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Monday, December 16, 2013

Stepping Toward a Different Relapse Option

it’s your move—have you seen the NEW MS Relapses video?
In this video, you’ll find out how taking control of an MS relapse starts with you. Learning more about MS relapses, what causes them, and treatment options like H.P. Acthar® Gel (repository corticotropin injection) can help you treat them.


Don’t miss this unique opportunity to:
EXPLORE signs of an MS relapse that may surprise you
LEARN what happens to the body during a relapse
DISCOVER how Acthar is believed to work in 2 ways to help impact the inflammatory processes*:
Directly with your immune system and central nervous system and with your body to help it produce its own natural steroid hormones (cortisol, corticosterone, and aldosterone). These natural hormones may help reduce inflammation causing your relapse
Acthar is believed to affect T cells and B cells. This action is believed to impact the inflammatory processes

P.S. Want to learn more? Sign up for an upcoming event, and talk to your healthcare provider about Acthar today.
*While the exact mechanism of action of Acthar is unknown, further investigation is being conducted. This information is based on nonclinical data and the relationship to clinical benefit is unknown.
H.P. Acthar® Gel (repository corticotropin injection) is an adrenocorticotropic hormone (ACTH) analogue used for the treatment of acute exacerbations of multiple sclerosis in adults.
Please see Important Safety Information below and full Prescribing Information.
H.P. Acthar® Gel and Questcor® are registered trademarks of Questcor Pharmaceuticals, Inc.
©2013 Questcor Pharmaceuticals, Inc.     PM-01-01-0214   11/13

Important Safety Information
H.P. Acthar® Gel (repository corticotropin injection) is indicated for the treatment of acute exacerbations of multiple sclerosis in adults. Controlled clinical trials have shown H.P. Acthar Gel to be effective in speeding the resolution of acute exacerbations of multiple sclerosis. However, there is no evidence that it affects the ultimate outcome or natural history of the disease.
Patients, parents, and caregivers should be aware of the important information about
H.P. Acthar® Gel.
Acthar should never be given intravenously (into a vein). Acthar should not be used in patients with a skin condition called scleroderma, bone density loss (osteoporosis), infection throughout the body, eye infection called ocular herpes simplex, recent surgery, history of or a current stomach ulcer, heart problems, high blood pressure, or allergy to pig-derived proteins. Tell your doctor about any health problems or medicines.
Acthar may cause side effects similar to side effects that happen due to treatment with steroid medicines. Not all of these side effects have occurred with Acthar but they may occur. Acthar is a medicine that affects a patient's immune system, and therefore patients may be more likely to get new infections, or inactive infections may become active. Acthar has effects on the adrenal gland. When a patient is taking Acthar, their adrenal gland may produce too much of a hormone called cortisol. This can cause symptoms of Cushing's syndrome (upper body fat, rounded face, thin skin), which is more common in patients who take this medicine for a long time. When a patient stops taking Acthar after a long time, the body may not produce enough cortisol on its own (adrenal insufficiency). The doctor may prescribe a steroid medicine to protect the body until the adrenal gland recovers. Do not stop administering Acthar without talking to your doctor first. Your doctor may check your blood pressure during treatment and may instruct you to make some dietary changes. Patients should not receive certain vaccines during treatment with Acthar. Talk to your doctor about which vaccines are safe for use. Acthar may hide (or mask) symptoms of other conditions or diseases and it may be more difficult for your doctor to diagnose other conditions or diseases in you or your child during treatment. The person receiving Acthar has an increased risk for bleeding from the stomach or having a stomach ulcer. Inform your doctor about any pain in the stomach area, bloody vomit, or bloody or black stools. While on Acthar changes in mood and behavior such as irritability, depression, or trouble sleeping, may occur.
Other side effects are possible. Acthar may make certain other medical conditions worse, such as diabetes (may increase blood sugar); cause eye problems, such as cataracts, increased pressure in the eye (glaucoma), and possible damage to the optic nerve; and cause allergic reactions to Acthar (seen as skin rash, swelling of the face, tongue, lips, or throat, and trouble breathing). Acthar may affect growth and physical development after long term use. Long term use of Acthar may cause an increase in the size of the heart, but this condition usually goes away after Acthar is stopped.
The most common side effects of Acthar in infants include: infections, increased blood pressure, irritability and changes in behavior, changes in appetite and weight, diarrhea, and vomiting. Other adverse reactions reported in adults and children over 2 years of age included: abdominal bloating, anxiety, asthma, chest discomfort, congestive heart failure, dizziness, shortness of breath, redness of the face, fluid retention, flushing, headache, injection site pain, tiredness, muscle weakness, nervousness, rapid heart rate and lack of energy. Tell your doctor if there is any side effect that bothers you or your child or that does not go away.
These are not all of the possible side effects of Acthar. For more information, ask your doctor, nurse, or pharmacist, go to, or call 1-800-465-9217. You may report side effects to the FDA at 1-800-FDA-1088.
For a full list of indications, contraindications, warnings, precautions, and adverse events related to Acthar, please refer to the full Prescribing Information.

This information is intended only for residents of the United States.
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Questcor Pharmaceuticals, Inc., 26118 Research Road, Hayward, CA 94545.


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