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Thursday, March 17, 2016

Undetected disease activity may increase MS patients' risk of disability

In MS, clinical and subclinical disease activity can occur early in the disease course and persist throughout the disease.1-3
Emerging scientific research shows that a considerable amount of disease activity may elude detection4
See research about lesion detection >
Even small amounts of subclinical or clinical disease activity can be predictive of future disability, and can result in permanent damage2,5
Review the impact of disease activity on disability >
Genentech. A Member of the Roche Group.
Shining a Light on Multiple Sclerosis.
Polman CH, Reingold SC, Banwell, B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011(2);69:292-302.
Scott TF, Hackett CT, Quigley MR, Schramke CJ. Relapsing multiple sclerosis patients treated with disease modifying therapy exhibit highly variable disease progression: a predictive model. Clin Neurol. 2014(127);86-92.
Prosperini L, Gallo V, Petsas N, Borriello G, Pozzilli C. One-year MRI scan predicts clinical response to interferon beta in multiple sclerosis. Eur J Neurol. 2009;16(11):1202-1209.
de Graaf WL, Kilsdonk ID, Lopez-Soriano A, et al. Clinical application of multi-contrast 7-T MR imaging in multiple sclerosis: increased lesion detection compared to 3 T confined to grey matter. Eur Radiol. 2013;23(2):528-540.
Rio J, Nos C, Tintoré M, et al. Assessment of different treatment failure criteria in a cohort of relapsing–remitting multiple sclerosis patients treated with interferon β: implications for clinical trials. Ann Neurol. 2002;52(4):400-406.

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