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Saturday, April 16, 2016

Teva to Present Pipeline Data on MS Treatments at Ongoing AAN Annual Meeting

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Teva Pharmaceutical Industries, Ltd., announced that new data on four of its products, including an approved and a potential treatment for multiple sclerosis, will be presented at the 68th Annual Meeting of the American Academy of Neurology (AAN), running through April 21 in Vancouver, Canada.
The data, to be given in multiple posters and three platform presentations, will cover the products:
  • Copaxone (glatiramer acetate injection), a synthetic protein that simulates myelin basic protein, a component of the myelin sheath that insulates nerve fibers in the brain and spinal cord. This drug seems to block myelin-damaging T-cells, although the mechanism is not completely understood. Copaxone is U.S. Food and Drug Administration (FDA)-approved for the treatment of relapsing forms of multiple sclerosis (RMS).
  • Laquinimod, an experimental immunomodulator being developed for relapsing and progressive forms of MS.
  • SD-809 (deutetrabenazine), a small molecule inhibitor of vesicular monoamine 2 transporter, or VMAT2, that is designed to regulate the levels of a specific neurotransmitter in the brain called dopamine. It is being developed for chorea associated with Huntington’s disease, and for tics associated with Tourette syndrome.
  • TEV-48125, an investigational anti-calcitonin gene-related peptide (CGRP) monoclonal antibody, being developed for the prevention of chronic and high-frequency migraines (migraine with headaches on at least 15 days per month).
According to a press release, specific Teva-sponsored data to be presented include:   - click here to continue reading 



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Teva gets patent for invention related to multiple sclerosis drug

April 16, 2016

The company claims that the pharmaceutical composition in the product, related to multiple sclerosis drug Laquinimod, provides superior stabilisation


Israel-based Pharmaceuticals has received approval for a product related to drug Laquinimod. According to reports, is developed by Teva Pharma in collaboration with AB, a Swedish biotechnology company which has focus on neurodegenerative/ inflammatory diseases and cancer.
According to Active Biotech, laquinimod is a compound under development for the treatment of multiple sclerosis and Huntington's disease and the company has an agreement with Teva covering the development and commercialisation of the drug.




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Stem Cells Show Reversal of Disability in Multiple Sclerosis at the American Academy of Neurology (AAN) 2016 Annual Meeting

MS Patients Take Steps without Cane as Damage is Repaired
New York, NY (PRWEB) April 15, 2016
Dr. Saud A. Sadiq, Director and Chief Research Scientist at the Tisch MS Research Center of New York (Tisch MSRCNY) will be presenting on Tuesday, April 19, 2016, the extraordinary results from his FDA-approved stem cell clinical trial for MS at the American Academy of Neurology’s 68th Annual Meeting in Vancouver, BC, Canada. Dr. Sadiq will deliver the highly anticipated news during a session titled“Remyelination and Repair in Multiple Sclerosis (MS) Data Blitz Presentations.”
The presentation reveals data from the Phase I trial showing that the novel stem cell treatment was safe and well-tolerated with no serious adverse events reported. What’s more, the cutting-edge protocol of this trial created at Tisch MSRCNY allowed for the delivery of brain-like neural cells within 30 minutes of harvesting, a technique not seen anywhere else in the world.
“Repair and regeneration is possible. We have a patient who no longer needs her cane, one who has transitioned from a motorized scooter to taking steps with a walker and another who has discontinued their bladder medication as those symptoms have dramatically improved. This is the first treatment that improves established disability in patients with progressive MS and shows us there is hope that a future treatment is possible,”
stated Dr. Saud A. Sadiq.
Due to these unprecedented results, the FDA has already advised Tisch MSRCNY to begin preparations for Phase II of this important trial to establish efficacy of stem cells as a reparative therapy. This is expected to commence at the end of 2016, once funding is secured.



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Friday, April 15, 2016

Urinary Tract Symptoms Found to Affect 70% of MS Patients in Study and Contribute to Disability

Urinary tract symptoms affect a large proportion of patients with multiple sclerosis (MS), yet their extent and type is not well-known. A study reported that among a cohort of people with the disease, almost 70 percent had urinary tract problems, adding to the extent of their disability.
Researchers at Capital Medical University in Beijing enrolled 126 MS patients — a group composed of 30 people with clinically isolated syndrome (CIS), 64 with relapsing-remitting MS (RRMS), 10 with primary progressive MS (PPMS), and 22 with secondary progressive MS (SPMS).
In this sample, 67.5 percent had lower urinary tract symptoms, most frequently in the form of urgency to urinate. The most common urological abnormality was an overactive bladder muscle, likely the main cause of feelings of urgency as 71.6 percent of patients with urgency also had an overactive bladder. Other common symptoms were frequent urination, urge incontinence, and stress incontinence.
Urological symptoms were associated with more severe disability, as assessed by the expanded disability status scale (EDSS). Particularly, a scale measuring the severity of overactive bladder indicated that the greater the bladder symptoms, the higher the disability.

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Alternative Medicine and Complementary Care for MS

Alternative and complementary treatments can help with MS symptoms like pain, stiffness, and muscle spasms. Research is still new, so they haven't been fully tested yet. But many people say they get relief from them.


Acupuncture

In this therapy, a professional inserts thin needles into specific points in your body.
Does it work? "We don't have a lot of data," says Matthew McCoyd, MD, a neurologist and MS specialist at Loyola University Medical Center. Doctors need to study more people with MS who use acupuncture to know for sure.
Some small studies have found that acupuncture can ease pain, muscle spasms, numbness, tingling, bladder problems, and depression.
Although it may help your symptoms, there's no evidence that it reduces how often you get MS flare-ups or slows the disease.
Is it safe? It generally is when you get it from a well-trained, licensed professional.


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Gotta Go - Gotta GO --- Tame Your Bladder When You Have MS

Take charge of your "urge to go" by trying some simple tips.
Don't sip. Drink a small glass of water (about 6 to 8 ounces) all at once every few hours during the day. That's better than sipping drinks constantly, which might give you the urge to pee more often. You'll know when you get enough to drink because your urine will turn light yellow.
Stop drinking before bed. Stay hydrated, but don't drink too close to bedtime or you could wake up during the night to use the bathroom. Have your last drink of water or other fluid at least 2 hours before you go to bed.
Limit caffeine and alcohol. Cut back on coffee, soda, beer, and wine. Caffeine and alcohol can irritate your bladder and increase the urge to go. Alcohol also affects the way your kidneys absorb water, and it can make your bladder fill up more quickly than usual.
Don't smoke. Nicotine is another bladder irritant. If you smoke, ask your doctor for advice on nicotine replacement products, medicines, and other methods to help you quit.
Do Kegel exercises. Just like you tone your biceps and triceps, you can strengthen the pelvic floor muscles that support your bladder. These muscles hold urine in your bladder so it won't leak when you sneeze, cough, or laugh.
To find the right muscles, squeeze like you would to stop the flow of urine, hold for about 4 seconds, then release. Do these exercises a few times each hour. You don't have to set aside a special place or time. Do them wherever and whenever you like.
Continue this interesting read from WebMD





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Could I Have MS or Something Else?

Maybe you’ve felt exhausted or weak lately. Or your foot is starting to tingle. So you do a quick Internet search and come up with an alarming result: Your symptom is one of the signs of multiple sclerosis (MS), a disease of the brain and spinal cord.
Before you start to worry, know that many signs of the condition are the same as symptoms of other health problems. So it’s easy to mistake another issue for MS, which affects less than 1% of Americans.
How can you tell if what you’re feeling is caused by MS or something else? First, keep in mind that most people have the first signs of the disease between the ages of 20 and 40. You can also keep track of your problems: MS symptoms tend to come and go or get worse over time.
It helps to know what else can explain some of the signs you might be feeling.

Numbness or Tingling

A lack of feeling or a pins-and-needles sensation can be the first sign of the nerve damage from MS. It usually happens in the face, arms, or legs, and on one side of the body. It also tends to go away on its own.
Numbness and tingling can also come from a lack of blood flow or apinched nerve, so think first if you slept in a funny position or sat without moving for a long time. Other conditions can lead to nerve damage, too: Carpal tunnel syndrome affects the wrist, while diabetic neuropathy can trigger numbness, tingling, or pain in the feet or hands.
Sudden numbness on one side of the body may signal a stroke. If that happens to you, call 911 ASAP.

Dizziness

Is the room spinning? MS can make you feel lightheaded or off-balance, usually when you’re standing up and moving around.
If you’re dizzy and nauseous when you’re lying down, or if you stumble to one side, chances are it’s a problem with your inner ear, which controls your balance. Medications, such as those for depression and seizure disorders, can cause similar problems, too.
Did a quick wave of lightheadedness hit? That’s often a sign of low blood sugardehydration, or a sudden drop in blood pressure you get when you stand up quickly. You may need to slowly rise instead of hopping to your feet.

Click below to continue from WebMD
1 | 2 | 3 





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Allergy Med May Reverse MS Vision Loss

Vision improvement with clemastine fumarate appears modest but results are promising, researcher says

WebMD News from HealthDay
By Robert Preidt
HealthDay Reporter
TUESDAY, April 12, 2016 (HealthDay News) -- An over-the-counterantihistamine used to fight allergies may have an important new role: reversing the vision loss sometimes caused by multiple sclerosis.
That's the finding from preliminary research that found that clemastinefumarate partially reversed optic neuropathy in people with MS.
Optic neuropathy is damage to the nerve that relays information from the eye to the brain.
The study is to be presented April 19 at the American Academy of Neurology's annual meeting in Vancouver.
"While the improvement in vision appears modest, this study is promising because it is the first time a drug has been shown to possibly reverse the damage done by MS," said study author Dr. Ari Green, assistant clinical director of the Multiple Sclerosis Center at the University of California, San Francisco.
The study was small, involving only 50 people averaging 40 years of age. All had been diagnosed with MS for an average of five years and were also diagnosed with optic neuropathy.
For three months, patients received either the antihistamine or aplacebo. The groups were then switched for the last two months of the study.
While taking the antihistamine, patients showed a slight improvement in terms of the delays in time it took for visual information to travel from the eye to the brain, Green's team said.





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What Having Multiple Sclerosis Feels Like

news_11_Artboard 343 copy 38


Since the central nervous system (CNS) is affected in MS, all of the organs which are controlled by the CNS are affected by the disease at different points of time within its progression.
The most common multiple sclerosis symptoms include:
1 – Fatigue   - 
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In this video meet Veronique, a yoga instructor who demonstrates a “Yoga for Multiple Sclerosis Seated Warm-up Sequence”.

In this video meet Veronique, a yoga instructor who demonstrates a “Yoga for Multiple Sclerosis Seated Warm-up Sequence”.

Learn more about multiple sclerosis here: http://bit.ly/1jAzZpz





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Multiple Sclerosis: anti-LINGO-1 for Test Vision and promoting remylenation


MARCH 24, 2016 -  BY MARTA RIBEIRO 



Neuro-ophthalmologist Tariq Bhatti, MD, at Duke University Eye Center, discusses the use of optical coherence tomography (OCT) in evaluating multiple sclerosis progression and the effects of treatments – namely anti-LINGO-1.

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Multiple Sclerosis Documentary: MS Doesn’t Define Who I Am - short movie

Published on Jul 8, 2014 - Multiple Sclerosis Documentary from Bahrain




In this documentary from 2014 made by multiplesclerosisinbahrain, learn how MS patients feel about their multiple sclerosis diagnosis, about their treatment, and how they cope with the disease.

Published on Jul 8, 2014
HOW THE MULTIPLE SCLEROSIS PATIENTS FEEL UPON BEING DIAGNOSED AS MS AND DURING TREATMENT


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10 Tips for Self-Managing Your Multiple Sclerosis

MARCH 23, 2016 - BY MARTA RIBEIRO 

10 tips managing multipleSclerosis


1. Get plenty of good restshutterstock_225635005
Everybody functions better after a good night sleep. Getting some good rest is even more important to someone who suffers from multiple sclerosis. So to improve your lifestyle, try sleeping at least 8 hours a night.
2. Exercise
shutterstock_360001196
Regular, moderate and simple exercise is a great way to improve your strength, balance,  muscle tone and co-ordination while living with multiple sclerosis. If your body temperature is too high and you feel uncomfortable with it, swimming and other water activities involving exercise can be a good option to help you get your temperature back to normal again.
If your MS is limiting you, try some simple exercises like walking, yoga, tai-chi, stretching and stationary bicycling.


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