MS Views and News Be empowered with MS views and news. To receive The MS BEACON e-Newsletter, CLICK HERE - -

Visit our MS learning channel on YouTube, which provides hundreds of MS educational videos presented by MS Experts from across the USA. Archived here: www.youtube.com/msviewsandnews -- Also please visit our Social media platforms: Facebook, Twitter, and Instagram . Each providing important information for the MS community. Furthermore, scroll down the left side of this blog to learn from the resources and links.

Disclaimer: 'MS Views and News' DOES NOT endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, for your personal knowledge and to keep you informed of current health-related issues. It is not a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


Monday, July 4, 2016

MS Progression May Be Tied to Workings of Immune Complement System in Brain Lesions


                                                                  
  



 




The complement system, a part of our non-adaptable (innate) immune defenses, is activated in lesions inside the brain’s gray matter and may well contribute to the relentless progression of multiple sclerosis (MS), researchers report. The findings offer new insights into mechanisms driving the development of this disease — particularly its primary progressive forms.
The complement system is composed of an array of proteins that, by triggering a cascade of molecular signals, enhances (complements) the activity of other parts of the immune system, including antibodies and cells that clear microbes and cell debris.
High levels of complement system factors are found in blood and cerebrospinal fluid of MS patients, suggesting that the system is actively contributing to disease. But precisely how it contributes is not at all clear. Earlier studies have shown that — in contrast to brain lesions in the myelinated white matter of the brain — increased numbers of lesions in the gray matter predicts disease course.
During brain development, the complement system is needed for synaptic pruning, a process whereby excessive brain connections are eliminated, making researchers suspect that the same mechanisms might be involved in neurodegeneration in MS. A few studies have confirmed this by showing the presence of certain activated complement factors, along with a lack of molecules controlling them, in brain areas marked by nerve cell death. So far, however, no studies have done more extensive screening of complement factors in the brains of MS patients.





MS Views and News
Providing educational information, resources and services for those affected by MS





No comments: