Please visit our MS learning channel on Youtube, which provides hundreds of topics from our education programs, that were video-recorded and archived here: www.youtube.com/msviewsandnews

joomla ecommerce template -- Scroll left side of this blog for needed resources. Also, use our 'search by topic' tool, to find specific information.

Disclaimer: 'MS Views and News' DOES NOT endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.

=================

CHAMPIONS TACKLING MS - AWARDS Dinner, Honoring Aaron Boster, MD and Jon e. Glaser, DDS - now open for registration. Visit www.events.msvn.org

Tuesday, October 4, 2016

Pair of proteins found to drive neuroinflammation


                                                                  
  

Study could pave way for development of novel therapeutic approaches for inflammatory diseases


Click here to receive MS news via e-mail

PUBLISHED: 11OCT2016
McGill researchers have identified two proteins that work together to drive neuroinflammation in acute conditions such as microbial or autoimmune encephalitis, and in chronic conditions such as multiple sclerosis. 
In a study published today in Nature Immunology, a team led by Prof. Philippe Gros show that genetic inactivation of this protein pair blocks neuroinflammation and prevents the appearance of disease in animal models of multiple sclerosis (MS). The findings could pave the way for development of novel therapeutic approaches in inflammatory diseases such as MS. 
The study involved a close collaboration among scientists at the McGill Research Centre on Complex Traits, the Montreal Neurological Institute, and the McGill University and Génome Québec Innovation Centre. The researchers found that the pair of proteins -- a deubiquitination enzyme USP15 and a ubiquitin ligase TRIM25 -- appears active both in resident brain cells, such as microglia and astrocytes, and in immune cells that can infiltrate the brain and spinal cord during neuroinflammation. The results indicate that USP15/TRIM25 system regulates a critical pro-inflammatory pathway, known as type I interferon, that initiates and amplifies neuroinflammation. 




MS Views and News
Providing educational information, resources and services for those affected by MS

No comments: