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Disclaimer: 'MS Views and News' DOES NOT endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.
Overactive bladder is a problem with bladder-storage function that causes a sudden urge to urinate. The urge may be difficult to stop, and overactive bladder may lead to the involuntary loss of urine (incontinence).
If you have an overactive bladder, you may feel embarrassed, isolate yourself, or limit your work and social life. The good news is that a brief evaluation can determine whether there's a cause for your overactive bladder symptoms. Available treatments may greatly reduce or eliminate the symptoms and help you manage their effect on your daily life.
Signs and symptoms of overactive bladder may mean you:
Feel a sudden urge to urinate that's difficult to control
Experience urge incontinence — the involuntary loss of urine immediately following an urgent need to urinate
Urinate frequently, usually eight or more times in 24 hours
Awaken two or more times in the night to urinate (nocturia)
Although you may be able to get to the toilet in time when you sense an urge to urinate, unexpected frequent and nighttime urination can disrupt your life.
When to see a doctor
Overactive bladder isn't a normal part of aging. Treatments are available that might help you. It can be difficult to discuss such a private matter with your doctor, but it's important that you do — especially if your symptoms disrupt your work schedule, social interactions and everyday activities.
Evoked potential tests measure electrical activity in certain areas of the brain in response to sensory input. These tests are often used to assist in the diagnosis of multiple sclerosis, because they can indicate problems along the pathways of certain nerves that are too subtle to be noticed or found on a doctor's exam. Problems along the nerve pathways are a direct result of the disease. The demyelination causes the nerve impulses to be slowed, garbled, or halted altogether.
There are three main types of evoked potential tests:
Visual Evoked Potentials (VEP): You sit in front of a screen on which an alternating checkerboard pattern is displayed.
Brainstem Auditory Evoked Potentials (BAEP): You hear a series of clicks in each ear.
Sensory Evoked Potentials (SEP):Short electrical impulses are administered to an arm or leg.
A fourth type of test -- motor evoked potentials -- can detect lesions along motor pathways (those that produce movement) of the central nervous system. This test is not commonly used to diagnose MS.
While evoked potentials are used to help diagnose MS, other conditions can also produce abnormal test results, so the tests are not specific for MS. To accurately diagnose MS, the information the tests provide needs to be considered along with other lab tests and symptoms.
How Are the Evoked Potential Tests Performed?
Evoked potential tests are recorded by placing wires on the scalp over the areas of the brain that record the effects of stimulation on various parts of the body.
Previous research has indicated that salt may alter the autoimmune response, which is implicated in the development of multiple sclerosis (MS), but it is not clear if it has any direct effect on the course of the disease itself.
The researchers assessed the blood and urine samples of 70 people with the relapsing-remitting form of MS to check for levels of salt; a marker of inflammatory activity called creatinine; and vitamin D, low levels of which have been linked to the disease.
This group were asked to provide urine samples on three separate occasions over a period of nine months to monitor changes in dietary salt intake, and their neurological health was then tracked for two years, between 2010 and 2012.
By way of comparison, urinary salt levels were measured in a second group of 52 people with the same type of MS between June and July 2013.
Salt intake averaged just over 4 g per day in both groups, but ranged from under 2 g (low) to 2-4.8 g (moderate) to 4.8 g or more a day (high), with men tending to have a higher daily intake than women.
After taking account of influential factors, such as smoking, age, gender, length of time after diagnosis, weight, treatment and circulating vitamin D, the analysis indicated a link between levels of dietary salt and worsening symptoms.
Compared with those consuming the least salt every day, those on moderate to high intake in the first group had around three more episodes of worsening symptoms, and were almost four times as likely to have these episodes.
The researchers then looked at x-rays and scans to find out if the disease had progressed further, and once again found a link between dietary salt intake and radiological evidence of further deterioration.
Those whose dietary salt intake was high were almost 3.5 times as likely to have radiological signs of further progression.
Multiple sclerosis is a chronic, inflammatory medical condition that results in demyelination, axonal transection, and neurodegeneration. The myelin sheath is damaged because of an abnormal response by the immune system, which targets neurons within the central nervous system (CNS). It is a potentially debilitating disease in which the damage of the myelin sheath causes disruption in the communication and coordination functions of the body.
The symptoms of multiple sclerosis differ widely, subject to the extent of damage and the number of neurons affected. Some of the symptoms observed in a patient with multiple sclerosis are fatigue, numbness, spasticity, bladder dysfunction, cognitive changes, emotional changes, and depression. An individual with the severe course of the disease can experience speech problems and movement problems.
Multiple sclerosis can be broadly classified into four types: relapsing-remitting multiple sclerosis, secondary-progressive multiple sclerosis, primary-progressive multiple sclerosis, and progressive-relapsing multiple sclerosis. On the basis of the route of drug administration, the Global Multiple Sclerosis Drugs market can be segmented into two: Oral Drugs, and Parenteral Drugs.
The analysts forecast the Global Multiple Sclerosis Drugs market to grow at a CAGR of 5.56 percent over the period 2013-2018.
This report covers the present scenario and the growth prospects of the Global Multiple Sclerosis Drugs market for the period 2014-2018. To calculate the market size, the report considers the revenue generated from the sales of various drugs used for the treatment of multiple sclerosis.
When you have MS, your emotions are in play. While having MS raises your chances of having depression, knowing that fact -- and being aware -- can help you try to prevent it and get treatment. Protect yourself with healthy habits.
Get moving. When it comes to MS treatment, exercise is a two-for-one. Being active improves MS symptoms -- like fatigue and bladder problems -- and improves your mood, says Rosalind Kalb, PhD, vice president of clinical care at the National Multiple Sclerosis Society. "It's essential," she says.
Many people with MS say they feel better after walking, swimming, and biking. Before working out, talk to your doctor about what kind of exercise is good for you.
Relax. Kicking back in front of the TV likely isn’t enough. Try to relaxconsciously -- set aside time for it.
"I think it’s especially hard for people, especially women, to be in the moment," says Cindy Richman, senior director at the Multiple Sclerosis Association of America. "Yoga, meditation, mindfulness, and other approaches can help with that." Taking breaks works too, she says. “Read a few lines of a poem. Write in a journal. Go smell the flowers in your garden."
Get backup. You still have all the responsibilities you had before you got MS, but now you may not have the energy to tackle them all. That leads to stress.
Talk to your family and friends. Ask for help -- whether it's grocery shopping, picking up the kids after school, or making dinner. Talk to the people in your life before you're already feeling overwhelmed.
Taking care of yourself -- and preserving your resources -- isn't selfish. Lowering stress is good for your mental health, and that's good for your family.
Tackle issues one at a time. It's easy to get overwhelmed, especially when you’re having a challenging day. Stay in control by focusing on specific issues, and come up with solutions one at a time.
What would make your mornings easier? What household tasks are the most and the least important? Prioritize. "One success builds your confidence, and that leads you to the next," Kalb says.
Finding applies only to pot in pill or spray form, neurologists say
By Dennis Thompson
MONDAY, April 28, 2014 (HealthDay News) -- Medical marijuana can help relieve some symptoms of multiple sclerosis, but whether it can benefit patients with other neurological disorders is still unclear, according to a new review by top neurologists.
Doctors with the American Academy of Neurology reviewed current research and found certain forms of marijuana -- but not smoked marijuana -- can help treat MS symptoms such as muscle stiffness, certain types of pain and muscle spasms, and overactive bladder.
"There are receptors in the brain that respond to marijuana, and the locations of the receptors are in places where you would expect them to help with these symptoms," said Dr. Barbara Koppel, a professor of neurology at New York Medical College in New York City and a fellow of the American Academy of Neurology.
But marijuana can't help tremors caused by MS or involuntary muscle spasms caused by the use of levodopa to treat Parkinson's disease, the physicians concluded.
Their review included other neurological disorders such as Huntington's disease, Tourette syndrome and epilepsy, but the doctors found too little quality research to determine whether medical marijuana can help these conditions.
"We were frustrated that we couldn't say that it's good for this or bad for that. It's just a function of the lack of studies that were usable," Koppel said. "We see this review as a starting point for having more studies get done so we can review them down the road."
The academy's guideline development subcommittee presented the review Monday at the academy's annual meeting in Philadelphia, the world's largest gathering of neurologists. It also is published in the April 29 issue of Neurology.
The panel of experts looked at more than 1,700 study abstracts before focusing on 34 studies that dealt specifically with brain disorders.
Their findings recommend the use of medical marijuana for MS only if taken in pill or spray form, not by smoking it, Koppel said.
Converting marijuana to pill or spray form allows doctors to control the dose that patients receive of the drug's two medically helpful ingredients -- tetrahydrocannabinol, or THC, which gets a person high, and the nonpsychoactive component cannabidiol, or CBD.
The company has released a new version of the award-winning MS self™ App. Now available for free download on the App Store.
Irvine, CA (PRWEB) August 25, 2014
In partnership with Acorda Therapeutics, digital agency StudioPMG released Version 1.2 of the MS self App, a digital tool that may help those living with multiple sclerosis (MS).
The MS Mobile App won the 2014 Silver Communicator and the 2013 Platinum Marcom Consumer Application awards, and was recently updated. The MS Mobile App v1.2 is now available as a free download on the App Store.
“The purpose of this app is to help people proactively manage the daily challenges they face living with MS. The updated app adds some innovative and personalized features to make the experience more user friendly and focused”, said Rob Schrader, CEO of StudioPMG.
“The updated app includes Achievement Badges that users can earn by journaling and completing various functions. There’s even secret, hidden achievements needed to reach the ultimate MS self Champion status. Scoring Achievements make it a fun experience for the users while motivating them to get the most out of the app, ” said Joe McBride, EVP of Digital Solutions at StudioPMG.
This app gives those living with MS 24/7 access to fun, user-friendly tools and MS-related information. In addition, it can be easily synced with the user’s account and data between multiple iOS devices, allowing the user to set reminders, get notifications, and share with friends.
Researchers at Hofstra Northshore-LIJ School of Medicine have found the origins of the cell believed to cause multiple sclerosis (MS).
In a study published in Science Translational Medicine, researchers investigated B cells, a type of immune cell believed to be responsible for attacking brain tissue. In patients with MS, the immune system attacks the protective myelin covering the nerves. This damage disrupts communication between the brain and the rest of the body— ultimately leading to irreversible nerve deterioration.
B cells mutate as they migrate through the body’s tissues, which allowed researchers to determine the starting point.
“Our objective was to determine the origin and map the course of these cell abnormalities in the hope of targeting them for further investigations in MS treatment,” study author Joel N.H. Stern, an assistant professor of science education at the School of Medicine said in a press release.
Currently available MS treatments manage symptoms by using drugs that diffuse in the brain. Targeted treatments can be difficult and ineffective because of the brain’s protective barrier. The study of B cells may improve treatment efficacy.
“Since B cells travel in and out of the brain of MS patients repeatedly, our results reveal that it is possible to target these cells with drugs that diffuse in the blood, rather than the brain, making therapeutics for MS much easier to develop and we believe, more effective,” Stern said.
Additionally, researchers found that abnormal B cells found outside of the brain may provide a method of monitoring MS disease progression.
Strategies for myelin regeneration: Lessons learned from development
We would like to point out the importance of microglia/macrophagein remyelination. Except for serving as professional scavengers to clear up tissue debris (including disintegrated myelin and dead OLs), microglia are also play important role for OL development. The study group leaded by Prof. Yi Pang, University of Mississippi Medical Center , USA have demonstrated that microglia-conditioned culture medium not only provides strong support for OPCs' survival, but also greatly enhances their differentiation in vitro. Although activated microglia are notoriously known to be neurotoxic, recent studies suggest that this is not always the case. In MS, remyelination is great in areas where microglia are activated, while MS plaques lacking microglia/macrophage have poor remyelination. Nevertheless, the exact role of microglia in remyelination remains elusive, it is likely that their beneficial vs detrimental roles vary not only in different myelin diseases, but also depend on the timing of particular disease progression. This is sure to be an exciting area of research in myelination regenerative therapy. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 14, 2014).
Article: " Strategies for myelin regeneration: lessons learned from development" by Abhay Bhatt, Lir-Wan Fan, Yi Pang (Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS, USA)
Bhatt A, Fan LW, Pang Y. Strategies for myelin regeneration: lessons learned from development. Neural Regen Res. 2014;9(14):1347-1350.
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August 15, 2014 It was my privilege today to present a program for the Multiple Sclerosis Foundation (MSF) entitled “Building a Stronger MS community”. The focus of the program was to teach people to be their own Health Care Advocate by maximizing visit time with members of their Health Care Team. We also showed them how to find resources if their Health Care Plan drops a provider or medication on which they depend. Learning how to navigate the maze of Health Insurance language and restrictions, talk to your Physician or Congress person were topics that were addressed.
Watch for the Fall issue of MSFOCUS Magazine for highlights of this event. Some of the questions asked by attendees that I was able to address were:
· Can you explain how people present with and respond to treatment at various ages and stages in the disease process?
· Why aren’t we hearing more about Stem Cell Research?
· How do you get medication you need when it is on back order?
· How can you tell if you need a name brand drug instead of a Generic and is there any way to get it if you need it?
· Can you tell us more about how diet impacts MS (Dr. Terry Wahl and her Paleo-Diet was questioned….can a person really “cure MS” by eating like she does)?
· What are things that make MS worse that we can have some control over?
· Can you tell us about…? (LDN, Acupuncture, Ampyra, Vitamin D therapy, B-12 therapy and more)
· What is going on in research now and why can’t we get into trials? (directed to their Neurologist and www.clinicaltrials.gov). Folks were also made aware that they should not have to pay for their treatment in a valid Clinical trial and there was at least a 50% chance in most trials that they would NOT be on real medication but might be on placebo.
Thank you to the staff from MSF who flew from Florida to Rhode Island to offer this educational opportunity to people from RI and MA. It was a pleasure.
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TUESDAY, Aug. 26, 2014 (HealthDay News) -- An exercise component of the popular Nintendo Wii video game may help multiple sclerosis patients improve their balance by rewiring their brains, a new study suggests.
No medications exist to preserve balance in MS patients, and some drugs make balance worse, said study lead author Dr. Luca Prosperini, a neurologist at Sapienza University in Rome, Italy.
It appears that patients who use the Wii Balance Board five days a week -- moving to snowboarding or dance games, for example -- may help reduce their risk of falls and boost certain brain connections, possibly because they're coordinating their movements with a figure on a screen, Prosperini said.
There are caveats to the research, however. The study was small, and there's a risk that patients could hurt themselves by falling, although they can play seated rather than stand on the balance board.
"Patients with MS should be encouraged to start using this system only under supervision," Prosperini said. "Once well-trained, they may use it at home."
Multiple sclerosis is a nerve disorder that affects how the brain communicates with the body.
"Balance problems are quite common and arise due to the effects of MS on a number of functions that are important for balance," said Nicholas LaRocca, vice president for health care delivery and policy research with the National Multiple Sclerosis Society. Among other things, MS can disrupt vision, coordination and the body's balancing mechanism, he said.
Patients turn to a variety of strategies to support balance, he said. Canes and orthotic devices (shoe inserts) help some people, and rehabilitation can build strength and coordination. Some patients try electrical muscle stimulation to maintain or regain control of their muscles, he said.
Prosperini was inspired to study a video game treatment for MS when he saw patients in rehabilitation using a balance-boosting system that reminded him of an old Atari video game. Then a commercial about the Wii Balance Board caught his attention. The balance board, shaped a bit like a weight scale, detects a person's movements and allows them to be translated into action on a TV screen.
Prosperini tried to get a grant from Nintendo to support research. The company wasn't interested, he said, but he obtained funding from the Italian MS Society.
His previous research has supported the idea that patients regain balance when they use the Wii Balance Board. The new study aimed to understand what's happening in their brains.
In the new study, published online Aug. 26 in Radiology, 27 MS patients were split into two groups. One group spent three months doing nothing special while the other group played with the Wii Balance Board for 30 to 40 minutes daily, five days a week. Then the groups reversed roles: Those who had done nothing special used the balance board for three months, while the others stopped using it.
Another 15 healthy people tried the system, too.
All participants had specialized MRI scans to detect any physiological changes in the brain.
The Pharmaceutical Management Agency(PHARMAC) is considering a funding proposal that includes five treatments for multiple sclerosis (MS), namely two key MS drugs, Biogen‘sTysabri and Novartis‘ Gilenya, that are not currently funded. PHARMAC is the New ZealandCrown agency that decides, on behalf of District Health Boards, which medicines and related products are subsidized, which means that natalizumab and fingolimod may start to be prescribed by the New Zealand community and public hospitals. Continue
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tried and continue to use the CanChew chewing gum product which contains hemp
oil. It was recommended to me by more than one individual as an aid for
After conferring with my neurology specialist, I decided to
begin a prescription medication, Baclofen, at approximately the same time. I
use the prescription medication only 2 times per day, morning and night, rather
than 3 times per day as suggested.
I use the CanChew gum mid-day. I have
noticed a definite reduction in the spasticity of my legs throughout the day
and night. I will credit my improvement to both the prescription medication and
the CanChew gum product. Either alone may have been beneficial, but both
in combination seem to be working well for me and I will continue this regime.
provided by: Anonymous ================================ For those with interest, CanChew is available through Amazon.com Remember if purchasing anything from Amazon, to use their newest link: www.amazonsmiles.com and add THIS charity name: MS Views and News, as your charity of choice.