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"In the introduction the investigators suggest that headache may be due to inflammation, in particular B cell follicles, in the meninges (membranes covering the brain) of MSers. Why? Interestingly, the actual brain substance is devoid of pain fibres or pain receptors. The pain sensitive structures in the brain that cause headache or the blood vessels (arteries, veins and venous sinuses), meninges (membranous coverings of the brain), cranial nerves, paranasal air sinuses, skull and scalp. These investigators suggest that inflammation in the meninges and around blood vessels is causing headaches in MSers. However, they provide no evidence that this is the case. If this was the case then treatment with anti-inflammatory agents to reduce inflammation should reduce headaches. This data may be available in trial databases, but as it hasn't been collected systematically it won't be very useful."
"The MS inflammation-headache hypothesis may be a subject to study in more detail using questionnaires given pre and post DMTs and using MRI and CSF analysis to quantify inflammation and to see if it correlates with headache. if this was the case then headaches could be another sign of MS disease activity. In other words if you develop headache, or your headaches get worse, this may indicate that your MS is active."
Background: Recent studies on MS pathology mention the involvement of "tertiary B cell follicles" in MS pathogenesis. This inflammatory process, which occurs with interindividually great variance, might be a link between MS pathology and headaches.
"To try and replicate this studies findings I would appreciate it if you could complete this short survey. Thank you."
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