A web-blog (formerly known as Stu's Views and MS News), now published by MS Views and News, a patient advocacy organization. The information on this blog helps to Empower those affected by Multiple Sclerosis globally, with education, information, news and community resources.
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Monday, December 28, 2015
MS Patients Show Better Gait and Balance with Dalfampridine Treatment
Withdrawal/re-initiation study expands on known walking speed benefits of approved MS therapy
MS is a debilitating disease in which cells of the immune system attack the central nervous system (CNS), namely nerve fibers and myelin, the element that covers and protects nerve cells. The symptoms and severity of MS vary greatly from patient to patient, although functional limitations such as walking/gait dysfunction and balance impairment are fairly common. Walking difficulties arise from factors such as muscle weakness, spasticity (muscle tightness), balance problems, sensory deficits, and fatigue.
Dalfampridine in extended release (ER) form (Ampyra extended-release tablets; Acorda Therapeutics Inc.) has been shown to rehabilitate conduction in demyelinated nerves in animals. Data from two Phase 3 clinical trials showing that dalfampridine-ER was able to improve walking speed in MS patients was key to its being granted approval in the United States in 2010.