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Disclaimer: 'MS Views and News' DOES NOT endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.

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Saturday, July 12, 2014

Evaluation of the Effects of Sativex (THC BDS: CBD BDS) on Inhibition of Spasticity in a Chronic Relapsing Experimental Allergic Autoimmune Encephalomyelitis: A Model of Multiple Sclerosis.

Abstract

This study investigated the antispasticity potential of Sativex in mice. Chronic relapsing experimental allergic encephalomyelitis was induced in adult ABH mice resulting in hind limb spasticity development. Vehicle, Sativex, and baclofen (as a positive control) were injected intravenously and the "stiffness" of limbs assessed by the resistance force against hind limb flexion. Vehicle alone caused no significant change in spasticity. Baclofen (5 mg/kg) induced approximately a 40% peak reduction in spasticity. Sativex dose dependently reduced spasticity; 5 mg/kg THC + 5 mg/kg CBD induced approximately a 20% peak reduction; 10 mg/kg THC + 10 mg/kg CBD produced approximately a 40% peak reduction in spasticity. Sativex has the potential to reduce spasticity in an experimental mouse model of multiple sclerosis (MS). Baclofen reduced spasticity and served as a positive control. Sativex (10 mg/kg) was just as effective as baclofen, providing supportive evidence for Sativex use in the treatment of spasticity in MS.
View graphs and continued information from PubMed

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Management about Spasticity

The goals of treatment of spasticity include retention of function, particularly related to mobility and the ability to perform activities of daily living; prevention of any permanent orthopedic deformity or development of pressure ulcers; reduction of pain; and stretching to achieve appropriate fit with orthotics.
Treatment of spasticity will be influenced by severity, location, duration, success of any prior treatment, functional status and future plans, any comorbidities, the likelihood of compliance with treatment, and the availability of a support system and a plan for follow-up. Before spasticity becomes an issue, patients should be managed with preventive measures in place. There is not a stepwise algorithm for treatment of spasticity resulting from MS, and many therapeutic measures may be utilized concurrently or interchangeably.
Source: http://www.healthline.com/health/multiple-sclerosis/symptomatic-treatment-spasticity-multiple-sclerosis




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MS Views and News aka MS News and Views to host a

MS Views and News / MS News and Views

Will host an education program on August 9th in Pensacola, Florida
This will be the organizations first program in the Pan Handle since 2011 when they provided a program in Destin, Fl.

With the width of the panhandle, MS Views and News expects a nice turnout at this August 9th program.

For more detail see below

MS Views and News, Inc., a not for profit organization will host an informative Multiple Sclerosis education program

REALLY? – But You Look SO GOOD!
A Look at the Invisible Symptoms of MS


Treatment Options and Primary Symptoms that cause dysfunction in Multiple Sclerosis
Including: Memory and Bladder issues, Fatigue, Pain, Optic Dysfunction, PLUS Dietary & Self Aspects

*** RSVP Required ** see below

Presented By:
Brian Steingo MD – MS Neurologist, Researcher
and Medical Director of Comprehensive MS Center in Pompano, Fl.


Date: Saturday, August 9, 2014
10:50am – Registration
11:25am – Program Begins
With Complimentary Luncheon


Program Location: Crowne Plaza Pensacola
200 East Gregory Street - Pensacola, Florida 32501


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R.S.V.P. Required 

RSVP online at: www.events.msvn.org
If No Internet, call Jill at: (203) 550-7703
(No Children under 16 will be permitted unless the pediatric child has Multiple Sclerosis)
Maximum of 50 people 

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MS Views and News
aka MS News and Views

Cognition in multiple sclerosis: Researchers publish results of one of the longest longitudinal studies

Date:June 24, 2014

Source: Kessler Foundation

Summary:
One of the longest longitudinal studies of cognition in multiple sclerosis has been completed, and its results published. These results provide insight into the natural evolution of cognitive changes over time, an important consideration for researchers and clinicians. "These longitudinal data contribute substantially to our knowledge of the course of cognitive decline in MS," noted one expert.

Researchers at Kessler Foundation and the Cleveland Clinic have published one of the longest longitudinal studies of cognition in multiple sclerosis (MS). Results provide insight into the natural evolution of cognitive changes over time, an important consideration for researchers and clinicians.

Authors are Lauren B. Strober, PhD, of Kessler Foundation and Stephen M. Rao, PhD, Jar-Chi Lee, Elizabeth Fisher, PhD, and Richard Rudick, MD, of the Cleveland Clinic.

"While cognitive impairment is known to affect 40 to 65% of individuals with MS, few studies have followed the pattern of cognitive decline over time, which is important for understanding long-term care and outcomes associated with MS," said Dr. Strober, senior research scientist at Kessler Foundation. "Our study was based on a unique sample of 22 patients who underwent neuropsychological testing at entry into the original phase 3 clinical trial of intramuscular interferon beta-1a, and again at 18-year followup."

At baseline, 9 patients (41%) had cognitive impairment; at 18-year followup, 13 patients (59%), were found to be impaired. Significant declines over time were found in information processing speed, auditory attention, memory, episodic learning and visual construction. Decline was steeper in the unimpaired than in the impaired group, as indicated by the Symbol Digit Modalities Test (SDMT).

"These longitudinal data contribute substantially to our knowledge of the course of cognitive decline in MS," noted John DeLuca, PhD, VP of Research & Training at Kessler Foundation. "In light of the young age at diagnosis, this perspective is fundamental to the development of rehabilitation strategies that meet the needs of people dealing with the cognitive effects of MS."

Additional information found at the Source for this article, found here (Science Daily)


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Friday, July 11, 2014

MS Study on perceptions and experiences with the disease

If you have MS and live in: UK, Ireland, Spain, Italy, France, Germany, Russia, Greece and are available to chat with a friend here in the states who is looking to talk to PWMS about their perceptions and experiences with the disease. 

It's completely anonymous. She just needs 15-30 minutes of your time and she will send you a $50 gift card.




Monday, July 7, 2014

National MS Society-Supported Researchers Use Novel Technology To Identify FDA-Approved Compounds that May Stimulate Myelin Repair in MS

July 7, 2014
A team at the University of California at San Francisco led by Jonah Chan, PhD,  has identified a group of compounds approved by the U.S. Food and Drug Administration (FDA) for various disorders that might also stimulate myelin repair. They report the findings in Nature Medicine (Published online July 6, 2014). This study was mainly funded by friends of the MS Research Group at UCSF, with additional support from the National MS Society Harry Weaver Neuroscience Scholar Award to Dr. Chan and the UCSF Clinical & Translational Science Institute Catalyst Award for Innovation.
Background: In MS, the immune system attacks and destroys myelin, the fatty substance that surrounds and protects the nerve fibers, and the nerve fibers can also be damaged. Current therapies are largely aimed at dampening the immune system. However, a therapy that repairs damage to myelin and nerve fibers is also necessary.
Decades of research into nerve physiology, MS tissue damage and the biology of glial cells – the numerous brain cells that support nerve cells – have laid the groundwork for finding ways to repair damage and restore normal function in individuals with MS. Achieving this goal is a priority of research supported by the National MS Society.
One challenge in developing repair strategies has been identifying possible therapeutic targets. The fact that compounds need to be observed for their ability to form myelin around nerve fibers has limited the speed at which  the impact of compounds could be screened. This study reports on a novel technology developed by Dr. Jonah Chan that could revolutionize the development of myelin repair strategies. In September 2013, Dr. Chan was the first recipient of the Barancik Prize for Innovation in MS Research, a new international prize launched to recognize innovation and progress in MS research, for his pioneering work in applying this technology to the search for ways to stimulate brain repair in people who have MS. Read more
The Study: Dr. Chan’s team invented new nanofiber and micropillar technology to rapidly identify compounds that stimulate the regrowth of myelin. The “Binary Indicant for Myelination on Micropillar Arrays” (BIMA) uses arrays of tiny fabricated “micropillars” that simulate nerve fibers. Myelin-making cells called oligodendrocytes form myelin around each micropillar, looking somewhat like the rings of a tree, enabling an automated readout to permit the team to study functional myelination.
The team initiated a screen using this technology, testing 1000 molecules for their ability to promote oligodendrocyte development and wrapping of myelin around the micropillars.  
Continue to read this article by clicking here, which will redirect you to the source of this informative article


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Sunday, July 6, 2014

iPad becomes powerful multiple sclerosis management tool at Cleveland Clinic

Tracking patients’ progress is a critical part of managing multiple sclerosis (MS), a dreaded inflammatory disease of the central nervous system (CNS) that too frequently afflicts people beginning in young adulthood, particularly women.
As the disease progresses, inflammation flakes can occur unpredictably and intermittently in optic nerves, brain, and spinal cord. Episodic symptoms, termed “relapses,” characterize the early relapsing remitting stage of MS (RRMS), during which irreversible CNS tissue injury accumulates, manifesting as progressive brain atrophy and eventually neurological disability, which is generally delayed for typically for 10-20 years after MS symptom onset.
During more advanced stages of MS, termed secondary progressive MS (SPMS), relapses occur less frequently or disappear entirely, but gradually worsening neurological disability ensues, and patients experience some combination of difficulty with walking, arm function, vision, or cognition—a process that can benefit from greater objective analysis.
Researchers at the Cleveland Clinic in Cleveland, Ohio, have determined that Apple’s iPad (and potentially other tablet computers that feature built-in technologies like accelerometers, gyroscopes, and touchscreens), when combined with appropriate software, can provide pretty good MS assessment capabilities.
Cleveland Clinic
The Cleveland Clinic research team reports how they’re using the iPad as a tool to perform an array of performance tests relevant to MS assessment in an Open Access study published in the Journal of Visualized Experiments (JoVE). For example, they explain that by attaching the iPad to a patient’s back while having her walk and balance, the app running provides precise data on posture.


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