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Friday, November 10, 2017
First Patient Enrolled in Mallinckrodt Phase 4 Trial of H.P. Acthar® Gel (Repository Corticotropin Injection) for Multiple Sclerosis Relapse
Pediatric and adult multiple sclerosis (MS) share many genetic variants suggesting similar biological processes are present, a recent study found. Major histocompatibility complex (MHC) variants beyond HLA–DRB1*15:01 and HLA–A*02 are also associated with pediatric-onset MS (POMS). Researchers comprehensively investigated the association between established MHC and non-MHC adult MS-associated variants and susceptibility to POMS. Cases with onset <18 years (n=569) and controls (n=16,251) were included. Adjusted logistic regression and meta-analyses were performed for individual risk variants and a weighted genetic risk score (wGRS) for non-MHC variants. Results were compared to adult MS cases (n= 7,588). They found:
Given the associations between smoking and comorbidities in individuals with multiple sclerosis (MS), health care providers should both (1) assess smoking history and quit attempts, and (2) encourage individuals with MS who smoke to become non-smokers and refer for treatment, as indicated, according to a recent study. In order to increase the chances that individuals will be successful in becoming non-smokers, clinicians would do well to also assess and treat depression in their patients who smoke and are also depressed. Researchers used a web-based survey to obtain cross-sectional data from 335 individuals with MS. They then examined the associations between smoking variables (current use, frequency, and quit attempts) and comorbidities, and found:
Wednesday, November 8, 2017
According to the National Multiple Sclerosis Society, around 65 percent of people living with the disease suffer from some cognitive issues — most notably, memory, concentration and speed of processing information.
If you find that you are frequently experiencing cognitive issues and that it’s affecting your daily life, you need to speak to your health care team. They’ll assess your problems and provide you with strategies to help you better deal with the situation.
By Andrea Rumbaugh - November 6, 2017
Erin Edenfield of TIRR Memorial Hermann demonstrates the Indego Exoskeletons Therapy kit with the help of Marcie Kern on Monday during the International Symposium on Wearable and Rehabilitation Robotics.
Vikki McFarland took 554 steps. Multiple sclerosis put her in a wheelchair in 2007, but with the wearable robotics she recently walked around the NeuroRecovery Research Center at TIRR Memorial Hermann, activating motors at her hips and knees by tilting her torso.
"I felt like there were new muscles in my body that I haven't felt in a long time," McFarland said.
There are a host of wearable devices being used by clinicians. One, for instance, puts participants on a treadmill while wearing a belt attached to wires. The wires put force on the pelvic in a manner needed for the patients to adjust their stance while walking and, ultimately, retrain their walking patterns.
National Survey Reveals Majority of Women Newly Diagnosed with Multiple Sclerosis Have Concerns They Aren’t Discussing with Their Healthcare Team
November 08, 2017 08:00 AM Eastern Standard Time
FRAZER, Pa. and AVON, Colo.--(BUSINESS WIRE)--Approximately 400,000 people in the U.S. have Multiple sclerosis (MS), an unpredictable disease of the central nervous system that affects 2-3 times as many women as men. Onset is usually between the ages of 20-40, a time when many women are building their careers, personal lives and families. Women newly diagnosed with MS have significant concerns about how these parts of their lives could change, but a survey asking about personal relationships, reproductive issues and employment concerns shows 98% felt many of these concerns were not addressed by their healthcare team when first diagnosed.
The survey was conducted by Wakefield Research for Teva Pharmaceuticals among 1,000 women diagnosed with MS in the last 5 years. It also showed that 71% of respondents believed talking to their doctor earlier or more openly would have made the first six months after diagnosis easier. To empower women to take charge of their MS, Teva and Can Do MS have developed tools to help women and healthcare professionals engage right from the start about topics that matter to women.
These resources can be found at mscando.org/womenandms.
The top reason women cited for not talking to a doctor or other healthcare professional about either their work, family planning or personal relationship concerns was that they aren’t comfortable talking about them. The new survey is an important examination of these areas and the concerns women face after diagnosis, including: ability to care for themselves (34%), ability to care for their current or future children (22%), career and work life demands (17%), ability to have children (15%) and personal relationships (13%).
Tuesday, November 7, 2017
Dr.B discusses sexual dysfunction in Multiple Sclerosis