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Thursday, June 8, 2017

Physical Activity and Healthy Aging with Multiple Sclerosis— Literature Review and Research Directions

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US Neurology, 2016;12(1):29–33 DOI:


 There is a “greying” of the population of persons with multiple sclerosis (MS) that coincides with both increased life expectancy and the shifting demographic landscape worldwide. This growing cohort of older adults with MS undergoes normal age-related declines in physical and psychologic functioning that may be compounded by the disease and its progression. Little is known about predicting and managing the progression and consequences of MS in older adults. We believe that a focus on physical activity behavior represents a novel opportunity for transformative research on healthy aging with MS. The current paper reviews existing evidence on physical activity rates, correlates, consequences, and interventions among older adults with MS, and highlights important areas for future research on physical activity and health aging with MS.
Keywords: Aging, exercise, multiple sclerosis, physical activity, sedentary behavior
Disclosure: Robert W Motl, PhD, receives research funding from Biogen Idec and Acorda Therapeutics, and provides speaking engagements for EMD Serono. Emerson Sebastião, PhD, Rachel E Klaren, BS, Edward McAuley, PhD, Elizabeth AL Stine-Morrow, PhD, and Brent Roberts, PhD, have no conflicts of interest to declare in relation to this article.
Received: November 16, 2015 Accepted November 30, 2015
Correspondence: Robert W Motl, PhD, 906 S Goodwin Ave, Urbana, IL, 61801, US. E:
Support: The writing of this paper was supported by a mentor-based postdoctoral fellowship from the National Multiple Sclerosis Society (MB 0029).
Open Access: This article is published under the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, adaptation, and reproduction provided the original author(s) and source are given appropriate credit.
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