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Wednesday, October 1, 2014

What’s the Role of Myelin Oligodendrocyte Glycoprotein in NMO (NeuroMyelitis Optica)?

Researchers are working to refine a cell-based assay that more accurately identifies antibodies for myelin oligodendrocyte glycoprotein (MOG) in the serum of patients with neuromyelitis optica spectrum disorders. Some think that anti-MOG-positive patients may even represent a distinct demyelinating disease.

Scientists understand neuromyelitis optica spectrum disorders (NMOSD) far better now than when they were first described as Devic’s disease in 1894. NMOSD is an umbrella category including optic neuritis, myelitis, and acute disseminated encephalomyelitis (ADEM). While researchers understand NMOSD far better than they did even 10 years ago, so much remains obscured.

As we described in our four-part News Synthesis on NMO, researchers and clinicians believed NMO to be a subtype of multiple sclerosis until 2005, when researchers discovered a biomarker for the disease in an antibody that attacks a protein in astrocytes known as aquaporin-4. AQP4 is an integral membrane protein that helps conduct water through the cell membrane. According to Brian Weinshenker, M.D., of the Mayo Clinic in Minnesota, roughly 70% to 80% of adult NMOSD patients test positive for AQP4. Most of them are women.

Unfortunately, anti-AQP4-positive patients usually receive a dire prognosis. Relapses and disabilities are common, while recovery from the attacks tends to be incomplete. The body seems to attack the optic nerves and spinal cord, leading to problems in vision and walking.

MOG sits on the outer layer of the myelin sheath, making it an easy target for antibody attack. Credit: Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute.

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2 comments:

ANDERSON MORRISON said...





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ANDERSON MORRISON said...





My name is Lawrence, I am from U.K. I want to share my testimonies to the general public on how this great man called Dr Osas cure my sister from Genetic Herpes with the herbal medication gotten from dr. osas, he cures other diseases too herbal is a great medication. To hell with the government and their insane policy, he have a medication that is hundred percent assured to cure genital herpes and you don't need to spend so much money on anymore . I want you to contact dr Osas on: doctorosasherbalhome@gmail.com My family is now a brand new one, so stop your worries and go get your medication and set the family free of the deadly disease that hold no respect to family harmony. Thank you for reading my comment.

THESE ARE THE THINGS DR OSAS DOES
1. HERPES
2. LASSA FEVER
3. GONORRHEA
4. HIV/AIDS
5. LOW SPERM COUNT
6. MENOPAUSE DISEASE
7. EPILEPSY
8. ASEPSIS
9. CANCER
10. ANXIETY DEPRESSION
11. PREGNANCY PROBLEM
12. SHORT SIGHTEDNESS PROBLEM
14. Male menopause
15. Menopause - male
16. Menopause - peri
17. Menstruation problems
18. Mercury Poisoning
19. Migraine
20. Miscarriage
21. Mites (demodex mites)
22. Mites (scabies mites)
23. Motion sickness
24. Mouth ulcer
25. MRSA
26. Multiple sclerosis
27. Muscle cramps
28. Myodesopsia
29. Stroke
30. He can as well cast and remove spell