Please visit our MS learning channel on YouTube, which provides hundreds of MS related topics from many of our video recorded education programs and archived here: -- Be empowered with MS views and news. Opt-in with us:

~~ Scroll left side of this blog for needed resources. Also, use our 'search by topic' tool, to find specific information.

Disclaimer: 'MS Views and News' DOES NOT endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.


Tuesday, April 4, 2017

Gene interaction tied to risk of developing multiple sclerosis

Click here to receive MS news via e-mail

By Nathan Luzum | Monday, April 3

thinkstockphotos179062209 Courtesy of Duke Photography

Variations in two genes could significantly increase the odds of developing multiple sclerosis, according to a new study by a team of Duke researchers.
The scientists discovered a new interaction between a gene called IL7R—which past studies have demonstrated contributes to the likelihood of developing MS—and a gene that plays an important role in regulating it, called DDX39B. They hypothesized that a variation in these genes would produce a different protein—one more likely to cause MS.
“If you happen to be an individual that has the variants of both genes, you have a much higher chance of developing MS,” said Mariano Garcia-Blanco, co-lead author of the study and chair of the department of molecular biology and biochemistry at the University of Texas Medical Branch at Galveston.
Garcia-Blanco explained that the study's research focused on controlling the expression of "soluble IL7R," or the soluble form of a receptor that is important in activating the immune cells causing the neural damage associated with MS. 
The difference between soluble IL7R and the standard IL7R protein is a portion of a gene known as an exon, which is the sequence of a gene's DNA that contains information about the coding for a protein sequence. Garcia-Blanco explained that the same gene could produce multiple versions of a protein in a process known as alternative splicing.
“What alternative splicing does is akin to what an editor in the film industry can do,” he said.

MS Views and News is MAKING an IMPACT on those affected by Multiple Sclerosis

No comments: