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Friday, January 23, 2009

New pill to treat Multiple Sclerosis may be available soon

New pill to treat Multiple Sclerosis may be available soon, says drugmaker Merck
Associated Press - Star Tribune
Last update: January 23, 2009

LONDON - German drugmaker Merck Serono is one step closer to releasing the first pill to treat multiple sclerosis, the company said Friday.

In a press statement, Merck said that patients taking cladribine tablets had a nearly 60 percent lower relapse rate than those on placebo pills. The two-year study included 1,326 MS patients who were randomly divided into three groups. Two groups received different doses of cladribine and one group received fake pills.

» Read More

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MS Learn Online

Topics discussed in this program include:
  • Building a team
  • The team begins at home
  • A self-mangement approach
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Thursday, January 22, 2009

Risk factors for multiple sclerosis

RISK FACTORS for Multiple Sclerosis

Doctors call things that make you more likely to get a disease risk factors. Having a risk factor for multiple sclerosis (MS) doesn't mean you'll get the disease. It just means you're more likely to get it than someone who doesn't have the risk factor. These are the main risk factors for MS.

Your family and your genes
You're more likely to get MS if other people in your family have it, especially a brother or sister. If you have a close relative with MS, you have about a 2 in 100 to 3 in 100 chance of getting it yourself.

There isn't any single gene that causes MS. Instead, some people probably get a mix of genes from their parents that increases their risk. This means you may be more likely to get MS if you have these genes. But other things also need to happen for you to get it.

Leaving Comments, Suggestions and/or Questions, are Always Appreciated. - Thank you

OPEN TOPIC - Medical Syringe - Waste

Many have asked this often question:
Where do I bring my Syringe Container when it is full?

and have asked other questions such as:

Am I allowed to place with my normal trash - for trash collection?
Can I bring to my doctor?
How much does it cost to Trash Medical Waste?

MY answer is usually -- I have no answer. To please ask your primary physician or your neurologist for their replies.

MAYBE Some of you, have a better answer(s)...

PLEASE reply by leaving a comment - THANK YOU


Wednesday, January 21, 2009

The Multiple Sclerosis Severity Score (MSSS) predicts disease severity over time

.J Neurol Sci. 2009 Jan 10. [Epub ahead of print] - Pubmed

Pachner AR, Steiner I.
Department of Neurology and Neurosciences, UMDNJ-New Jersey Medical School, Newark, NJ, USA.

BACKGROUND: The Multiple Sclerosis Severity Scale (MSSS) adds the element of disease duration to the expanded disease status score (EDSS) and is designed to provide a measure of disease severity. We have used this tool to address two questions: Can it be used to predict the accrual of disability over time in individual patients? Do the currently available therapies have an impact upon disease severity over time?

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The role of genes in the pathogenesis of MS


Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis

The role of genes in the pathogenesis of MS is complex. The authors found an association between a gene called Atg5 and MS, suggesting that it may contribute to inflammation in MS.

authors: Alirezaei M, Fox HS, Flynn CT, Moore CS, Hebb AL, Frausto RF, Bhan V, Kiosses WB, Whitton JL, Robertson GS, Crocker SJ

source: Autophagy. 2009 Feb 5;5(2).

Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, USA.

Multiple sclerosis (MS) is an inflammatory central nervous system (CNS) disorder characterized by T cell-mediated demyelination. In MS, prolonged T cell survival and increased T cell proliferation have been linked to disease relapse and progression.

Recently, the autophagy-related gene 5 (Atg5) has been shown to modulate T cell survival. In this study, we examined the expression of Atg5 using both a mouse model of autoimmune demyelination as well as blood and brain tissues from MS cases.

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Monday, January 19, 2009

Interferon Delivered via a Nasal Spray

Thursday January 15, 2009

There is potential good news coming for users of Avonex, Betaseron and Rebif. Those interferon treatments need to be injected and, let's just go ahead and say it, nobody likes injections.

Nerveda and Aegis Therapeutics announced that they have had successful preclinical results on a nasal spray to deliver the interferons.

The reason you simply can't have an pill for interferon treatment in multiple sclerosis is that this line of treatment relies on delicate protein molecules. Basically, protein molecules like to cling and bond to each other. If they do that too much, the immune system doens't react to them and produce the antibodies needed to reduce relaspe rates. A pill would be too unstable and too "bonded together" for it to be an effective interferon treatment.

A nasal spray would be a big deal. It's an effective (and much less painful) way to deliver interferon treatment. Expect to see clinical trails starting soon..

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Paly student researches potential cure for MS

Palo Alto Online

Uploaded: Thursday, January 15, 2009, 1:47 PM

Senior Hrishikesh Srinagesh earns award from Intel for research on therapeutic developments for multiple sclerosis

by Emilie Doolittle
Palo Alto Online Staff

When Palo Alto High School senior Hrishikesh Srinagesh volunteered at Lytton Gardens Senior Communities he worked with a woman named Alice who was talkative and "fun to be around." But every week he would come back to see her and she couldn't remember him.

"It was difficult for me," Srinagesh said. "It seemed unfathomable that plaque buildups, tangled neurons, and misfolded proteins could cause this kind of degeneration in her brain, turning my friend into a stranger with Alzheimer's disease."

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Trauma of teenage years tougher for those coping with multiple sclerosis

Provided by: Canadian Press
Written by: Shannon Montgomery, THE CANADIAN PRESS
Jan. 15, 2009

CALGARY - It started when Levi Barron's right hand curled into a claw shortly after his 13th birthday.

Always laid-back, he told his mom that he'd just learn to write with the other hand and not to worry.

But the debilitating stiffness crept to his other hand, and soon the athletic hockey player was having trouble walking and even fell a few times.

It took four doctors and a stint in hospital, paralyzed from the waist down and so dizzy he couldn't open his eyes without vomiting, for Levi to finally get a diagnosis of multiple sclerosis.

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