REPAIR, REGENERATE & RENEW: Cutting-Edge Stem Cell Research at Tisch MS Research Center of New York
REGENERATEIn 2007, we started the process of obtaining FDA approval for a Phase I clinical trial. Finally, in August 2013, we received FDA approval to move ahead!
Why Stem Cells?
In pre-clincal, non-human experiments of our stem cell therapy, renewal, repair and regeneration of myelin occurred in the CNS after intrathecal (via spinal fluid, not intravenous) injection.
From our preclinical models, we know that stem cells injected into the spinal fluid can have significant benefit in terms of improved neurological symptoms.
MS is characterized by brain inflammation, loss of myelin, damage to oligodendrocytes (the cells that make myelin), damage to neurons, and scar formation in the brain. As a result, nerve signals are not properly conducted, causing loss of neurological function. Stem cells are hypothesized to promote repair in MS by migrating to areas of demyelination, blocking damage-forming events, and enabling repair.Why Neural Stem Cells?
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