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Friday, February 22, 2013

Stem Cell Therapy for Patients With Multiple Sclerosis Failing Interferon A Randomized Study - at Northwestern University


This study is currently recruiting participants.
Verified December 2012 by Northwestern University
Sponsor:
Collaborators:
Rush University Medical Center
University of Sao Paulo
Uppsala University
Information provided by (Responsible Party):
Richard Burt, MD, Northwestern University




Purpose
Multiple sclerosis (MS) is at onset an immune-mediated demyelinating disease. In most cases, it starts as a relapsing-remitting disease with distinct attacks and no symptoms between flares. Over years or decades, virtually all cases transition into a progressive disease in which insidious and slow neurologic deterioration occurs with or without acute flares. Relapsing-remitting disease is often responsive to immune suppressive or modulating therapies, while immune based therapies are generally ineffective in patients with a progressive clinical course. This clinical course and response to immune suppression, as well as neuropathology and neuroimaging studies, suggest that disease progression is associated with axonal atrophy. Disability correlates better with measures of axonal atrophy than immune mediated demyelination. Therefore, immune based therapies, in order to be effective, need to be started early in the disease course while MS is predominately an immune-mediated and inflammatory disease. While current immune based therapies delay disability, no intervention has been proven to prevent progressive disability. We propose, as a randomized study, autologous unmanipulated PBSCT using a conditioning regimen of cyclophosphamide and rATG versus FDA approved standard of care (i.e. interferon, copaxone, or mitoxantrone) in patients with inflammatory (relapsing) MS despite treatment with interferon.


Read more of this study from Clinical Trials.gov -
CLICK: http://clinicaltrials.gov/show/NCT00273364


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