • Prepare yourself for bed by wearing comfortable nightclothes, adjust your bed pillows in a comfortable position, turn off the lights, adjust the temperature in your bedroom, and position yourself comfortably in your bed.
  • If you do not fall asleep after 10-15 minutes -- get up! Do not lie in bed and watch the clock or count the cracks in the wall. Find something to do that is relaxing to you, such as putting together a puzzle, reading, or writing a letter to a friend. Rather than watching TV, which is a passive activity, do something active so that natural tiredness can build up. Remember your bed is only for sleeping. Any of the above activities should be done out of bed. Return to the bed only when you feel tired.
Also, try to adhere to the following suggestions.



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Runaway Use of Radiation Harming Patients


Eric J. Topol, MD
 DisclosuresDec 17, 2012(see link below to listen to this report)
Hello. I'm Dr. Eric Topol, Director of the Scripps Translational Science Institute and Editor-in-Chief of Medscape Genomic Medicine and theheart.org. In this series, The Creative Destruction of Medicine, named for the book I wrote, I'm trying to zoom in on critical aspects of how the digital world can create better healthcare.
The topic here is radiation and how we're not doing the right things for patients. We have a serious problem with overcooking radiation in the United States. It's by far worse here than anywhere else in the world. We have runaway uses of nuclear scans, CT scans, and PET scanning, and we don't even warn our patients; we don't give patients any data on the dangers. In my book, imaging is a really important topic because there's so much progress in imaging and use of nonionizing radiation like ultrasound or MRI, but we continue to rely heavily on scans. In cardiology, for example, there are more than 10 million nuclear scans being performed each year, mostly CT scans. We know from all the data we have today that 2%-3% of cancers in this country are related to use of medical imaging and ionized radiation.
So, why don't we tell patients when they have a particular imaging scan exactly how many millisievert (mSv) they're getting exposed to? A CT angiogram of the heart is 16 mSv; a lot is being done to try to reduce that, but that is equivalent to 800 chest x-rays. How about a typical nuclear scan? A lot of patients who are treated in cardiology get this done every year. At 41 mSv, it's equivalent to 2000 chest x-rays. But patients aren't told any of this. And not only that, but we could actually measure exactly how many mSv they got by using the same type of radiation badges that the medical professionals use when they work in a cardiac cath lab or in an x-ray suite. But we don't do that. This is a serious breach of our responsibility to patients
Continue reading OR listen to this report by clicking here


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Tuesday, December 18, 2012

What You Can Do About Fatigue From MS ?


Medically speaking, fatigue is not the same thing as tiredness. Tiredness happens to everyone -- it is an expected feeling after certain activities or at the end of the day. Usually you know why you are tired and a good night's sleep solves the problem.
Fatigue is a daily lack of energy; unusual or excessive whole-body tiredness not relieved by sleep. It can be acute (lasting a month or less) or chronic (lasting from one to six months or longer). Fatigue can prevent a person from functioning normally and affects a person's quality of life.
According to the National Multiple Sclerosis Society, 80% of people with MS have fatigue. MS-related fatigue tends to get worse as the day goes on, is often aggravated by heat and humidity, and comes on more easily and suddenly than normal fatigue.

What Can I Do About MS-Related Fatigue?

The best way to combat fatigue related to your MS is to treat the underlying medical cause. Unfortunately, the exact cause of MS-related fatigue is often unknown, or there may be multiple causes. However, there are steps you can take that may help to control fatigue. Here are some tips:

1. Assess your personal situation.

  • Evaluate your level of energy. Think of your personal energy stores as a "bank." Deposits and withdrawals have to be made over the course of the day or the week to balance energy conservation, restoration, and expenditure. Keep a diary for one week to identify the time of day when you are either most fatigued or have the most energy. Note what you think may be contributing factors.
  • Be alert to your personal warning signs of fatigue. Fatigue warning signs may include tired eyes, tired legs, whole-body tiredness, stiff shoulders, decreased energy or a lack of energy, inability to concentrate, weakness or malaise, boredom or lack of motivation, sleepiness, increased irritability, nervousness, anxiety, or impatience.

2. Conserve your energy.


Plan ahead and organize your work. For example, change storage of items to reduce trips or reaching, delegate tasks when needed, and combine activities and simplify details.
Schedule rest. For example, balance periods of rest and work and rest before you become fatigued. Frequent, short rests are beneficial.
Pace yourself. A moderate pace is better than rushing through activities. Reduce sudden or prolonged strains. Alternate sitting and standing.
Practice proper body mechanics. When sitting, use a chair with good back support. Sit up with your back straight and your shoulders back. Adjust the level of your work. Work without bending over. When bending to lift something, bend your knees and use your leg muscles to lift, not your back. Do not bend forward at the waist with your knees straight. Also, try carrying several small loads instead of one large one, or use a cart.
Limit work that requires reaching over your head. For example, use long-handled tools, store items lower, and delegate activities whenever possible.
Limit work that increases muscle tension.
Identify environmental situations that cause fatigue. For example, avoid extremes of temperature, eliminate smoke or harmful fumes, and avoid long hot showers or baths.
Prioritize your activities. Decide what activities are important to you, and what could be delegated. Use your energy on important tasks.

3. Eat Right

Fatigue is often made worse if you are not eating enough or if you are not eating the right foods. Maintaining good nutrition can help you feel better and have more energy.

4. Exercise

Decreased physical activity, which may be the result of illness or of treatment, can lead to tiredness and lack of energy. Scientists have found that even healthy athletes forced to spend extended periods in bed or sitting in chairs develop feelings of anxiety, depression, weakness, fatigue, and nausea. Regular, moderate exercise can decrease these feelings, help you stay active, and increase your energy.

5. Learn to manage stress

Managing stress can play an important role in combating fatigue. Here are tips to help keep stress in check:
Adjust your expectations. For example, if you have a list of 10 things you want to accomplish today, pare it down to two and leave the rest for other days. A sense of accomplishment goes a long way to reducing stress.
Help others understand and support you. Family and friends can be helpful if they can "put themselves in your shoes" and understand what fatigue means to you. Support groups can be a source of comfort as well. Other people with MS understand what you are going through.
Relaxation techniques. Audiotapes that teach deep breathing or visualization can help reduce stress.
Participate in activities that divert your attention away from fatigue. For example, activities such as knitting, reading, or listening to music require little physical energy but require attention.


If your stress seems out of control, talk to your doctor. They are there to help.
When Should I Tell My Doctor About My Fatigue?


Although fatigue is a common and often expected symptom of MS, you should feel free to mention your concerns to your doctors. There are times when fatigue may be a clue to some other underlying medical problem. Other times, there may be medical interventions that can prevent fatigue.

Source: WebMD
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Monday, December 17, 2012

Benefits of Exercise and Our New Partnership with LA Fitness


HAPPY HOLIDAYS - To EACH of YOU,
 from all at MS Views and News /Stu's Views & MS News


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Everyone is told, at one time or another, to exercise but do you really understand why?  The benefits of exercise are numerous and I will start by addressing health issues.  Exercise can help improve natural protection against cold and flu viruses, reduce risks of high blood pressure, Type II Diabetes, heart disease, decrease cholesterol, and help prevent physical and mental problems related to aging.  It plays an important role in reducing depression, enhancing self-esteem, increasing productivity and concentration, improving quality of sleep, and lowering overall health care costs.

            Exercise is essential for individuals with MS.  Exercise programs strengthen weak muscles, lessen fatigue, increases muscular and cardiovascular endurance, helps correct bladder control issues, increases bone density, as well as manages weight control.  Not only have I seen the benefits directly as a trainer but I am aware of how important it is for people with MS. My mother has had MS for over 15 years and she inspires me every day to help anyone and everyone I come across. Now I am here to help our MS community by encouraging health and wellness, so one day we can beat this together!

            I am dedicated to helping the MS community any way I can.  As Corporate Wellness Director at LA Fitness, I have coordinated a tailored made program that I can offer anyone associated with MS Views and News.  

If you receive any type of MS Views and News (MSVN) correspondence via e-newsletter, email, website, program, or know someone who does, this pertains to YOU!  However, I am the only Wellness Director authorized to provide this opportunity and time is limited.  

This offer is good for any LA Fitness, Lifestyle Family Fitness, Bally Total Fitness, and Urban Active health clubs throughout the entire United States (Excluding New York and Signature clubs). For the racquetball lovers, I was able to give you free use of courts as part of your new membership with LA Fitness. Not to mention we were also able to remove the initiation fee of $150 per person.   

            Please be aware that the opportunity is only open for a limited time.  Do not hesitate to contact me to assist you through the process and I will make myself available at your convenience. I want to make a difference; “Solutions for the 21st century.”

            Now it is really simple to get on board and start a better lifestyle. Just email MSVN at msvnhealth@gmail.com to inquire about a voucher to sign up. All they need is your first name, last name, email, and phone number and they will be able to send you a voucher immediately. If there is more than one person signing up you will need to email them their contact information as well. Everyone signing up needs their own voucher. Now what do you do with this voucher?

            It is straightforward just go to www.lafitness.com/corporatewellness  enter in your voucher number. Then choose your home club as Oviedo (it is on page 6 of 10) this will help me out greatly and it will give me credit for your new membership, insert all your information and you’re all done. This membership will allow you to use any facility other than those in New York or the Signature Clubs, as the special does not apply to them.  Again if you have any questions feel free to contact me via email or cell phone.

Welcome to the team and we look forward to seeing you closer than ever to all your goals!

Sincerely,
Seth Dorne  Corporate Wellness Director
786-586-4271        (w) 407-977-8177          sdorne@knights.ucf.edu

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Sunday, December 16, 2012

Dietary interventions for multiple sclerosis


 2012 Dec 12;12:CD004192. doi: 10.1002/14651858.CD004192.pub3.

Dietary interventions for multiple sclerosis.

Source

Neuroepidemiology Unit, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, via Celoria 11, Milano, Italy, 20133.

Abstract

BACKGROUND:

Clinical and experimental data suggest that certain dietary regimens, particularly those including polyunsaturated fatty acids (PUFAs) and vitamins, might improve outcomes in people with multiple sclerosis (MS). Diets and dietary supplements are much used by people with MS in the belief that they might improve disease outcomes and overcome the effectiveness limits of conventional treatments.This is an update of the Cochrane review "Dietary intervention for multiple sclerosis" (first published on The Cochrane Library 2007, Issue 1).

OBJECTIVES:

To answer MS patients' questions regarding the efficacy and safety of dietary regimens for MS. Can changes in dietary habits be an effective intervention for MS patients? Are the potential side effects of these interventions known, and have they been measured? Are potential interactions between dietary interventions and other curative or symptomatic treatments known and have they been studied?

SEARCH METHODS:

We searched the Cochrane Multiple Sclerosis and Rare Diseases of the Central Nervous System Group Specialised Register (November 2011), CENTRAL (The Cochrane Library 2011, Issue 4), MEDLINE (PubMed) (1966 to November 2011), EMBASE (embase.com) (1974 to November 2011) and reference lists of papers found.

SELECTION CRITERIA:

All controlled trials (randomised controlled trials (RCTs) and controlled clinical trials (CCTs)) on a specific dietary intervention, diet plan or dietary supplementation, except for vitamin D supplementation, compared to no dietary modification or placebo were eligible.

DATA COLLECTION AND ANALYSIS:

Two review authors independently selected articles, assessed trial quality and extracted data. Data were entered and analysed in RevMan.Dichotomous data were summarised as relative risks (RR) with 95% confidence intervals (95% CI) using a random-effects model in the presence of heterogeneity (I² > 60%). Continuous data were analysed using weighted mean differences, determined by the difference between the pre- and post-intervention changes in the treatment and control groups.

MAIN RESULTS:

Six RCTs that investigated PUFAs emerged from the search strategy, accounting for 794 randomised patients.PUFAs did not have a significant effect on disease progression at 24 months. Omega-6 fatty acids (11 to 23 g/day linoleic acid) didn't show any benefit in 144 MS patients (RR 1.04, 95% CI 0.66 to 1.63). Linoleic acid (2.9 to 3.4 g/day) had no benefit in 65 chronic progressive MS patients (RR 0.78, 95% CI 0.43 to 1.42). Omega-3 fatty acids had no benefit in 292 relapsing remitting MS patients (RR 0.82, 95% CI 0.65 to 1.03, P = 0.08).Slight potential benefits in relapse outcomes were associated with omega-6 fatty acids in some studies, however these findings were limited by the reduced validity of the endpoints. No judgements about safety or patient-reported outcomes were possible. In general, trial quality was poor.No studies on vitamin supplementation and allergen-free diets were analysed as none met the eligibility criteria, mainly due to lack of clinical outcomes.

AUTHORS' CONCLUSIONS:

PUFAs seem to have no major effect on the main clinical outcome in MS (disease progression), but they may tend to reduce the frequency of relapses over two years. However, the data that are available are insufficient to assess a real benefit or harm from PUFA supplementation because of their uncertain quality.Evidence on the possible benefits and risks of vitamin supplementation and antioxidant supplements in MS is lacking. More research is required to assess the effectiveness of dietary interventions in MS.
PMID:
 
23235605
 
[PubMed - in process]

Source: PubMed


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