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Saturday, February 20, 2016
INFORMS Published: Fingolimod Fails in Primary Progressive MS
February 19, 2016
Full details of the INFORMS trial have confirmed that the multiple sclerosis (MS) drug fingolimod did not slow progression of disability or brain volume loss vs placebo in the primary progressive form of the disease.
The trial results have now been published online in The LancetJanuary 27, with lead author Fred Lublin, MD, The Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Icahn School of Medicine at Mount Sinai, New York, New York. Top-line results were announced previously by Novartis.
In the Lancet paper, Professor Lublin and colleagues note that fingolimod did show an anti-inflammatory effect in the INFORMS trial, significantly reducing the numbers of gadolinium-enhancing and new T2 lesions on brain MRI. However, unlike the situation with fingolimod in relapsing-remitting MS, this had little effect on the process that leads to brain volume loss and disability progression in the primary-progressive MS population.
They conclude that: "The results of INFORMS suggest that anti-inflammatory strategies applied at present in relapse-onset multiple sclerosis are unlikely to be beneficial in primary progressive multiple sclerosis, and that novel approaches might be needed to treat patients with primary progressive multiple sclerosis.
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