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Saturday, August 9, 2008

Study Participants Help Find New Treatments

Study Participants Help Find New Treatments

by Timothy L. Vollmer, M.D.

(NAPSI)-A new clinical trial called Bravo could offer an option to thousands of Americans living with multiple sclerosis (MS).

According to the National Multiple Sclerosis Society, approximately 400,000 Americans have MS, with 200 people being diagnosed every week.

» Read More

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An Incredible Magical Performance from Europe

Contributed by: Frank S of Connecticut

Click Here: Check out "YouTube - Magic Incredible Transformation.Grand Prize Winner Act."

If anybody else has anything entertaining to share with other readers, please send this to me.
Thank you

Thursday, August 7, 2008

Career Crossroads - Working With MS

The National MS Society and

MS LEARN ONLINE present...

Career Crossroads - Working With MS

This video webcast, the first of a two-part series, is entitled Career Crossroads - Working With MS.
Key topics include:
  • The emotional, social, and financial benefits of work
  • Impact of MS on employment
  • Impact of work on MS
Click here for the webcast, or copy into your browser:

If you have a pop-up blocker, you will need to disable it prior to participating in a MS Learn Online webcast.

Funding for this program was provided as an unrestricted educational grant from several National MS Society Chapters.
Email: mslearnonline@nmss.org

Multiple Sclerosis: IMPAX Reports Positive Results in Phase III Trial

Centre Daily Times 4:42 AM PDT

Thursday, Aug. 07, 2008
IMPAX Reports Positive Results in Phase III Trial with IPX056
-Provides Update on Brand Pharmaceutical Program- -Company Presenting Today at the Bank of America Specialty Pharmaceutical Conference-

HAYWARD, Calif. — IMPAX Laboratories, Inc. today announced that IPX056, an investigational extended-release formulation of baclofen, has met its clinical endpoints in a Phase III study of spasticity in multiple sclerosis patients. The Company also is providing an update on its brand pharmaceutical product program, which resides in its IMPAX Pharmaceuticals Division.

In a 173-patient, placebo and active comparator-controlled double blind Phase III study with a seven-week open label follow on, IPX056 was shown to be effective versus placebo in reducing spasticity in multiple sclerosis patients. IPX056 is an extended-release formulation of baclofen, the drug of choice in the treatment of spasticity, which has the potential to offer improved control of symptoms and dosing convenience.

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Modigene wins Israeli grant for multiple sclerosis research program

Pharmaceutical Business Review

6th August 2008
By Staff Writer

Modigene has reported that its Israeli-based R&D subsidiary has received approval for a special grant from the Israeli Office of the Chief Scientist in support of the company's development program for interferon-beta-CTP, its longer-acting version of interferon beta.

The Office of the Chief Scientist (OCS) has approved a special grant to support Modigene's interferon-beta-CTP (IFN-Beta-CTP) program for 2008-2009. The grant will provide cash reimbursements of 40% of expenses paid for IFN-Beta-CTP product development during this period.

» Read More

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His research did suggest how nerve cells lose their electrically insulating layers of myelin

Contributed by Matilde in Miami:


August 4, 2008

Professor J. Murdoch Ritchie: biophysicist and pharmacologist

The biophysicist and pharmacologist Murdoch Ritchie was a key figure in the development of neuropharmacology, the branch of medical science dealing with the action of drugs on and in the nervous system. He was best known for his substantial contributions to our understanding of the conduction of electrical impulses in peripheral nerves — particularly nerves in the face, arms, legs and torso.

In his studies of electrical conduction within nerve cells in the early 1970s, Ritchie used saxitoxin, a powerful poison derived from shellfish that kills by causing respiratory failure. It had been developed by the CIA for possible covert uses and stocks, in violation of a 1969 order by President Nixon, had not been destroyed. According to Ritchie, the CIA had kept enough saxitoxin to kill 5,000 people, and he obtained a quantity for his research.

Extremely small concentrations of the toxin block the conduction of electrical signals in nerves and can, therefore, be used to study the function of the nervous system.

Ritchie failed to discover a way of counteracting the effects of saxitoxin, his original goal, but his research did suggest how nerve cells lose their electrically insulating layers of myelin. This ultimately rendered the nervous system unable to conduct nerve impulses, leading to multiple sclerosis.

He also studied both the desirable and the hazardous effects of caffeine, publishing his conclusions in chapters in each of five editions of The Pharmacological Basis of Therapeutics, by Goodman & Gilman (1965-1985).

Joseph Murdoch Ritchie was born in Aberdeen in 1925. He studied mathematics and physics at Aberdeen University, graduating in 1944. He then took a post as a research physicist at the Telecommunications Research Establishment at Malvern, where he worked on the development of radar.

In 1946 he became a research student at University College London, in the world’s first department of biophysics, working on the dynamics of skeletal muscle contraction. He was awarded a BSc degree in physiology from UCL in 1949 and was appointed a junior lecturer. In 1951 he moved to the National Institute for Medical Research at Mill Hill, North London. He was awarded a PhD in biophysics in 1952 and a DSc in biophysics in 1960, both by UCL.

In 1956 he emigrated to the US and a post in the Department of Pharmacology at the Albert Einstein College of Medicine, Yeshiva University, New York. In 1963 he was appointed Professor of Pharmacology there.

In 1968 he moved to Yale as Professor of Pharmacology. He was director of Medical Studies at Yale for 30 years and served on many university committees. An energetic and meticulous experimentalist, he continued to conduct experiments until he retired in 2000. A prolific writer, he wrote and edited more than 70 reviews, chapters, books and monographs.

Ritchie was elected a Fellow of the Royal Society in 1976. He received many other honours and awards; he was a founding member of the Society for Neuroscience.

A charismatic person with a lively personality, Ritchie had a great zest for life. An enthusiastic skier, he regularly holidayed with his family in his beloved Zermatt, Switzerland.

His wife, a son and a daughter survive him.

Professor J. Murdoch Ritchie, biophysicist and pharmacologist, was born on June 10, 1925. He died on July 9, 2008, aged 83

Study Highlights Need For Early Learning Intervention In Some Children With MS

Article was Published May 15, 2008 by Medical News Today

Italian researchers compared cognitive function between 63 children with MS and 57 controls without MS, and found significant impairment in about one-third of the children with MS. The study results highlight the need for early interventions - such as accommodations that can be made in school - to address cognitive function in children with MS. Interventions of these types are among the comprehensive services offered at the National MS Society's network of Pediatric MS Centers of Excellence. Dr. M.P. Amato and colleagues (University of Florence, Italy) report their results in Neurology.

An estimated 8,000-10,000 children have multiple sclerosis in the United States, and another 10,000-15,000 experience disorders that may be related to MS. Cognitive changes are common in adults with MS, and although children with MS can experience difficulties remembering and concentrating, the extent of these problems is not known.

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Adult Stem Cells Reprogrammed To Become Myelin-Making Cells

Contributed by: Gerson G in South Florida

Medical News Today

Article Date: 01 Aug 2008 - 4:00 PDT

Research published in Nature Neuroscience , electronic publication ahead of print) has shown that adult stem cells in mice that are developing into nerve cells can be redirected to turn into myelin -making cells by changing a single gene . This type of research may some day help repair the damage to myelin which occurs in multiple sclerosis (MS).

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Wednesday, August 6, 2008

Research suggest brain cells may come back after damage from multiple sclerosis


Posted by Brie Zeltner August 05, 2008 15:43PM

Brain cells in areas targeted by multiple sclerosis may regenerate - often years after the initial injury, according to research by a team of Cleveland Clinic neuroscientists.

The finding, published online today, lends further support for the concept of adult neurogenesis -- that the human brain can regenerate itself, and in the case of MS, is working to repair itself.

Multiple sclerosis is a chronic disease in which the immune system begins to attack the fatty protective barrier around nerve fibers in the central nervous system. When that area, known as the myelin, is destroyed, the impulses traveling along those pathways from the brain or spinal cord can be slowed, distorted, or cut off completely if the nerve itself is injured.

The researchers examined the brains of nine multiple sclerosis patients who donated their organs after death in the hopes of furthering research on the disease,

"The brain is continuously trying to replace what has been destroyed -- not just myelin, but also neurons," said Bruce Trapp, one of the lead authors on the paper and chair of neurosciences at the Lerner Research Institute.

Trapp think the biggest impact of the paper will be just that -- that there is evidence of the neurogenesis in this area of the brain. Many scientists have resisted the increasing amount of evidence that shows regeneration of neurons in other areas of the brain, like the hippocampus, because of a long-held belief that the brain cannot regenerate. In short, you're stuck with what you've got.

"It's a controversial area, and it's something that's very difficult to prove," said Trapp.

Trapp and his team went looking for old MS lesions in the brains they examined, and wanted to know what happened to the neurons in those areas. They weren't surprised that many of them were destroyed, probably as "bystanders" when the myelin was attacked.

"But then we were shocked when we saw areas of old lesions, and these lesions can be decades old, that had very high concentrations of neurons," Trapp said. In one quarter of the lesions they looked at, there was a 72 percent increase in density of interneurons, which are the neurons that communicate locally.

The question of whether a motor neuron, which communicates over a long distance, could regenerate is still an unanswered question.

Trapp's team was able to count the neurons because the white matter is relatively neuron-poor compared to the rest of the brain. They were also able to show that the neurons had made connections to each other through synapses.

But, Trapp doesn't know if the neurons he saw were capable of communicating with one another or were functional.

Paris thanks ‘white-haired dude’ for McCain ad

TOTALLY - Having Nothing to do with MS , but still "in the News"


When MSNBC Screen Opens - click Launch on video monitor..

Funny and yet interesting to ponder

Tuesday, August 5, 2008

Earlier MS diagnosis may be possible


Earlier MS diagnosis may be possible

HEIDELBERG, Germany, Aug. 5 (UPI) -- German scientists say they've discovered a new magnetic resonance imaging medium that might enable the early diagnosis of multiple sclerosis.

Neuroradiologists and neurologists from University Hospitals of Heidelberg and Wurzburg said that in an animal model of multiple sclerosis, they have used a new contract medium -- Gadofluorine M -- to visualize inflammatory tissue damage, most of which had previously remained unrecognized.

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Monday, August 4, 2008

Clear MRI - Multiple Sclerosis???

A peer of ours, asked me the other day, if I ever heard of Clear MRI - Multiple Sclerosis?
Not understanding what she meant, I asked and she informed me that she has heard that there are people being diagnosed with MS, who show NO Lesions on their MR scans.

Being I am not a doctor, I told her that this is something that I can't answer, but I did mention that this is something I have never heard-of considering: Sclerosis means Scarring, which is also another word for lesion.

Does anybody have something or some wisdom to add to this ?

Please reply by leaving your comment