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Saturday, August 11, 2018

TG Therapeutics Reaches Target Enrollment in Phase 3 Trials to Test Ublituximab in Relapsing MS


ublituximab

TG Therapeutics announced it has reached target enrollment in the ULTIMATE I and II Phase 3 clinical trials assessing the use of ublituximab (TG-1101) to treat relapsing forms of multiple sclerosis (MS). Ublituximab is a modified anti-CD20 monoclonal antibody, which is designed to target a protein present on mature B-cells, which are immune cells involved in […]

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Hair Loss Seen in RRMS Patients Using Aubagio Often Temporary and Mild, Study Says


hair thinning, AubagioHair thinning in relapsing-remitting multiple sclerosis (RRMS) patients using Aubagio is usually mild and temporary, and does not require stopping treatment, a small real-world study reports. The research, “Real-World Observational Evaluation of Hair Thinning in Patients with Multiple Sclerosis Receiving Teriflunomide: Is It an Issue in Clinical Practice?,” was published in the journal Neurology and Therapy. MS […]

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Friday, August 10, 2018

SIZE Does Matter --- Magnetic resonance imaging (MRI) is the key prognostic tool in people with a clinically isolated syndrome

Size and Location (of MRI spots) matter! "Magnetic resonance imaging as a prognostic disability marker in clinically isolated syndrome: A systematic review"
Provided by Aaron Boster, MD


Abstract

Magnetic resonance imaging (MRI) is the key prognostic tool in people with a clinically isolated syndrome (CIS). There is increasing interest in treating people following a CIS in the hope that conversion to multiple sclerosis (MS) will be prevented and future disability reduced. So far, the prognostic value of MRI for disability following a CIS has not been evaluated systematically. We systematically searched MEDLINE and EMBASE. Cohort studies were selected if they reported associations of MRI and disability following a CIS, included at least 50 people with a CIS at baseline, had at least 5 years of follow-up and obtained at least one structural MRI measurement (T1 lesions, T2 lesions, T1 contrast enhancing lesions or brain atrophy). We assessed the studies for quality and rated the completeness of MRI reporting. In total, 13 studies were identified reporting on the following: T2 lesion number and volume, T2 infratentorial lesion number and volume, T1 contrast enhancing lesions and grey matter fraction. T2 brain lesion number determined soon after the occurrence of a CIS was associated with disability progression after 5 - 7 years, with an increased risk when 10 or more lesions were present. Infratentorial lesions were also associated with a higher risk of subsequent disability. The number and distribution of MRI-visible lesions soon after a CIS is associated with disability later on, and may offer additional useful information when making treatment decisions in people with early MS. Further work is required to determine if other measures have a higher predictive potential. This article is protected by copyright. All rights reserved.

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Video: The MS Improvement Project: Update Summer 2018

Did you know that some MS patients manifest IMPROVEMENTS to disability? It’s true, and I’m amazed that no one seems to talk about it. Well, we’re going to talk about it in this video!
In the modern era of 2018, with our highly effective disease modifying therapies, we now see increasing numbers of patients (upwards of 41% of patients in some clinical trials) who manifest “confirmed disability improvements” or CDI (link: https://youtu.be/TYvdnulc1Sk). CDI is defined as IMPROVING on the disability scale we use in MS (called the expanded disability status scale, or EDSS) by at least 1 point and maintained for at least 6 months. WOW!
Several symptomatic therapies IMPROVE functional outcomes in MS. In the 1st MS Improvements Project video (link: https://youtu.be/_tWRMuPjaz0), I talked about how symptomatic treatments for heat sensitivity and motor fatigue, pathologic fatigue and cognitive impairments, severe spasticity and depression. There is evidence amongst all these treatment that they can improved function in some patients.
In this Video, “The Improvement Project: Update Summer 2018” I share several real-life anecdotes of meaningful improvements amongst people with MS. I discuss improvements to cog fog, pathologic fatigue, fecal incontinence, neuropathic pain, comprehension of social cues, imbalance, bladder dysfunction and more. Please note that I’ve changed aspects of the stories to ensure patient privacy.)


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Thursday, August 9, 2018

Help us to help those with Multiple Sclerosis in Rural America

Dear Friends: The organization which I founded (MS Views and News) is trying hard to make a difference to those living with / affected by Multiple Sclerosis (MS) in Rural America, Help us to bring educational programs to underserved areas with great need. Thousands with Multiple Sclerosis, live in areas where MS educational programs have never been held. Please Give to our Rural America fund by clicking here: https://goo.gl/caGhxN These thousands of individuals often do not even know of the latest and newest MS medications, therapies and treatments which can possibly keep them 'moving'.. People in Rural America need to be provided with MS educational programs. This is why We Need YOUR help. -- Please click the link showing above and give whatever you can, to help us, help others.. - All contributions are tax deductible to fullest extent allowed by law ~~~ Thank you ~~~

Tuesday, August 7, 2018

Help us to Provide Needed MS educational information to underserved communities in the USA

This message will enable us to provide MS educational programs in various Rural areas of the USA that need the information we provide. Help us to serve those in underserved communities - Thank you ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ >>> DO YOU SHOP ON AMAZON? <<<< Help support our project to bring Multiple Sclerosis information, education and resources to Rural America (underserved areas) When you do your shopping at AmazonSmile, -- Amazon donates 0.5% of the purchase price to MS Views And News. Bookmark the link http://smile.amazon.com/ch/26-3323427 and support us every time you shop. PLEASE Shop at AMAZONSMILES - http://smile.amazon.com/ch/26-3323427 Select MS Views and News as your choice of Charity

Sunday, August 5, 2018

Factors that Worsen MS Cognition

Boster's MS Corner:

Cognitive impairment is seen in over half of people with multiple sclerosis. In this video I review factors that can contribute to multiple sclerosis brain fog, ways to assess cognition, and tips to improve thinking and memory. If you have questions related to Multiple Sclerosis memory loss and other MS cognitive issues, then start watching this video! In this video, I review factors that can worsen cognition in MS, 3 helpful ways to assess cognition in MS, and 6 easy tips to immediately optimize your thinking and memory!





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Rare and Unusual MS Symptoms (Aaron Boster, MD , has seen in clinic)

Aaron Boster, MD : In this video I share the most rare and uncommon Multiple Sclerosis symptoms I've seen in over a decade and a half of clinical practice. Want to hear about the 8 most unusual MS symptoms I've seen, then start watching this video RIGHT NOW!



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