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Sunday, June 1, 2014

ALTERNATIVE Therapies: Bio-Enhanced TURMERIC Compounds Block Multiple Inflammatory Pathways

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By Michael Downey - Life Extension Magazine

Bio-Enhanced TURMERIC Compounds Block Multiple Inflammatory Pathways  
Millions of Americans suffer from chronic pain caused by inflammation, while millions more suffer diseases caused bychronic inflammation such as cancer and atherosclerosis.1,2
Prescription options—non-steroidal anti-inflammatory drugs(NSAIDs) and glucocorticoids—target only part of the overall chronic inflammatory response. Worse, they have substantial side effects and are not meant for long-term use.3,4
After combing through scores of nutrients, scientists have identified three compounds: curcumin, ginger, and turmeric oil that inhibit multiple underlying factors behind inflammation—safely reducing both chronic pain and long-term disease risk.
Numerous studies have confirmed that—by targeting the inflammatory origins—these natural extracts reduce the symptoms, risk profiles, and mediating factors of arthritis,5-12 cardiovascular disease,5,13-17 cancer,18-22 and other diseases…and some of these effects are observable in a matter of weeks!9,16,18,23
Even more exciting, scientists have discovered a novel way to deliver more of these three extracts to your bloodstream—almost seven times as much!24-27 These groundbreaking discoveries enhance the ability of these compounds to block the origins of chronic inflammation.

An All-Out Assault On Chronic Inflammation

When levels of certain cellular enzymes are increased, the result is chronic inflammation created by a complex “domino effect” of signaling molecules known as prostaglandins andleukotrienes.28-30 As scientists now know, the more inflammation, particularly chronic inflammation, you have, the more rapidly your body ages.1
In fact, we know that almost all chronic diseases—from arthritis, to heart disease, to diabetes, to Alzheimer’s disease—have one thing in common: destructive, unchecked inflammation.31
Doctors have long known of individual compounds that can inhibit one of the steps involved in chronic inflammation, producing some anti-inflammatory response. For example, NSAIDs inhibit the production of prostaglandin signaling molecules by blocking enzymes known as COX-1 andCOX-2. But they are not well characterized in terms of their ability to inhibit production of leukotriene signaling molecules, which requires blocking the LOX enzyme.32
Researchers sought natural compounds that could inhibit the multiple steps behind prostaglandin and leukotriene production to deliver broad-spectrum protection against chronic inflammation.
Unlike current medications, turmeric oil, ginger oil, and curcumin work through multiple mechanisms to block multiple pathways of the inflammation-signaling process.5,32-40
It makes sense that these extracts have similar anti-inflammatory effects—they belong to the same plant family, known as Zingiberaceae.41
Turmeric Root Compounds  

Turmeric Root Compounds

Curcumin is packed with potent chemicals, collectively known ascurcuminoids.42
Turmeric oil - the liquid produced during curcumin extraction43,44- is rich in compounds known as aromatic turmerones.

Ginger Root Compounds

Ginger Root Compounds  
Ginger oil contains gingerolsshogaols, and sesquiterpenes, which are powerful anti-inflammatory active compounds.45
To illustrate a key element of their dramatically broadereffectiveness against inflammation, these natural ingredients deliver a potent benefit that no currently available drug can—they block both COX and LOX enzymes, which in turn inhibits synthesis of both prostaglandin and leukotriene signaling molecules!32-40
This is of vital importance, because scientists have now discovered that agents that trigger dualinhibition of COX and LOX enzymes potentially provide “a better therapeutic profile” and produce almost no side effects compared to NSAIDs.32
Remarkably, when these three extracts are combined, they help prevent chronic inflammation by favorably modulating the activity of the following pathways. They:
  • Inhibit COX-1 and COX-2 enzymes;33-35
  • Inhibit LOX enzyme;36-38
  • Inhibit inducible nitric oxide (iNOS);33,36-38
  • Inhibit NF-kappaB;34,37,46
  • Inhibit degradation of IkappaB-alpha;46
  • Exert potent antioxidant activity —scavenging superoxide and hydroxyl radicals and reducing lipid peroxidation, early steps in the inflammation cascade,5,37 and inhibiting transcription of cell surface receptors for oxidized LDL cholesterol;47
  • Inhibit stimulated increase of prostaglandin E2 (PGE2).33
How these natural ingredients work at the cellular level may seem technical, but what you need to remember is that they are not synthetic drugs that are alien to your body’s systems. Instead, theywork with your body’s own processes to help bring back natural function. Before we look at the many health benefits of these extracts, let’s learn how scientists have combined all three—in a novel formulation that also delivers a further potent advantage: it naturally enhances absorption.

Continue reading from: Enhanced-Absorption Formula
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