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Thursday, March 10, 2016

Physical Activity in Pediatric Multiple Sclerosis— Can Lifestyle Factors Affect Disease Outcomes?

E Ann Yeh, Robert W Motl
US Neurology, 2015;11(1):19–22 DOI:

Abstract: Currently, little to no information is available about interventions that can ameliorate symptoms such as depression and fatigue in children and adolescents with multiple sclerosis (MS), nor is there clear information on modifiable factors that can provide neuroprotection in this population. However, physical activity (PA) may have significant effects on disease activity, future disability, cognition, and symptoms of depression and fatigue in pediatric MS. The extent of this effect is unknown. In this paper, after providing an overview of definitions of and outcomes in pediatric MS, we provide a review of existing literature relating PA to outcomes in MS, and then turn to a review of the complex relationship between PA, neuroinflammation, and outcomes in the pediatric population.

Keywords: Pediatric, multiple sclerosis, physical activity, outcome, fatigue, depression, exercise, review

Disclosure: E Ann Yeh receives funding from the National MS Society, the Canadian Institutes of Health Research, the Dairy Farmers of Ontario, SickKids Foundation, SickKids Innovation Fund, Canadian Multiple Sclerosis Monitoring System/Public Health Agency of Canada (CMSMS/PHAC), the Canadian Multiple Sclerosis Scientific Research Foundation, and the MS Society of Canada. Robert Motl has received speaker honoraria from EMD Serono. No funding was received for the publication of this article.
Received: January 26, 2015 Accepted March 06, 2015

Correspondence: E Ann Yeh, Division of Neurology, Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5B 1X8 Canada. E:

Open Access: This article is published under the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, adaptation, and reproduction provided the original author(s) and source are given appropriate credit.

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