The topographical model of #MS = By Stephen Krieger, MD --
The topographical model of #MS is my career contribution, and it’s changed the conversation towards a unified view of MS. This is the 10th anniversary 
of the initial idea, Oct 2013, that led to the paper tinyurl.com/yxk83byt & all that followed. A 
on how it came together.
of the initial idea, Oct 2013, that led to the paper tinyurl.com/yxk83byt & all that followed. A on how it came together.
I’m often asked how the idea for the topographical model of #MS came about, and the short answer is: from listening to my patients. In MS sometimes reserve is full, but when it’s drained MS reveals itself above the surface. High & low tide; the disease hiding below the threshold.
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Taking a closer look at the first sketch, Oct 3rd 2013:
The concept was already there – lesions, submerged by functional reserve. The tank, draining slowly, as brain atrophy occurs. Note the draining spigot in the lower left corner, an early detail later cut from the model.
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