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Monday, February 8, 2016

Lemtrada Update

February 2016

RRMS Drug Works by Shifting Anti-Inflammatory Immune Profile, Study Shows Researchers have found that changes in the composition of immune molecules — specifically, a shift to more anti-inflammatory cytokines and regulatory T-cells (Tregs) — likely account for the efficiency of alemtuzumab (Lemtrada) as a treatment for relapsing-remitting multiple sclerosis (RRMS).

Researchers led by Stefania De Mercanti at the University of Turin, Italy, investigated the immune profiles of 29 MS patients enrolled in the CARE-MS I and II trials comparing the efficacy of alemtuzumab to Refib (interferon beta-1a). The patients were followed for 24 months, and blood samples were collected at six-month intervals, starting before treatment onset and ending after two years of treatment.
Scientists looked at the gene expression profile of 26 immune-related molecules, including cytokines, chemokines and their receptors, as well as transcription factors. Researchers also determined the relative amounts of T-helper cell types Th1 and Th17, as well as Tregs and the activity of a Treg suppressor, MBP.

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