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Monday, December 19, 2016

Lack of natalizumab concentration increase before PML argues against extending dosing interval


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Publish date: December 14, 2016
By: Jeff Evans  Frontline Medical News

Key clinical point: Extending the dosing interval of natalizumab to a maximum of 8 weeks in order to lower its serum concentration may not do anything to reduce the risk of PML.

Major finding: A total of 10 control patients had a mean natalizumab serum concentration of 23.8 mcg/mL, which was in the same range as the 18.9 mcg/mL level observed in 5 patients before a diagnosis of PML.

Data source: A comparison of 5 patients with PML and 10 age- and sex-matched controls from a prospective cohort of 219 patients with relapsing-remitting MS who were treated with natalizumab at one center.

Disclosures: The study received support from the Brain Foundation Netherlands. Five of the authors reported financial ties to various pharmaceutical companies that market MS drugs, including Biogen, which markets natalizumab.

Read complete article here

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