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Thursday, June 5, 2014

REPAIR, REGENERATE & RENEW: Cutting-Edge Stem Cell Research

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REPAIR, REGENERATE & RENEW: Cutting-Edge Stem Cell Research at Tisch MS Research Center of New York

Our adult stem cell treatment received FDA approval for a Phase I Clinical Trial that has the potential to repair the damage caused by MS.
This exciting milestone took over ten years to reach and brings indescribable hope to MS patients and their loved ones all over the world. 

REPAIR

Our stem cell therapy is the star of the research program at the Tisch MS Research Center of New York (Tisch MSRCNY), a 501(c)(3), independent, non-profit research center dedicated to finding the cause of and cure for multiple sclerosis (MS). The Center focuses on patient-based research, bringing findings rapidly from the laboratory into clinical application to treat symptoms of MS and to halt or reverse damage caused by the disease. 


REGENERATE

In 2007, we started the process of obtaining FDA approval for a Phase I clinical trial. Finally, in August 2013, we received FDA approval to move ahead!
  • The objective of the Phase I trial is to test safety.
  • Data from the Phase I trial will lead to an improved strategy for Phase II
  • Positive outcomes of the trial may indicate the use of this therapy in other neurological diseases like ALS and Parkinson's Disease, cerebral palsy and spinal cord injuries.
Why Stem Cells? 
In pre-clincal, non-human experiments of our stem cell therapy, renewal, repair and regeneration of myelin occurred in the CNS after intrathecal (via spinal fluid, not intravenous) injection.

From our preclinical models, we know that stem cells injected into the spinal fluid can have significant benefit in terms of improved neurological symptoms.

 MS is characterized by brain inflammation, loss of myelin, damage to oligodendrocytes (the cells that make myelin), damage to neurons, and scar formation in the brain. As a result, nerve signals are not properly conducted, causing loss of neurological function. Stem cells are hypothesized to promote repair in MS by migrating to areas of demyelination, blocking damage-forming events, and enabling repair. 
Why Neural Stem Cells?

To learn more, click here





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1 comment:

daveburton said...

This is exciting!

Note that they are using autologous stem cells (from the patient's own body), not the controversial embryonic stem cells harvested from the bodies of aborted babies, so there are no ethical clouds hanging over this research.