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Friday, April 11, 2008

About BHT-3009 an Investigational Product for Multiple Sclerosis

Bayhill Therapeutics
April 10, 2008 08:44 PM Eastern Daylight Time

Bayhill Therapeutics Announces Presentation of MS Drug Candidate
BHT-3009 at American Academy of Neurology 60th Annual Meeting

PALO ALTO, Calif.--(BUSINESS WIRE)--Bayhill Therapeutics, Inc., a clinical-stage biopharmaceutical company leveraging its proprietary therapeutic BHT-DNA™ platform to develop novel and targeted autoimmune disease treatment candidates, today announced that the Company’s co-founder and Vice President of Research, Hideki Garren, M.D., Ph.D., will present at the American Academy of Neurology 60th Annual Meeting (AAN) in Chicago. Dr. Garren’s podium presentation will discuss Bayhill’s lead product candidate BHT-3009 in relation to an abstract (#857) entitled “Results from a Phase 2 Trial of a Myelin Basic Protein Encoding DNA Vaccine for Relapsing Multiple Sclerosis" at session S22: “Multiple Sclerosis: Clinical Trials III” on Wednesday, April 16 at 2:30 PM central time at McCormick Place West Convention Center, Chicago, IL.

» Read More

Thursday, April 10, 2008

Increasing positive experiences decreases depression symptoms in patients with multiple sclerosis

Published: Wednesday, 9-Apr-2008

Medical Studies/Trials

Depression is prevalent among people living with chronic diseases, such as multiple sclerosis (MS). Although most people with MS live normal lives, they must manage symptoms and treatments that cause increased emotional and psychological stress on a daily basis.

Now, researchers from two universities have found that people with MS who increase positive experiences decrease their symptoms of depression and improve the overall quality of their lives.

» Read More

What is Myelin?

Myelin is the insulating sheath surrounding nerve cells…the white matter coating our nerves, enabling them to conduct impulses between the brain and other parts of the body. It consists of a layer of proteins packed between two layers of lipids.
Myelin is produced by specialized cells: oligodendrocytes in the central nervous system, and Schwann cells in the peripheral nervous system. Myelin sheaths wrap themselves around axons, the threadlike extensions of neurons that make up nerve fibers. Each oligodendrocyte can myelinate several axons.
Myelin can be destroyed by hereditary neurodegenerative disorders such as the leukodystrophies, and by acquired diseases such as multiple sclerosis.
Demyelinating diseases affect more than two million people worldwide.

>> Click HERE to read this complete article from THE MYELIN PROJECT

Multiple Sclerosis: Nature, Nurture, or Something Else?

April 9, 2008

Multiple sclerosis (MS) is a poorly understood disease that affects patients at an early age and, usually, lasts a lifetime. Factors that predispose to the development of MS include genetics, geographic location, sex and birth month, suggesting an interesting nature-nurture interaction in this disease process.

The increased rate of MS at high latitudes has been demonstrated in many studies, with those living in the Northern United States and Canada at a higher risk than those closer to the equator. This geographical influence is most commonly linked to the decreased (UV) radiation in these locations. UV light is a requirement for the production of vitamin D, and it is this effect that is most commonly thought to increase the risk of MS.

Read the article →

Wednesday, April 9, 2008

The follow-up OF (the) "My Hiatus" Story ..

The follow-up to My Hiatus - "I do for others as I would want them to do for me, Because I care"...

written April 9, 2008 - My MS Story Continues:

This message is a follow-up to my previous story.

I am writing this, because I care, to inform everybody of my actions, as foolish or thoughtless as they were at the time.

My actions, of stopping my medication, only hurt myself and I most definitely learned from it.
Never AGAIN, shall I underestimate what is wrong with me, or if my medication works.. I think this happened by reading too many other stories.

I have taken a great deal of heat from my family and friends for learning what they did, after the writing of My Hiatus.

Sure, there may be some of you: family, friends or medical personnel who felt betrayed, by my stupidity. But let's be real, I am human and I occasionally (- Yes I admit it - occasionally), make mistakes, blunders (or whatever other words you can think) of how I screwed-up.

It was my mistake and I will again state that I HAVE learned from my actions. I felt invincible and that nothing was going to hurt me. At the time, I even questioned if the medication was really doing anything for me. I know that MANY of you have often wondered the same thing.
I questioned as so many before me have also questioned: "How do we know that the medication is really working"? - Well NOW, I can say "it WAS REALLY working"!!
And it'll soon be working again...

My setback, has set me back (physically) maybe a few years and I can only hope that the time to bounce-back to the status of a few months ago, is a shorter road than the few year difference.

Many persons (after receiving my confession story -my hiatus) wrote directly to me. Some, left their comments on my new blog. In all, I heard back from well over 100 people. Most were surprised that "Stuart" would have gone off his medication. Why did he do this? After all, he preaches all the time of how important the medication is to slow the progression. What caused him to think?

Well here's my answer. It's firstly obvious that I wasn't thinking clearly when I opted to take a break. Was this, "my not thinking clearly", because of my MS? Maybe....Was my not thinking clearly, because of just too many other stresses of my life? Maybe... Who really knows?!

Never during my hiatus, did I stop preaching the same rhetoric of the medications as in the past.I guess you could say that I was only fooling and fibbing to myself.

As of this writing, I can say that I AM beginning to feel better. REST is what I am getting and I am sure that rest and medication is what is most needed at this time.

I wrote my previous story because I knew how important it was for me to continue to do, what I have done for all with MS.This being: "To PROVIDE MS Related knowledge". And in sending-out my hiatus story, it did provide you with knowledge.

It allowed you to know that the medications that we are to take to halt progression obviously does help (most of us).

Of course I would have to say "look how good I used to look and sound". I had energy and endurance, as long as I moderated my time. I had stamina (ahem) when needed. That was a result of doing the medication.

Notice that I never mentioned what medication it was, and now again is that I use, because the brand-name is not what's relevant. What is relevant is that You SHOULD never stop your medication unless your doctor and you (together) decide, the best course of action that you should be doing for your MS.

For the many who thought that I was having problems with my medication, I will tell you that there was no problem with it, just my error, in ceasing to use it.

After now having had a few injections once again (since I re-began my regimen), I am beginning to again Feel Empowered for a few hours here and there. Still overwhelmed though with fatigue which then relates to the cognitive problems, tingling and dizziness. What a horrible domino effect this has been causing...

Again- My Mission: "To EMPOWER You (the Patient, Caregiver, Family Member, Friend or Healthcare Professional), with current Info and Needed Knowledge of Multiple Sclerosis"
Why? Because, "Knowledge IS Power" and BECAUSE I CARE.. If I didn't care, I would not take the time to help others.

Be thankful that I Do Care. And so, I do for others, as I would want them to do for me!!

Now let's go forward and no longer backwards......

My Thanks again to all who left comments or called me or wrote to me in the past few days.


Stuart Schlossman
Thurs - April 10th - Addendum:
I did another injection last night ( I think this was number 6 or 7 - after the comeback), and I awoke today
almost feeling great. This, my friends - IS GOOD NEWS !!!!

Quality of Life often needs to begin with the Patient...

I wonder, if Julie (of About.com Multiple Sclerosis Guide) wrote these articles (found below) in response to my story of: April 04, '08: My Hiatus from my MS Medication - The Pros and Cons - a valuable lesson learned

Whether or not it derived after what I wrote, - I applaud her for this message:

from Julie Stachowiak, Ph.D.
I've been thinking quite a bit about quality of life for people with MS. I'm ready to fight for our rights, to demand equal access to places, to figure out how to make life better in general for us. Then it occurred to me - for some of us our quality of life is diminished by the very medications that we take to try and stay healthy. There are things we ourselves can do to make some of these things easier. I'm going to tackle dealing with side effects in the future, but I wanted to put out a couple of pieces on how to make injections less yucky. For some of us, injecting ourselves is a big deal, forcing us to confront phobias, for others, they are just plain unpleasant. I hope my little tips that I am bringing you will lessen the "yuck" factor and improve that little piece of your life. Take care of yourselves.

P.S. These tips will also help if you get infusions, or there is something else that you dread that you have to do regularly.

Continue to read this full article by clicking here: » Read More

The Last Interview - with Randy Pausch - an Inspiring lecture



with Randy Pausch

It is probably the last public speech Dr. Pausch will give anywhere. The 46-year-old computer science professor and father of three preschoolers has incurable pancreatic cancer. Doctors had given him (6) months to live.


Monday, April 7, 2008

Trichuris suis ova (TSO) Trial For Multiple Sclerosis

YahooBiz Press release

Asphelia Announces Initiation of An Independent TSO Trial for Multiple Sclerosis
Monday April 7, 8:00 am ET

MADISON, Wis., April 7, 2008 (PRIME NEWSWIRE) -- As announced in the March 7th issue of the Wisconsin State Journal, Dr. John Fleming, a leading neurologist at the UW Hospital, is initiating an investigator-initiated IND clinical trial to assess the safety and efficacy of Trichuris suis ova (TSO) in the treatment of Multiple Sclerosis (MS). Dr. Fleming's trial is funded by the Multiple Sclerosis Society, and is the first of its kind within the United States.

About TSO: ASP1002 is a helminth ova
(worm egg) technology currently being developed for the treatment of autoimmune diseases and immunological disorders, such as Crohn's Disease, Multiple Sclerosis, and asthma. More than 1,000 patients in Europe and the United States have taken TSO without significant side effects or safety issues.

» Read More

Sunday, April 6, 2008

Restless Legs Syndrome vs. MS

A Subscriber to the e-Newsletter is asking if anybody can let her know if they are effected with Restless Legs Syndrome (RLS) and how it might relate to MS?

Leave your comments here - Thank You

Re-Cycling the Push Stem of your Syringe?

Do you re-cycle the plastic items from your home?

Have you thought to re-cycle the plastic push stem of your injectable?

My question is: IS It safe to recycle the plunger portion of your syringe?

Medical syringes

A typical medical syringe with needle
A typical medical syringe with needle

Hypodermic syringes are used with hypodermic needles to inject liquid or gases into body tissues, or to remove from the body. Injecting of air into a blood vessel is undesirable, as it may cause an air embolism; preventing embolisms by removing air from the syringe is one of the reasons for the familiar image of holding a hypodermic syringe upside down, tapping it, and expelling a small amount of liquid before an injection into the bloodstream. However, the primary reason air bubbles are removed from the syringe prior to injection is to make sure an accurate dosage is delivered.

The barrel of a syringe is made of plastic or glass, and usually has graduated marks indicating the volume of fluid in the syringe, and is nearly always transparent. Glass syringes may be sterilized in an autoclave. However, most modern medical syringes are plastic with a rubber piston, because this type seals much better between the piston and the barrel and because they are cheap enough to dispose of after being used only once, reducing the risk of spreading blood-borne diseases. Re-use of needles and syringes has caused spread of diseases, especially HIV and Hepatitis among intravenous drug users. Syringes are commonly re-used by diabetics and this is safe, if the syringe is only used by one person.

Disposable medical syringes are sometimes used without a needle for orally administering liquid medicines to young children or animals because the dose can be measured accurately, and it is easier to squirt the medicine into the subject's mouth instead of coaxing the subject to drink out of a measuring spoon.

Please leave your comments .

Study aims to halt the progression of multiple sclerosis

Info obtained from : scamparoo.wordpress

New Wesley Research Institute study aims to halt the progression of multiple sclerosis

‘Might prove the most effective treatment of MS ever’ — research leader

A new research study being conducted at The Wesley Research Institute (WRI) aims to stop the progression of early active stage Multiple Sclerosis (MS) in its tracks.

There are currently more than 2.5 million people worldwide with MS, a chronic disease that affects the central nervous system.

They suffer from a range of debilitating symptoms including impaired gait and mobility, bladder and bowel dysfunction, cognitive and visual impairment, and profound muscle weakness.

Principal Investigator of the project at the WRI, Dr Pamela McCombe, is a neurologist at both The Wesley Hospital and Royal Brisbane and Women’s Hospital, and also Chairman of the WRI Research Committee.

“This study might prove to be the strongest, most effective treatment of MS ever.”

“Current treatments for MS only reduce the progression rate of the disease. This new treatment, if successful, will actually halt the progression of MS.”

“Not only does it aim to stop MS in its tracks but it will also spare MS sufferers from weekly injections replacing them with infusions over three consecutive days every year.”

“The medication targets lymphocytes (a type of white blood cell) to decrease the inflammatory reaction responsible for the progression of MS.”

Preliminary studies have demonstrated that as a result of this medication sufferers have experienced fewer disease relapses, a decrease in the formation of central nervous system lesions, and a reduction in cumulative disabilities.

“This suggests to me that there is every chance this medication will prove successful and become widely used.”

This is an international study involving 200 sites. The WRI is one of fifteen sites in Australia to trial this new treatment, and one of only two in Queensland. The other site is the Gold Coast Hospital.

The Multiple Sclerosis Society of Queensland said in a statement: “The Multiple Sclerosis Society of Queensland welcomes the participation of local researchers in ground breaking research that may one day provide freedom from MS for the thousands of Australians living with this disease, and endorses the quality of the contribution of Queensland research in this exciting world-wide effort.”


This MS study forms part of the WRI’s commitment to furthering neurological research, which also includes research into better treatment and diagnoses of brain tumours and stroke.

The WRI is currently recruiting volunteers for this study. For more information on please call the WRI’s Clinical Trials Centre on 07 3232 7920 or visit www.wesleyresearch.org.au. The research study is ethically approved and there are no costs associated with participation.

The Wesley Research Institute is an independent, not-for-profit medical research institute based in Brisbane that conducts research that that aims for immediate improvements to quality of life through better diagnosis, treatment and rehabilitation.

When We Don't Agree...Entirely...

The following was posted by Brain Cheese ( A huge MS Blogger) after I asked her ( and I guess, more than once), to post: My Hiatus Story

Read and decipher - (my own brain is not working clearly enough to understand what was written).

When We Don't Agree...Entirely...
I was diagnosed with Multiple Sclerosis on TAX DAY, April 15th, 2003 (Yes...your math is correct. My MS anniversary is just around the bend, so please send all cards and flowers NOW if you expect them to arrive on time! LOL). ...
Brain Cheese - http://brain-cheese.blogspot.com/