A web-blog (formerly known as Stu's Views and MS News), now published by MS Views and News, a patient advocacy organization. The information on this blog helps to Empower those affected by Multiple Sclerosis globally, with education, information, news and community resources.
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Multiple sclerosis (MS) is an inflammatory autoimmune disorder characterized by targeted destruction of myelin — a major component of the central nervous system — by self-reactive inflammatory T cells. Recent observations suggest an association between MS and inflammatory bowel disease (IBD), with increased incidence of Crohn’s disease (CD) and ulcerative colitis (UC), the two most common types of IBD, among MS patients. IBD is characterized by a chronic inflammation of the gastrointestinal tract, leading to disruption of the intestinal epithelial barrier, a phenomenon known as “leaky gut.” This loss of epithelial barrier function may allow luminal antigens to abnormally activate the host-immune response leading to a systemic autoimmune response. In the present study, the authors evaluated if Experimental Autoimmune Encephalomyelitis (EAE), a model for human MS in rodents, is accompanied by loss of mucosal immune homeostasis.